Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study.

Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used Mendelian randomization (MR) to explore causal relationships between the degree of alcohol consumption...

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Autores principales:	Joanna Lankester, Daniela Zanetti, Erik Ingelsson, Themistocles L Assimes
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d7710c000f8c4f35b56b108eeacf0421
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spelling	oai:doaj.org-article:d7710c000f8c4f35b56b108eeacf04212021-12-02T20:18:25ZAlcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study.1932-620310.1371/journal.pone.0255801https://doaj.org/article/d7710c000f8c4f35b56b108eeacf04212021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255801https://doaj.org/toc/1932-6203Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used Mendelian randomization (MR) to explore causal relationships between the degree of alcohol consumption and several cardiometabolic traits in the UK Biobank. Using the well-established ADH1B Arg47His variant (rs1229984) and up to 24 additional SNPs recently found to be associated with alcohol consumption in an independent dataset as instruments, we conducted two-stage least squares and inverse weighted variance MR analyses, both as one-sample analyses in the UK Biobank and as two-sample analyses in external consortia. In the UK Biobank inverse variance weighted analyses, we found that one additional drink of alcohol per day was positively associated with systolic blood pressure (beta = 2.65 mmHg [1.40, 3.89]), hemorrhagic stroke (OR = 2.25 [1.41, 3.60]), and atrial fibrillation (OR = 1.26 [1.07, 1.48]), which were replicated in multivariable analyses. Alcohol was also associated with all cardiovascular disease and all-cause death. A positive association with myocardial infarction did not replicate in multivariable analysis, with suggestive mediation through blood pressure; similarly, a positive association between alcohol use with type 2 diabetes was mitigated by BMI in multivariable analysis. Findings were generally null in replication with two-sample analyses. Alcohol was not protective for any disease outcome with any analysis method, dataset, or strata. Stratifications by sex and smoking in the UK Biobank revealed higher point estimates of risk for several outcomes for men and mixed results for smoking strata, but no statistically significant heterogeneity. Our results are consistent with an overall harmful and/or null effect of alcohol on cardiometabolic health at all levels of use and suggest that even moderate alcohol use should not be promoted as a part of a healthy diet and lifestyle.Joanna LankesterDaniela ZanettiErik IngelssonThemistocles L AssimesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255801 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joanna Lankester Daniela Zanetti Erik Ingelsson Themistocles L Assimes Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study.
description	Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used Mendelian randomization (MR) to explore causal relationships between the degree of alcohol consumption and several cardiometabolic traits in the UK Biobank. Using the well-established ADH1B Arg47His variant (rs1229984) and up to 24 additional SNPs recently found to be associated with alcohol consumption in an independent dataset as instruments, we conducted two-stage least squares and inverse weighted variance MR analyses, both as one-sample analyses in the UK Biobank and as two-sample analyses in external consortia. In the UK Biobank inverse variance weighted analyses, we found that one additional drink of alcohol per day was positively associated with systolic blood pressure (beta = 2.65 mmHg [1.40, 3.89]), hemorrhagic stroke (OR = 2.25 [1.41, 3.60]), and atrial fibrillation (OR = 1.26 [1.07, 1.48]), which were replicated in multivariable analyses. Alcohol was also associated with all cardiovascular disease and all-cause death. A positive association with myocardial infarction did not replicate in multivariable analysis, with suggestive mediation through blood pressure; similarly, a positive association between alcohol use with type 2 diabetes was mitigated by BMI in multivariable analysis. Findings were generally null in replication with two-sample analyses. Alcohol was not protective for any disease outcome with any analysis method, dataset, or strata. Stratifications by sex and smoking in the UK Biobank revealed higher point estimates of risk for several outcomes for men and mixed results for smoking strata, but no statistically significant heterogeneity. Our results are consistent with an overall harmful and/or null effect of alcohol on cardiometabolic health at all levels of use and suggest that even moderate alcohol use should not be promoted as a part of a healthy diet and lifestyle.
format	article
author	Joanna Lankester Daniela Zanetti Erik Ingelsson Themistocles L Assimes
author_facet	Joanna Lankester Daniela Zanetti Erik Ingelsson Themistocles L Assimes
author_sort	Joanna Lankester
title	Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study.
title_short	Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study.
title_full	Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study.
title_fullStr	Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study.
title_full_unstemmed	Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study.
title_sort	alcohol use and cardiometabolic risk in the uk biobank: a mendelian randomization study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d7710c000f8c4f35b56b108eeacf0421
work_keys_str_mv	AT joannalankester alcoholuseandcardiometabolicriskintheukbiobankamendelianrandomizationstudy AT danielazanetti alcoholuseandcardiometabolicriskintheukbiobankamendelianrandomizationstudy AT erikingelsson alcoholuseandcardiometabolicriskintheukbiobankamendelianrandomizationstudy AT themistocleslassimes alcoholuseandcardiometabolicriskintheukbiobankamendelianrandomizationstudy
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Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study.

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