Prevalence of Orofacial Clefts and Associated Factors in Infants

BACKGROUND AND OBJECTIVE: Orofacial clefts are the most common congenital facial defect. Genetic and environmental factors play a role in their development. The prevalence of orofacial clefts in Qom province has not been studied so far. The aim of this study was to evaluate the prevalence of orofaci...

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Autores principales:	S Khosroshahian, A Mehdipoor, M Aghaali, F Salehi, H Rahimi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2021
Materias:	cleft lip cleft palate infant congenital malformation. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d77bbbe87b6a498385c27a7f7b19e2cb
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spelling	oai:doaj.org-article:d77bbbe87b6a498385c27a7f7b19e2cb2021-11-29T07:40:50ZPrevalence of Orofacial Clefts and Associated Factors in Infants1561-41072251-7170https://doaj.org/article/d77bbbe87b6a498385c27a7f7b19e2cb2021-03-01T00:00:00Zhttp://jbums.org/article-1-9760-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Orofacial clefts are the most common congenital facial defect. Genetic and environmental factors play a role in their development. The prevalence of orofacial clefts in Qom province has not been studied so far. The aim of this study was to evaluate the prevalence of orofacial clefts and associated factors in infants born in Qom province during 2010-2018. METHODS: In this cross-sectional study, during nine years, the medical files of all infants with orofacial clefts and the files of their mothers in all hospitals of Qom province were examined. The files of 476 healthy infants were also evaluated to investigate the associated factors. Healthy infants were selected one number before and one after the case number of sick infants. Infant-related variables (weight, blood type, and other illnesses) and parent-related factors (age, smoking, alcohol, and medications, illness, consanguineous marriage, and number of children) were extracted through reviewing the files or telephone interview. FINDINGS: Of the 171,270 infants, 238 were found with orofacial clefts (1.39 per 1,000 births). Isolated cleft palate with 39.5% was the most common type of anomaly. Among the studied factors, the percentage of smoking in fathers in the case group (34.5%) was higher than the control group (24.2%) (p=0.004). Moreover, the history of maternal high blood pressure in the case group (7.6%) was higher than the control group (3.4%) (p=0.013). The incidence of diabetes in mothers of the case group (18.9%) was higher than the control group (8.2%) (p=0.001). CONCLUSION: The results of the study showed that the prevalence of orofacial cleft is 1.39 per 1000 births and smoking, diabetes and high blood pressure are the associated risk factors.S KhosroshahianA MehdipoorM AghaaliF SalehiH RahimiBabol University of Medical Sciencesarticlecleft lipcleft palateinfantcongenital malformation.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 23, Iss 1, Pp 421-428 (2021)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	cleft lip cleft palate infant congenital malformation. Medicine R Medicine (General) R5-920
spellingShingle	cleft lip cleft palate infant congenital malformation. Medicine R Medicine (General) R5-920 S Khosroshahian A Mehdipoor M Aghaali F Salehi H Rahimi Prevalence of Orofacial Clefts and Associated Factors in Infants
description	BACKGROUND AND OBJECTIVE: Orofacial clefts are the most common congenital facial defect. Genetic and environmental factors play a role in their development. The prevalence of orofacial clefts in Qom province has not been studied so far. The aim of this study was to evaluate the prevalence of orofacial clefts and associated factors in infants born in Qom province during 2010-2018. METHODS: In this cross-sectional study, during nine years, the medical files of all infants with orofacial clefts and the files of their mothers in all hospitals of Qom province were examined. The files of 476 healthy infants were also evaluated to investigate the associated factors. Healthy infants were selected one number before and one after the case number of sick infants. Infant-related variables (weight, blood type, and other illnesses) and parent-related factors (age, smoking, alcohol, and medications, illness, consanguineous marriage, and number of children) were extracted through reviewing the files or telephone interview. FINDINGS: Of the 171,270 infants, 238 were found with orofacial clefts (1.39 per 1,000 births). Isolated cleft palate with 39.5% was the most common type of anomaly. Among the studied factors, the percentage of smoking in fathers in the case group (34.5%) was higher than the control group (24.2%) (p=0.004). Moreover, the history of maternal high blood pressure in the case group (7.6%) was higher than the control group (3.4%) (p=0.013). The incidence of diabetes in mothers of the case group (18.9%) was higher than the control group (8.2%) (p=0.001). CONCLUSION: The results of the study showed that the prevalence of orofacial cleft is 1.39 per 1000 births and smoking, diabetes and high blood pressure are the associated risk factors.
format	article
author	S Khosroshahian A Mehdipoor M Aghaali F Salehi H Rahimi
author_facet	S Khosroshahian A Mehdipoor M Aghaali F Salehi H Rahimi
author_sort	S Khosroshahian
title	Prevalence of Orofacial Clefts and Associated Factors in Infants
title_short	Prevalence of Orofacial Clefts and Associated Factors in Infants
title_full	Prevalence of Orofacial Clefts and Associated Factors in Infants
title_fullStr	Prevalence of Orofacial Clefts and Associated Factors in Infants
title_full_unstemmed	Prevalence of Orofacial Clefts and Associated Factors in Infants
title_sort	prevalence of orofacial clefts and associated factors in infants
publisher	Babol University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/d77bbbe87b6a498385c27a7f7b19e2cb
work_keys_str_mv	AT skhosroshahian prevalenceoforofacialcleftsandassociatedfactorsininfants AT amehdipoor prevalenceoforofacialcleftsandassociatedfactorsininfants AT maghaali prevalenceoforofacialcleftsandassociatedfactorsininfants AT fsalehi prevalenceoforofacialcleftsandassociatedfactorsininfants AT hrahimi prevalenceoforofacialcleftsandassociatedfactorsininfants
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Prevalence of Orofacial Clefts and Associated Factors in Infants

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