Management of chronic pain in the elderly: focus on transdermal buprenorphine

Nalini Vadivelu, Roberta L HinesDepartment of Anesthesiology, Yale University School of Medicine, New Haven, USAAbstract: Chronic pain in the elderly is a significant problem. Pharmacokinetic and metabolic changes associated with increased age makes the elderly vulnerable to side effects and overdos...

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Autores principales:	Nalini Vadivelu, Roberta L Hines
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/d78673b555b34c6eb9fd9b4957f7ecea
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spelling	oai:doaj.org-article:d78673b555b34c6eb9fd9b4957f7ecea2021-12-02T02:34:41ZManagement of chronic pain in the elderly: focus on transdermal buprenorphine1178-1998https://doaj.org/article/d78673b555b34c6eb9fd9b4957f7ecea2008-09-01T00:00:00Zhttps://www.dovepress.com/management-of-chronic-pain-in-the-elderly-focus-on-transdermal-bupreno-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Nalini Vadivelu, Roberta L HinesDepartment of Anesthesiology, Yale University School of Medicine, New Haven, USAAbstract: Chronic pain in the elderly is a significant problem. Pharmacokinetic and metabolic changes associated with increased age makes the elderly vulnerable to side effects and overdosing associated with analgesic agents. Therefore the management of chronic cancer pain and chronic nonmalignant pain in this growing population is an ongoing challenge. New routes of administration have opened up new treatment options to meet this challenge. The transdermal buprenorphine matrix allows for slow release of buprenorphine and damage does not produce dose dumping. In addition the long-acting analgesic property and relative safety profile makes it a suitable choice for the treatment of chronic pain in the elderly. Its safe use in the presence of renal failure makes it an attractive choice for older individuals. Recent scientific studies have shown no evidence of a ceiling dose of analgesia in man but only a ceiling effect for respiratory depression, increasing its safety profile. It appears that transdermal buprenorphine can be used in clinical practice safely and efficaciously for treating chronic pain in the elderly.Keywords: transdermal buprenorphine, chronic pain, elderlyNalini VadiveluRoberta L HinesDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 421-430 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Nalini Vadivelu Roberta L Hines Management of chronic pain in the elderly: focus on transdermal buprenorphine
description	Nalini Vadivelu, Roberta L HinesDepartment of Anesthesiology, Yale University School of Medicine, New Haven, USAAbstract: Chronic pain in the elderly is a significant problem. Pharmacokinetic and metabolic changes associated with increased age makes the elderly vulnerable to side effects and overdosing associated with analgesic agents. Therefore the management of chronic cancer pain and chronic nonmalignant pain in this growing population is an ongoing challenge. New routes of administration have opened up new treatment options to meet this challenge. The transdermal buprenorphine matrix allows for slow release of buprenorphine and damage does not produce dose dumping. In addition the long-acting analgesic property and relative safety profile makes it a suitable choice for the treatment of chronic pain in the elderly. Its safe use in the presence of renal failure makes it an attractive choice for older individuals. Recent scientific studies have shown no evidence of a ceiling dose of analgesia in man but only a ceiling effect for respiratory depression, increasing its safety profile. It appears that transdermal buprenorphine can be used in clinical practice safely and efficaciously for treating chronic pain in the elderly.Keywords: transdermal buprenorphine, chronic pain, elderly
format	article
author	Nalini Vadivelu Roberta L Hines
author_facet	Nalini Vadivelu Roberta L Hines
author_sort	Nalini Vadivelu
title	Management of chronic pain in the elderly: focus on transdermal buprenorphine
title_short	Management of chronic pain in the elderly: focus on transdermal buprenorphine
title_full	Management of chronic pain in the elderly: focus on transdermal buprenorphine
title_fullStr	Management of chronic pain in the elderly: focus on transdermal buprenorphine
title_full_unstemmed	Management of chronic pain in the elderly: focus on transdermal buprenorphine
title_sort	management of chronic pain in the elderly: focus on transdermal buprenorphine
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/d78673b555b34c6eb9fd9b4957f7ecea
work_keys_str_mv	AT nalinivadivelu managementofchronicpainintheelderlyfocusontransdermalbuprenorphine AT robertalhines managementofchronicpainintheelderlyfocusontransdermalbuprenorphine
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Management of chronic pain in the elderly: focus on transdermal buprenorphine

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