Plant-Derived Compounds as Promising Therapeutics for Vitiligo

Vitiligo is the most common depigmenting disorder characterized by white patches in the skin. The pathogenetic origin of vitiligo revolves around autoimmune destruction of melanocytes in which, for instance, oxidative stress is responsible for melanocyte molecular, organelle dysfunction and melanocy...

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Autores principales:	Yaobin Pang, Shi Wu, Yingjie He, Qing Nian, Jing Lei, Yejing Yao, Jing Guo, Jinhao Zeng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	vitiligo oxidative stress natural product melanocytes flavonoids phenols Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d770aa773fa24da88918548663328ea7
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spelling	oai:doaj.org-article:d770aa773fa24da88918548663328ea72021-11-11T06:16:58ZPlant-Derived Compounds as Promising Therapeutics for Vitiligo1663-981210.3389/fphar.2021.685116https://doaj.org/article/d770aa773fa24da88918548663328ea72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.685116/fullhttps://doaj.org/toc/1663-9812Vitiligo is the most common depigmenting disorder characterized by white patches in the skin. The pathogenetic origin of vitiligo revolves around autoimmune destruction of melanocytes in which, for instance, oxidative stress is responsible for melanocyte molecular, organelle dysfunction and melanocyte specific antigen exposure as well as melanocyte cell death and thus serves as an important contributor for vitiligo progression. In recent years, natural products have shown a wide range of pharmacological bioactivities against many skin diseases, and this review focuses on the effects and mechanisms of natural compounds against vitiligo models. It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/β-catenin signaling pathways were reported to be implicated in these protective effects. This review discusses the great potential of plant derived natural products as anti-vitiligo agents, as well as the future directions to explore.Yaobin PangShi WuYingjie HeQing NianJing LeiYejing YaoJing GuoJinhao ZengJinhao ZengFrontiers Media S.A.articlevitiligooxidative stressnatural productmelanocytesflavonoidsphenolsTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitiligo oxidative stress natural product melanocytes flavonoids phenols Therapeutics. Pharmacology RM1-950
spellingShingle	vitiligo oxidative stress natural product melanocytes flavonoids phenols Therapeutics. Pharmacology RM1-950 Yaobin Pang Shi Wu Yingjie He Qing Nian Jing Lei Yejing Yao Jing Guo Jinhao Zeng Jinhao Zeng Plant-Derived Compounds as Promising Therapeutics for Vitiligo
description	Vitiligo is the most common depigmenting disorder characterized by white patches in the skin. The pathogenetic origin of vitiligo revolves around autoimmune destruction of melanocytes in which, for instance, oxidative stress is responsible for melanocyte molecular, organelle dysfunction and melanocyte specific antigen exposure as well as melanocyte cell death and thus serves as an important contributor for vitiligo progression. In recent years, natural products have shown a wide range of pharmacological bioactivities against many skin diseases, and this review focuses on the effects and mechanisms of natural compounds against vitiligo models. It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/β-catenin signaling pathways were reported to be implicated in these protective effects. This review discusses the great potential of plant derived natural products as anti-vitiligo agents, as well as the future directions to explore.
format	article
author	Yaobin Pang Shi Wu Yingjie He Qing Nian Jing Lei Yejing Yao Jing Guo Jinhao Zeng Jinhao Zeng
author_facet	Yaobin Pang Shi Wu Yingjie He Qing Nian Jing Lei Yejing Yao Jing Guo Jinhao Zeng Jinhao Zeng
author_sort	Yaobin Pang
title	Plant-Derived Compounds as Promising Therapeutics for Vitiligo
title_short	Plant-Derived Compounds as Promising Therapeutics for Vitiligo
title_full	Plant-Derived Compounds as Promising Therapeutics for Vitiligo
title_fullStr	Plant-Derived Compounds as Promising Therapeutics for Vitiligo
title_full_unstemmed	Plant-Derived Compounds as Promising Therapeutics for Vitiligo
title_sort	plant-derived compounds as promising therapeutics for vitiligo
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d770aa773fa24da88918548663328ea7
work_keys_str_mv	AT yaobinpang plantderivedcompoundsaspromisingtherapeuticsforvitiligo AT shiwu plantderivedcompoundsaspromisingtherapeuticsforvitiligo AT yingjiehe plantderivedcompoundsaspromisingtherapeuticsforvitiligo AT qingnian plantderivedcompoundsaspromisingtherapeuticsforvitiligo AT jinglei plantderivedcompoundsaspromisingtherapeuticsforvitiligo AT yejingyao plantderivedcompoundsaspromisingtherapeuticsforvitiligo AT jingguo plantderivedcompoundsaspromisingtherapeuticsforvitiligo AT jinhaozeng plantderivedcompoundsaspromisingtherapeuticsforvitiligo AT jinhaozeng plantderivedcompoundsaspromisingtherapeuticsforvitiligo
_version_	1718439543398465536

Plant-Derived Compounds as Promising Therapeutics for Vitiligo

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