Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease

The prevalence of nonalcoholic fatty liver disease (NAFLD) has been significantly increased due to the global epidemic of obesity. The disease progression from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) is closely linked to inflammation, insulin resistance, and dysbiosis. Althoug...

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Autores principales:	Rui Xue, Lianyong Su, Shengyi Lai, Yanyan Wang, Derrick Zhao, Jiangao Fan, Weidong Chen, Phillip B. Hylemon, Huiping Zhou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bile acids gut–liver axis bile acid receptor FXR TGR5 S1PR2 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d7694d2bc7f14f18a0a127caecc01430
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spelling	oai:doaj.org-article:d7694d2bc7f14f18a0a127caecc014302021-11-25T17:07:20ZBile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease10.3390/cells101128062073-4409https://doaj.org/article/d7694d2bc7f14f18a0a127caecc014302021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2806https://doaj.org/toc/2073-4409The prevalence of nonalcoholic fatty liver disease (NAFLD) has been significantly increased due to the global epidemic of obesity. The disease progression from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) is closely linked to inflammation, insulin resistance, and dysbiosis. Although extensive efforts have been aimed at elucidating the pathological mechanisms of NAFLD disease progression, current understanding remains incomplete, and no effective therapy is available. Bile acids (BAs) are not only important physiological detergents for the absorption of lipid-soluble nutrients in the intestine but also metabolic regulators. During the last two decades, BAs have been identified as important signaling molecules involved in lipid, glucose, and energy metabolism. Dysregulation of BA homeostasis has been associated with NAFLD disease severity. Identification of nuclear receptors and G-protein-coupled receptors activated by different BAs not only significantly expanded the current understanding of NAFLD/NASH disease progression but also provided the opportunity to develop potential therapeutics for NAFLD/NASH. In this review, we will summarize the recent studies with a focus on BA-mediated signaling pathways in NAFLD/NASH. Furthermore, the therapeutic implications of targeting BA-mediated signaling pathways for NAFLD will also be discussed.Rui XueLianyong SuShengyi LaiYanyan WangDerrick ZhaoJiangao FanWeidong ChenPhillip B. HylemonHuiping ZhouMDPI AGarticlebile acidsgut–liver axisbile acid receptorFXRTGR5S1PR2Biology (General)QH301-705.5ENCells, Vol 10, Iss 2806, p 2806 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bile acids gut–liver axis bile acid receptor FXR TGR5 S1PR2 Biology (General) QH301-705.5
spellingShingle	bile acids gut–liver axis bile acid receptor FXR TGR5 S1PR2 Biology (General) QH301-705.5 Rui Xue Lianyong Su Shengyi Lai Yanyan Wang Derrick Zhao Jiangao Fan Weidong Chen Phillip B. Hylemon Huiping Zhou Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease
description	The prevalence of nonalcoholic fatty liver disease (NAFLD) has been significantly increased due to the global epidemic of obesity. The disease progression from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) is closely linked to inflammation, insulin resistance, and dysbiosis. Although extensive efforts have been aimed at elucidating the pathological mechanisms of NAFLD disease progression, current understanding remains incomplete, and no effective therapy is available. Bile acids (BAs) are not only important physiological detergents for the absorption of lipid-soluble nutrients in the intestine but also metabolic regulators. During the last two decades, BAs have been identified as important signaling molecules involved in lipid, glucose, and energy metabolism. Dysregulation of BA homeostasis has been associated with NAFLD disease severity. Identification of nuclear receptors and G-protein-coupled receptors activated by different BAs not only significantly expanded the current understanding of NAFLD/NASH disease progression but also provided the opportunity to develop potential therapeutics for NAFLD/NASH. In this review, we will summarize the recent studies with a focus on BA-mediated signaling pathways in NAFLD/NASH. Furthermore, the therapeutic implications of targeting BA-mediated signaling pathways for NAFLD will also be discussed.
format	article
author	Rui Xue Lianyong Su Shengyi Lai Yanyan Wang Derrick Zhao Jiangao Fan Weidong Chen Phillip B. Hylemon Huiping Zhou
author_facet	Rui Xue Lianyong Su Shengyi Lai Yanyan Wang Derrick Zhao Jiangao Fan Weidong Chen Phillip B. Hylemon Huiping Zhou
author_sort	Rui Xue
title	Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease
title_short	Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease
title_full	Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease
title_fullStr	Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease
title_full_unstemmed	Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease
title_sort	bile acid receptors and the gut–liver axis in nonalcoholic fatty liver disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d7694d2bc7f14f18a0a127caecc01430
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Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease

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