High-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring

Gang Feng,1 Lan Hao,1 Chunyan Xu,1 Haitao Ran,1 Yuanyi Zheng,1 Pan Li,1 Yang Cao,1 Qi Wang,2 Jizhu Xia,1 Zhigang Wang1 1Department of Ultrasound, Institute of Ultrasound Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging...

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Autores principales:	Feng G, Hao L, Xu C, Ran H, Zheng Y, Li P, Cao Y, Wang Q, Xia J, Wang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	HIFU nanoscale bubble-generating liposomes efficiency synergize Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d78244fc014b412c8faad3b3eb43b7ee
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spelling	oai:doaj.org-article:d78244fc014b412c8faad3b3eb43b7ee2021-12-02T02:28:07ZHigh-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring1178-2013https://doaj.org/article/d78244fc014b412c8faad3b3eb43b7ee2017-06-01T00:00:00Zhttps://www.dovepress.com/high-intensity-focused-ultrasound-triggered-nanoscale-bubble-generatin-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Gang Feng,1 Lan Hao,1 Chunyan Xu,1 Haitao Ran,1 Yuanyi Zheng,1 Pan Li,1 Yang Cao,1 Qi Wang,2 Jizhu Xia,1 Zhigang Wang1 1Department of Ultrasound, Institute of Ultrasound Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging, 2State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Chongqing, People’s Republic of China Abstract: High-intensity focused ultrasound (HIFU) is widely applied to tumors in clinical practice due to its minimally invasive approach. However, several issues lower therapeutic efficiency in some cases. Many synergists such as microbubbles and perfluorocarbon nanoparticles have recently been used to improve HIFU treatment efficiency, but none were determined to be effective and safe in vivo. In this study, nanoscale bubble-generating liposomes (liposomes containing ammonium bicarbonate [Lip-ABC]) were prepared by film hydration followed by sequential extrusion. Their stable nanoscale particle diameter was confirmed, and their bubble-generating capacity after HIFU triggering was demonstrated with ultrasound imaging. Lip-ABC had good stability in vivo and accumulated in the tumor interstitial space based on the enhanced permeability and retention effect evaluated by photoacoustic imaging. When used to synergize HIFU ablation to bovine liver in vitro and implanted breast tumors of BALB/c nude mice, Lip-ABC outperformed the control. Importantly, all mice survived HIFU treatment, suggesting that Lip-ABC is a safe HIFU synergist. Keywords: HIFU, nanoscale bubble-generating liposomes, efficiency, synergizeFeng GHao LXu CRan HZheng YLi PCao YWang QXia JWang ZDove Medical PressarticleHIFUnanoscale bubble-generating liposomesefficiencysynergizeMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4647-4659 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIFU nanoscale bubble-generating liposomes efficiency synergize Medicine (General) R5-920
spellingShingle	HIFU nanoscale bubble-generating liposomes efficiency synergize Medicine (General) R5-920 Feng G Hao L Xu C Ran H Zheng Y Li P Cao Y Wang Q Xia J Wang Z High-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring
description	Gang Feng,1 Lan Hao,1 Chunyan Xu,1 Haitao Ran,1 Yuanyi Zheng,1 Pan Li,1 Yang Cao,1 Qi Wang,2 Jizhu Xia,1 Zhigang Wang1 1Department of Ultrasound, Institute of Ultrasound Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging, 2State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology, Chongqing, People’s Republic of China Abstract: High-intensity focused ultrasound (HIFU) is widely applied to tumors in clinical practice due to its minimally invasive approach. However, several issues lower therapeutic efficiency in some cases. Many synergists such as microbubbles and perfluorocarbon nanoparticles have recently been used to improve HIFU treatment efficiency, but none were determined to be effective and safe in vivo. In this study, nanoscale bubble-generating liposomes (liposomes containing ammonium bicarbonate [Lip-ABC]) were prepared by film hydration followed by sequential extrusion. Their stable nanoscale particle diameter was confirmed, and their bubble-generating capacity after HIFU triggering was demonstrated with ultrasound imaging. Lip-ABC had good stability in vivo and accumulated in the tumor interstitial space based on the enhanced permeability and retention effect evaluated by photoacoustic imaging. When used to synergize HIFU ablation to bovine liver in vitro and implanted breast tumors of BALB/c nude mice, Lip-ABC outperformed the control. Importantly, all mice survived HIFU treatment, suggesting that Lip-ABC is a safe HIFU synergist. Keywords: HIFU, nanoscale bubble-generating liposomes, efficiency, synergize
format	article
author	Feng G Hao L Xu C Ran H Zheng Y Li P Cao Y Wang Q Xia J Wang Z
author_facet	Feng G Hao L Xu C Ran H Zheng Y Li P Cao Y Wang Q Xia J Wang Z
author_sort	Feng G
title	High-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring
title_short	High-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring
title_full	High-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring
title_fullStr	High-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring
title_full_unstemmed	High-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring
title_sort	high-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/d78244fc014b412c8faad3b3eb43b7ee
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High-intensity focused ultrasound-triggered nanoscale bubble-generating liposomes for efficient and safe tumor ablation under photoacoustic imaging monitoring

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