Viral organization of human proteins.

Although maps of intracellular interactions are increasingly well characterized, little is known about large-scale maps of host-pathogen protein interactions. The investigation of host-pathogen interactions can reveal features of pathogenesis and provide a foundation for the development of drugs and...

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Autores principales:	Stefan Wuchty, Geoffrey Siwo, Michael T Ferdig
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d77371b9050c43ce8e4c35aa3389f340
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spelling	oai:doaj.org-article:d77371b9050c43ce8e4c35aa3389f3402021-11-18T06:35:42ZViral organization of human proteins.1932-620310.1371/journal.pone.0011796https://doaj.org/article/d77371b9050c43ce8e4c35aa3389f3402010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20827298/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Although maps of intracellular interactions are increasingly well characterized, little is known about large-scale maps of host-pathogen protein interactions. The investigation of host-pathogen interactions can reveal features of pathogenesis and provide a foundation for the development of drugs and disease prevention strategies. A compilation of experimentally verified interactions between HIV-1 and human proteins and a set of HIV-dependency factors (HDF) allowed insights into the topology and intricate interplay between viral and host proteins on a large scale. We found that targeted and HDF proteins appear predominantly in rich-clubs, groups of human proteins that are strongly intertwined among each other. These assemblies of proteins may serve as an infection gateway, allowing the virus to take control of the human host by reaching protein pathways and diversified cellular functions in a pronounced and focused way. Particular transcription factors and protein kinases facilitate indirect interactions between HDFs and viral proteins. Discerning the entanglement of directly targeted and indirectly interacting proteins may uncover molecular and functional sites that can provide novel perspectives on the progression of HIV infection and highlight new avenues to fight this virus.Stefan WuchtyGeoffrey SiwoMichael T FerdigPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 8, p e11796 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefan Wuchty Geoffrey Siwo Michael T Ferdig Viral organization of human proteins.
description	Although maps of intracellular interactions are increasingly well characterized, little is known about large-scale maps of host-pathogen protein interactions. The investigation of host-pathogen interactions can reveal features of pathogenesis and provide a foundation for the development of drugs and disease prevention strategies. A compilation of experimentally verified interactions between HIV-1 and human proteins and a set of HIV-dependency factors (HDF) allowed insights into the topology and intricate interplay between viral and host proteins on a large scale. We found that targeted and HDF proteins appear predominantly in rich-clubs, groups of human proteins that are strongly intertwined among each other. These assemblies of proteins may serve as an infection gateway, allowing the virus to take control of the human host by reaching protein pathways and diversified cellular functions in a pronounced and focused way. Particular transcription factors and protein kinases facilitate indirect interactions between HDFs and viral proteins. Discerning the entanglement of directly targeted and indirectly interacting proteins may uncover molecular and functional sites that can provide novel perspectives on the progression of HIV infection and highlight new avenues to fight this virus.
format	article
author	Stefan Wuchty Geoffrey Siwo Michael T Ferdig
author_facet	Stefan Wuchty Geoffrey Siwo Michael T Ferdig
author_sort	Stefan Wuchty
title	Viral organization of human proteins.
title_short	Viral organization of human proteins.
title_full	Viral organization of human proteins.
title_fullStr	Viral organization of human proteins.
title_full_unstemmed	Viral organization of human proteins.
title_sort	viral organization of human proteins.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/d77371b9050c43ce8e4c35aa3389f340
work_keys_str_mv	AT stefanwuchty viralorganizationofhumanproteins AT geoffreysiwo viralorganizationofhumanproteins AT michaeltferdig viralorganizationofhumanproteins
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Viral organization of human proteins.

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