Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis

Nanopore sequencing (ONT) has been used in SARS-CoV-2 studies, however adoption of ONT for SARS-CoV-2 surveillance has been limited due to common concerns around sequencing accuracy. Here, the authors perform a comprehensive evaluation of ONT analytical performance on 157 matched SARS-CoV-2-positive...

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Autores principales:	Rowena A. Bull, Thiruni N. Adikari, James M. Ferguson, Jillian M. Hammond, Igor Stevanovski, Alicia G. Beukers, Zin Naing, Malinna Yeang, Andrey Verich, Hasindu Gamaarachchi, Ki Wook Kim, Fabio Luciani, Sacha Stelzer-Braid, John-Sebastian Eden, William D. Rawlinson, Sebastiaan J. van Hal, Ira W. Deveson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d77df009f76046bb9bfe8be6833f8152
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spelling	oai:doaj.org-article:d77df009f76046bb9bfe8be6833f81522021-12-02T10:48:00ZAnalytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis10.1038/s41467-020-20075-62041-1723https://doaj.org/article/d77df009f76046bb9bfe8be6833f81522020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20075-6https://doaj.org/toc/2041-1723Nanopore sequencing (ONT) has been used in SARS-CoV-2 studies, however adoption of ONT for SARS-CoV-2 surveillance has been limited due to common concerns around sequencing accuracy. Here, the authors perform a comprehensive evaluation of ONT analytical performance on 157 matched SARS-CoV-2-positive patient specimens and synthetic RNA controls.Rowena A. BullThiruni N. AdikariJames M. FergusonJillian M. HammondIgor StevanovskiAlicia G. BeukersZin NaingMalinna YeangAndrey VerichHasindu GamaarachchiKi Wook KimFabio LucianiSacha Stelzer-BraidJohn-Sebastian EdenWilliam D. RawlinsonSebastiaan J. van HalIra W. DevesonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rowena A. Bull Thiruni N. Adikari James M. Ferguson Jillian M. Hammond Igor Stevanovski Alicia G. Beukers Zin Naing Malinna Yeang Andrey Verich Hasindu Gamaarachchi Ki Wook Kim Fabio Luciani Sacha Stelzer-Braid John-Sebastian Eden William D. Rawlinson Sebastiaan J. van Hal Ira W. Deveson Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis
description	Nanopore sequencing (ONT) has been used in SARS-CoV-2 studies, however adoption of ONT for SARS-CoV-2 surveillance has been limited due to common concerns around sequencing accuracy. Here, the authors perform a comprehensive evaluation of ONT analytical performance on 157 matched SARS-CoV-2-positive patient specimens and synthetic RNA controls.
format	article
author	Rowena A. Bull Thiruni N. Adikari James M. Ferguson Jillian M. Hammond Igor Stevanovski Alicia G. Beukers Zin Naing Malinna Yeang Andrey Verich Hasindu Gamaarachchi Ki Wook Kim Fabio Luciani Sacha Stelzer-Braid John-Sebastian Eden William D. Rawlinson Sebastiaan J. van Hal Ira W. Deveson
author_facet	Rowena A. Bull Thiruni N. Adikari James M. Ferguson Jillian M. Hammond Igor Stevanovski Alicia G. Beukers Zin Naing Malinna Yeang Andrey Verich Hasindu Gamaarachchi Ki Wook Kim Fabio Luciani Sacha Stelzer-Braid John-Sebastian Eden William D. Rawlinson Sebastiaan J. van Hal Ira W. Deveson
author_sort	Rowena A. Bull
title	Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis
title_short	Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis
title_full	Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis
title_fullStr	Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis
title_full_unstemmed	Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis
title_sort	analytical validity of nanopore sequencing for rapid sars-cov-2 genome analysis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d77df009f76046bb9bfe8be6833f8152
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Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis

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