Fractal analysis of 11C-methionine PET in patients with newly diagnosed glioma

Abstract Background The present study tested the possible utility of fractal analysis from l-[methyl-11C]-methionine (MET) uptake in patients with newly diagnosed gliomas for differentiating glioma, especially in relation to isocitrate dehydrogenase 1 (IDH1) mutation status, and as compared with the...

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Autores principales:	Yukito Maeda, Yuka Yamamoto, Takashi Norikane, Katsuya Mitamura, Tetsuhiro Hatakeyama, Keisuke Miyake, Yoshihiro Nishiyama, Nobuyuki Kudomi
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Fractal analysis Glioma PET 11C-methionine Grading IDH1 Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/d77bae9279d6487b8749cf3d6497090e
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spelling	oai:doaj.org-article:d77bae9279d6487b8749cf3d6497090e2021-11-08T10:57:42ZFractal analysis of 11C-methionine PET in patients with newly diagnosed glioma10.1186/s40658-021-00418-y2197-7364https://doaj.org/article/d77bae9279d6487b8749cf3d6497090e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40658-021-00418-yhttps://doaj.org/toc/2197-7364Abstract Background The present study tested the possible utility of fractal analysis from l-[methyl-11C]-methionine (MET) uptake in patients with newly diagnosed gliomas for differentiating glioma, especially in relation to isocitrate dehydrogenase 1 (IDH1) mutation status, and as compared with the conventional standardized uptake value (SUV) parameters. Methods Investigations of MET PET/CT were performed retrospectively in 47 patients with newly diagnosed glioma. Tumors were divided into three groups: lower grade glioma (IDH1-mutant diffuse astrocytoma and IDH1-mutant anaplastic astrocytoma), higher grade glioma (IDH1-wildtype diffuse astrocytoma and IDH1-wildtype anaplastic astrocytoma), and glioblastoma. The fractal dimension for tumor, maximum SUV (SUVmax) for tumor (T) and mean SUV for normal contralateral hemisphere (N) were calculated, and the tumor-to-normal (T/N) ratio was determined. Metabolic tumor volume (MTV) and total lesion MET uptake (TLMU) were also measured. Results There were significant differences in SUVmax (p = 0.006) and T/N ratio (p = 0.02) between lower grade glioma and glioblastoma. There were no significant differences among any of the three groups in MTV or TLMU. Significant differences were obtained in the fractal dimension between lower grade glioma and higher grade glioma (p = 0.006) and glioblastoma (p < 0.001). Conclusions The results of this preliminary study in a small patient population suggest that the fractal dimension using MET PET in patients with newly diagnosed gliomas is useful for differentiating glioma, especially in relation to IDH1 mutation status, which has not been possible with SUV parameters.Yukito MaedaYuka YamamotoTakashi NorikaneKatsuya MitamuraTetsuhiro HatakeyamaKeisuke MiyakeYoshihiro NishiyamaNobuyuki KudomiSpringerOpenarticleFractal analysisGliomaPET11C-methionineGradingIDH1Medical physics. Medical radiology. Nuclear medicineR895-920ENEJNMMI Physics, Vol 8, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fractal analysis Glioma PET 11C-methionine Grading IDH1 Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	Fractal analysis Glioma PET 11C-methionine Grading IDH1 Medical physics. Medical radiology. Nuclear medicine R895-920 Yukito Maeda Yuka Yamamoto Takashi Norikane Katsuya Mitamura Tetsuhiro Hatakeyama Keisuke Miyake Yoshihiro Nishiyama Nobuyuki Kudomi Fractal analysis of 11C-methionine PET in patients with newly diagnosed glioma
description	Abstract Background The present study tested the possible utility of fractal analysis from l-[methyl-11C]-methionine (MET) uptake in patients with newly diagnosed gliomas for differentiating glioma, especially in relation to isocitrate dehydrogenase 1 (IDH1) mutation status, and as compared with the conventional standardized uptake value (SUV) parameters. Methods Investigations of MET PET/CT were performed retrospectively in 47 patients with newly diagnosed glioma. Tumors were divided into three groups: lower grade glioma (IDH1-mutant diffuse astrocytoma and IDH1-mutant anaplastic astrocytoma), higher grade glioma (IDH1-wildtype diffuse astrocytoma and IDH1-wildtype anaplastic astrocytoma), and glioblastoma. The fractal dimension for tumor, maximum SUV (SUVmax) for tumor (T) and mean SUV for normal contralateral hemisphere (N) were calculated, and the tumor-to-normal (T/N) ratio was determined. Metabolic tumor volume (MTV) and total lesion MET uptake (TLMU) were also measured. Results There were significant differences in SUVmax (p = 0.006) and T/N ratio (p = 0.02) between lower grade glioma and glioblastoma. There were no significant differences among any of the three groups in MTV or TLMU. Significant differences were obtained in the fractal dimension between lower grade glioma and higher grade glioma (p = 0.006) and glioblastoma (p < 0.001). Conclusions The results of this preliminary study in a small patient population suggest that the fractal dimension using MET PET in patients with newly diagnosed gliomas is useful for differentiating glioma, especially in relation to IDH1 mutation status, which has not been possible with SUV parameters.
format	article
author	Yukito Maeda Yuka Yamamoto Takashi Norikane Katsuya Mitamura Tetsuhiro Hatakeyama Keisuke Miyake Yoshihiro Nishiyama Nobuyuki Kudomi
author_facet	Yukito Maeda Yuka Yamamoto Takashi Norikane Katsuya Mitamura Tetsuhiro Hatakeyama Keisuke Miyake Yoshihiro Nishiyama Nobuyuki Kudomi
author_sort	Yukito Maeda
title	Fractal analysis of 11C-methionine PET in patients with newly diagnosed glioma
title_short	Fractal analysis of 11C-methionine PET in patients with newly diagnosed glioma
title_full	Fractal analysis of 11C-methionine PET in patients with newly diagnosed glioma
title_fullStr	Fractal analysis of 11C-methionine PET in patients with newly diagnosed glioma
title_full_unstemmed	Fractal analysis of 11C-methionine PET in patients with newly diagnosed glioma
title_sort	fractal analysis of 11c-methionine pet in patients with newly diagnosed glioma
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/d77bae9279d6487b8749cf3d6497090e
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Fractal analysis of 11C-methionine PET in patients with newly diagnosed glioma

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