Cancer stem cell gene profile as predictor of relapse in high risk stage II and stage III, radically resected colon cancer patients.

Clinical data indicate that prognostic stratification of radically resected colorectal cancer based on disease stage only may not be always be adequate. Preclinical findings suggest that cancer stem cells may influence the biological behaviour of colorectal cancer independently from stage: objective...

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Autores principales:	Riccardo Giampieri, Mario Scartozzi, Cristian Loretelli, Francesco Piva, Alessandra Mandolesi, Giovanni Lezoche, Michela Del Prete, Alessandro Bittoni, Luca Faloppi, Maristella Bianconi, Luca Cecchini, Mario Guerrieri, Italo Bearzi, Stefano Cascinu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d77f787decfb4d558ac2bee5360ddb17
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spelling	oai:doaj.org-article:d77f787decfb4d558ac2bee5360ddb172021-11-18T08:57:00ZCancer stem cell gene profile as predictor of relapse in high risk stage II and stage III, radically resected colon cancer patients.1932-620310.1371/journal.pone.0072843https://doaj.org/article/d77f787decfb4d558ac2bee5360ddb172013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023782/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Clinical data indicate that prognostic stratification of radically resected colorectal cancer based on disease stage only may not be always be adequate. Preclinical findings suggest that cancer stem cells may influence the biological behaviour of colorectal cancer independently from stage: objective of the study was to assess whether a panel of stemness markers were correlated with clinical outcome in resected stage II and III colon cancer patients. A panel of 66 markers of stemness were analysed and thus patients were divided into two groups (A and B) with most patients clustering in a manner consistent with different time to relapse by using a statistical algorithm. A total of 62 patients were analysed. Thirty-six (58%) relapsed during the follow-up period (range 1.63-86.5 months). Twelve (19%) and 50 (81%) patients were allocated into group A and B, respectively. A significantly different median relapse-free survival was observed between the 2 groups (22.18 vs 42.85 months, p=0.0296). Among of all genes tested, those with the higher "weight" in determining different prognosis were CD44, ALCAM, DTX2, HSPA9, CCNA2, PDX1, MYST1, COL1A1 and ABCG2. This analysis supports the idea that, other than stage, biological variables, such as expression levels of colon cancer stem cell genes, may be relevant in determining an increased risk of relapse in resected colorectal cancer patients.Riccardo GiampieriMario ScartozziCristian LoretelliFrancesco PivaAlessandra MandolesiGiovanni LezocheMichela Del PreteAlessandro BittoniLuca FaloppiMaristella BianconiLuca CecchiniMario GuerrieriItalo BearziStefano CascinuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e72843 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Riccardo Giampieri Mario Scartozzi Cristian Loretelli Francesco Piva Alessandra Mandolesi Giovanni Lezoche Michela Del Prete Alessandro Bittoni Luca Faloppi Maristella Bianconi Luca Cecchini Mario Guerrieri Italo Bearzi Stefano Cascinu Cancer stem cell gene profile as predictor of relapse in high risk stage II and stage III, radically resected colon cancer patients.
description	Clinical data indicate that prognostic stratification of radically resected colorectal cancer based on disease stage only may not be always be adequate. Preclinical findings suggest that cancer stem cells may influence the biological behaviour of colorectal cancer independently from stage: objective of the study was to assess whether a panel of stemness markers were correlated with clinical outcome in resected stage II and III colon cancer patients. A panel of 66 markers of stemness were analysed and thus patients were divided into two groups (A and B) with most patients clustering in a manner consistent with different time to relapse by using a statistical algorithm. A total of 62 patients were analysed. Thirty-six (58%) relapsed during the follow-up period (range 1.63-86.5 months). Twelve (19%) and 50 (81%) patients were allocated into group A and B, respectively. A significantly different median relapse-free survival was observed between the 2 groups (22.18 vs 42.85 months, p=0.0296). Among of all genes tested, those with the higher "weight" in determining different prognosis were CD44, ALCAM, DTX2, HSPA9, CCNA2, PDX1, MYST1, COL1A1 and ABCG2. This analysis supports the idea that, other than stage, biological variables, such as expression levels of colon cancer stem cell genes, may be relevant in determining an increased risk of relapse in resected colorectal cancer patients.
format	article
author	Riccardo Giampieri Mario Scartozzi Cristian Loretelli Francesco Piva Alessandra Mandolesi Giovanni Lezoche Michela Del Prete Alessandro Bittoni Luca Faloppi Maristella Bianconi Luca Cecchini Mario Guerrieri Italo Bearzi Stefano Cascinu
author_facet	Riccardo Giampieri Mario Scartozzi Cristian Loretelli Francesco Piva Alessandra Mandolesi Giovanni Lezoche Michela Del Prete Alessandro Bittoni Luca Faloppi Maristella Bianconi Luca Cecchini Mario Guerrieri Italo Bearzi Stefano Cascinu
author_sort	Riccardo Giampieri
title	Cancer stem cell gene profile as predictor of relapse in high risk stage II and stage III, radically resected colon cancer patients.
title_short	Cancer stem cell gene profile as predictor of relapse in high risk stage II and stage III, radically resected colon cancer patients.
title_full	Cancer stem cell gene profile as predictor of relapse in high risk stage II and stage III, radically resected colon cancer patients.
title_fullStr	Cancer stem cell gene profile as predictor of relapse in high risk stage II and stage III, radically resected colon cancer patients.
title_full_unstemmed	Cancer stem cell gene profile as predictor of relapse in high risk stage II and stage III, radically resected colon cancer patients.
title_sort	cancer stem cell gene profile as predictor of relapse in high risk stage ii and stage iii, radically resected colon cancer patients.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d77f787decfb4d558ac2bee5360ddb17
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Cancer stem cell gene profile as predictor of relapse in high risk stage II and stage III, radically resected colon cancer patients.

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