Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review

Navid Rabiee,1 Sepideh Ahmadi,2,3 Zeynab Arab,1 Mojtaba Bagherzadeh,1 Moein Safarkhani,1 Behzad Nasseri,4,5 Mohammad Rabiee,6 Mohammadreza Tahriri,7 Thomas J Webster,8 Lobat Tayebi7 1Department of Chemistry, Sharif University of Technology, Tehran, Iran; 2Student Research Committee, Department of Me...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rabiee N, Ahmadi S, Arab Z, Bagherzadeh M, Safarkhani M, Nasseri B, Rabiee M, Tahriri M, Webster TJ, Tayebi L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	aptamer polyethyleneimine hybrid nanocomplexes antibiotic targeting gene delivery systems Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d7700548a7234935b96c92fae228ea9b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d7700548a7234935b96c92fae228ea9b
record_format	dspace
spelling	oai:doaj.org-article:d7700548a7234935b96c92fae228ea9b2021-12-02T08:29:01ZAptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review1178-2013https://doaj.org/article/d7700548a7234935b96c92fae228ea9b2020-06-01T00:00:00Zhttps://www.dovepress.com/aptamer-hybrid-nanocomplexes-as-targeting-components-for-antibioticgen-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Navid Rabiee,1 Sepideh Ahmadi,2,3 Zeynab Arab,1 Mojtaba Bagherzadeh,1 Moein Safarkhani,1 Behzad Nasseri,4,5 Mohammad Rabiee,6 Mohammadreza Tahriri,7 Thomas J Webster,8 Lobat Tayebi7 1Department of Chemistry, Sharif University of Technology, Tehran, Iran; 2Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Chemical Engineering Department and Bioengineering Division, Hacettepe University, Beytepe, Ankara 06800, Turkey; 5Chemical Engineering and Applied Chemistry Department, Atilim University, Ankara, Turkey; 6Biomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran; 7Marquette University School of Dentistry, Milwaukee, WI 53233, USA; 8Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USACorrespondence: Thomas J Webster; Mohammadreza Tahriri Email th.webster@neu.edu; Mohammadreza.tahriri@marquette.eduAbstract: With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting approach for cancer treatment in the decades ahead to meet our growing societal needs.Keywords: aptamer, polyethyleneimine, hybrid nanocomplexes, antibiotic, targeting, gene delivery systemsRabiee NAhmadi SArab ZBagherzadeh MSafarkhani MNasseri BRabiee MTahriri MWebster TJTayebi LDove Medical Pressarticleaptamerpolyethyleneiminehybrid nanocomplexesantibiotictargetinggene delivery systemsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 4237-4256 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	aptamer polyethyleneimine hybrid nanocomplexes antibiotic targeting gene delivery systems Medicine (General) R5-920
spellingShingle	aptamer polyethyleneimine hybrid nanocomplexes antibiotic targeting gene delivery systems Medicine (General) R5-920 Rabiee N Ahmadi S Arab Z Bagherzadeh M Safarkhani M Nasseri B Rabiee M Tahriri M Webster TJ Tayebi L Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review
description	Navid Rabiee,1 Sepideh Ahmadi,2,3 Zeynab Arab,1 Mojtaba Bagherzadeh,1 Moein Safarkhani,1 Behzad Nasseri,4,5 Mohammad Rabiee,6 Mohammadreza Tahriri,7 Thomas J Webster,8 Lobat Tayebi7 1Department of Chemistry, Sharif University of Technology, Tehran, Iran; 2Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Chemical Engineering Department and Bioengineering Division, Hacettepe University, Beytepe, Ankara 06800, Turkey; 5Chemical Engineering and Applied Chemistry Department, Atilim University, Ankara, Turkey; 6Biomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran; 7Marquette University School of Dentistry, Milwaukee, WI 53233, USA; 8Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USACorrespondence: Thomas J Webster; Mohammadreza Tahriri Email th.webster@neu.edu; Mohammadreza.tahriri@marquette.eduAbstract: With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting approach for cancer treatment in the decades ahead to meet our growing societal needs.Keywords: aptamer, polyethyleneimine, hybrid nanocomplexes, antibiotic, targeting, gene delivery systems
format	article
author	Rabiee N Ahmadi S Arab Z Bagherzadeh M Safarkhani M Nasseri B Rabiee M Tahriri M Webster TJ Tayebi L
author_facet	Rabiee N Ahmadi S Arab Z Bagherzadeh M Safarkhani M Nasseri B Rabiee M Tahriri M Webster TJ Tayebi L
author_sort	Rabiee N
title	Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review
title_short	Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review
title_full	Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review
title_fullStr	Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review
title_full_unstemmed	Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review
title_sort	aptamer hybrid nanocomplexes as targeting components for antibiotic/gene delivery systems and diagnostics: a review
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d7700548a7234935b96c92fae228ea9b
work_keys_str_mv	AT rabieen aptamerhybridnanocomplexesastargetingcomponentsforantibioticgenedeliverysystemsanddiagnosticsareview AT ahmadis aptamerhybridnanocomplexesastargetingcomponentsforantibioticgenedeliverysystemsanddiagnosticsareview AT arabz aptamerhybridnanocomplexesastargetingcomponentsforantibioticgenedeliverysystemsanddiagnosticsareview AT bagherzadehm aptamerhybridnanocomplexesastargetingcomponentsforantibioticgenedeliverysystemsanddiagnosticsareview AT safarkhanim aptamerhybridnanocomplexesastargetingcomponentsforantibioticgenedeliverysystemsanddiagnosticsareview AT nasserib aptamerhybridnanocomplexesastargetingcomponentsforantibioticgenedeliverysystemsanddiagnosticsareview AT rabieem aptamerhybridnanocomplexesastargetingcomponentsforantibioticgenedeliverysystemsanddiagnosticsareview AT tahririm aptamerhybridnanocomplexesastargetingcomponentsforantibioticgenedeliverysystemsanddiagnosticsareview AT webstertj aptamerhybridnanocomplexesastargetingcomponentsforantibioticgenedeliverysystemsanddiagnosticsareview AT tayebil aptamerhybridnanocomplexesastargetingcomponentsforantibioticgenedeliverysystemsanddiagnosticsareview
_version_	1718398512183377920

Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review

Ejemplares similares