Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin

Kinesin-13s are microtubule depolymerizing enzymes. Here the authors present the crystal structure of a DARPin fused construct comprising the short neck region and motor domain of kinesin-13 in complex with an αβ-tubulin heterodimer, which shows that kinesin-13 functions by stabilizing a curved tubu...

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Autores principales:	Weiyi Wang, Soraya Cantos-Fernandes, Yuncong Lv, Hureshitanmu Kuerban, Shoeb Ahmad, Chunguang Wang, Benoît Gigant
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d77b0f1dd0244051951a29439456c549
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spelling	oai:doaj.org-article:d77b0f1dd0244051951a29439456c5492021-12-02T13:24:33ZInsight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin10.1038/s41467-017-00091-92041-1723https://doaj.org/article/d77b0f1dd0244051951a29439456c5492017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00091-9https://doaj.org/toc/2041-1723Kinesin-13s are microtubule depolymerizing enzymes. Here the authors present the crystal structure of a DARPin fused construct comprising the short neck region and motor domain of kinesin-13 in complex with an αβ-tubulin heterodimer, which shows that kinesin-13 functions by stabilizing a curved tubulin conformation.Weiyi WangSoraya Cantos-FernandesYuncong LvHureshitanmu KuerbanShoeb AhmadChunguang WangBenoît GigantNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weiyi Wang Soraya Cantos-Fernandes Yuncong Lv Hureshitanmu Kuerban Shoeb Ahmad Chunguang Wang Benoît Gigant Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin
description	Kinesin-13s are microtubule depolymerizing enzymes. Here the authors present the crystal structure of a DARPin fused construct comprising the short neck region and motor domain of kinesin-13 in complex with an αβ-tubulin heterodimer, which shows that kinesin-13 functions by stabilizing a curved tubulin conformation.
format	article
author	Weiyi Wang Soraya Cantos-Fernandes Yuncong Lv Hureshitanmu Kuerban Shoeb Ahmad Chunguang Wang Benoît Gigant
author_facet	Weiyi Wang Soraya Cantos-Fernandes Yuncong Lv Hureshitanmu Kuerban Shoeb Ahmad Chunguang Wang Benoît Gigant
author_sort	Weiyi Wang
title	Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin
title_short	Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin
title_full	Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin
title_fullStr	Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin
title_full_unstemmed	Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin
title_sort	insight into microtubule disassembly by kinesin-13s from the structure of kif2c bound to tubulin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d77b0f1dd0244051951a29439456c549
work_keys_str_mv	AT weiyiwang insightintomicrotubuledisassemblybykinesin13sfromthestructureofkif2cboundtotubulin AT sorayacantosfernandes insightintomicrotubuledisassemblybykinesin13sfromthestructureofkif2cboundtotubulin AT yunconglv insightintomicrotubuledisassemblybykinesin13sfromthestructureofkif2cboundtotubulin AT hureshitanmukuerban insightintomicrotubuledisassemblybykinesin13sfromthestructureofkif2cboundtotubulin AT shoebahmad insightintomicrotubuledisassemblybykinesin13sfromthestructureofkif2cboundtotubulin AT chunguangwang insightintomicrotubuledisassemblybykinesin13sfromthestructureofkif2cboundtotubulin AT benoitgigant insightintomicrotubuledisassemblybykinesin13sfromthestructureofkif2cboundtotubulin
_version_	1718393123505176576

Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin

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