Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway
Abstract Long scan times prohibit a widespread clinical applicability of 4D flow MRI in Fontan patients. As pulsatility in the Fontan pathway is minimal during the cardiac cycle, acquiring non-ECG gated 3D flow MRI may result in a reduction of scan time while accurately obtaining time-averaged clini...
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Nature Portfolio
2021
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oai:doaj.org-article:d771dfc6e4e64ce9a23cb137b410796d2021-12-02T11:45:03ZReduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway10.1038/s41598-021-85936-62045-2322https://doaj.org/article/d771dfc6e4e64ce9a23cb137b410796d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85936-6https://doaj.org/toc/2045-2322Abstract Long scan times prohibit a widespread clinical applicability of 4D flow MRI in Fontan patients. As pulsatility in the Fontan pathway is minimal during the cardiac cycle, acquiring non-ECG gated 3D flow MRI may result in a reduction of scan time while accurately obtaining time-averaged clinical parameters in comparison with 2D and 4D flow MRI. Thirty-two Fontan patients prospectively underwent 2D (reference), 3D and 4D flow MRI of the Fontan pathway. Multiple clinical parameters were assessed from time-averaged flow rates, including the right-to-left pulmonary flow distribution (main endpoint) and systemic-to-pulmonary collateral flow (SPCF). A ten-fold reduction in scan time was achieved [4D flow 15.9 min (SD 2.7 min) and 3D flow 1.6 min (SD 7.8 s), p < 0.001] with a superior signal-to-noise ratio [mean ratio of SNRs 1.7 (0.8), p < 0.001] and vessel sharpness [mean ratio 1.2 (0.4), p = 0.01] with 3D flow. Compared to 2D flow, good–excellent agreement was shown for mean flow rates (ICC 0.82–0.96) and right-to-left pulmonary flow distribution (ICC 0.97). SPCF derived from 3D flow showed good agreement with that from 4D flow (ICC 0.86). 3D flow MRI allows for obtaining time-averaged flow rates and derived clinical parameters in the Fontan pathway with good–excellent agreement with 2D and 4D flow, but with a tenfold reduction in scan time and significantly improved image quality compared to 4D flow.Friso M. RijnbergHans C. van AssenJoe F. JuffermansLucia J. M. KroftPieter J. van den BoogaardPatrick J. H. de KoningMark G. HazekampSéline F. S. van der WoudeEvangeline G. WarmerdamTim LeinerHeynric B. GrotenhuisJelle J. GoemanHildo J. LambArno A. W. RoestJos J. M. WestenbergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Friso M. Rijnberg Hans C. van Assen Joe F. Juffermans Lucia J. M. Kroft Pieter J. van den Boogaard Patrick J. H. de Koning Mark G. Hazekamp Séline F. S. van der Woude Evangeline G. Warmerdam Tim Leiner Heynric B. Grotenhuis Jelle J. Goeman Hildo J. Lamb Arno A. W. Roest Jos J. M. Westenberg Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway |
| description |
Abstract Long scan times prohibit a widespread clinical applicability of 4D flow MRI in Fontan patients. As pulsatility in the Fontan pathway is minimal during the cardiac cycle, acquiring non-ECG gated 3D flow MRI may result in a reduction of scan time while accurately obtaining time-averaged clinical parameters in comparison with 2D and 4D flow MRI. Thirty-two Fontan patients prospectively underwent 2D (reference), 3D and 4D flow MRI of the Fontan pathway. Multiple clinical parameters were assessed from time-averaged flow rates, including the right-to-left pulmonary flow distribution (main endpoint) and systemic-to-pulmonary collateral flow (SPCF). A ten-fold reduction in scan time was achieved [4D flow 15.9 min (SD 2.7 min) and 3D flow 1.6 min (SD 7.8 s), p < 0.001] with a superior signal-to-noise ratio [mean ratio of SNRs 1.7 (0.8), p < 0.001] and vessel sharpness [mean ratio 1.2 (0.4), p = 0.01] with 3D flow. Compared to 2D flow, good–excellent agreement was shown for mean flow rates (ICC 0.82–0.96) and right-to-left pulmonary flow distribution (ICC 0.97). SPCF derived from 3D flow showed good agreement with that from 4D flow (ICC 0.86). 3D flow MRI allows for obtaining time-averaged flow rates and derived clinical parameters in the Fontan pathway with good–excellent agreement with 2D and 4D flow, but with a tenfold reduction in scan time and significantly improved image quality compared to 4D flow. |
| format |
article |
| author |
Friso M. Rijnberg Hans C. van Assen Joe F. Juffermans Lucia J. M. Kroft Pieter J. van den Boogaard Patrick J. H. de Koning Mark G. Hazekamp Séline F. S. van der Woude Evangeline G. Warmerdam Tim Leiner Heynric B. Grotenhuis Jelle J. Goeman Hildo J. Lamb Arno A. W. Roest Jos J. M. Westenberg |
| author_facet |
Friso M. Rijnberg Hans C. van Assen Joe F. Juffermans Lucia J. M. Kroft Pieter J. van den Boogaard Patrick J. H. de Koning Mark G. Hazekamp Séline F. S. van der Woude Evangeline G. Warmerdam Tim Leiner Heynric B. Grotenhuis Jelle J. Goeman Hildo J. Lamb Arno A. W. Roest Jos J. M. Westenberg |
| author_sort |
Friso M. Rijnberg |
| title |
Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway |
| title_short |
Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway |
| title_full |
Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway |
| title_fullStr |
Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway |
| title_full_unstemmed |
Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway |
| title_sort |
reduced scan time and superior image quality with 3d flow mri compared to 4d flow mri for hemodynamic evaluation of the fontan pathway |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d771dfc6e4e64ce9a23cb137b410796d |
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