Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation

The evolutionarily conserved multifunctional polymerase-associated factor 1 (Paf1) complex plays an essential role in gene regulation. Here, the authors report two structures of the human and yeast Ctr9/Paf1 subcomplexes, and find that this is essential for Paf1 complex assembly and function.

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Autores principales:	Ying Xie, Minying Zheng, Xinlei Chu, Yue Chen, Huisha Xu, Jiawei Wang, Hao Zhou, Jiafu Long
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d788840a7dc24897813c51ea585601c8
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spelling	oai:doaj.org-article:d788840a7dc24897813c51ea585601c82021-12-02T16:49:32ZPaf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation10.1038/s41467-018-06237-72041-1723https://doaj.org/article/d788840a7dc24897813c51ea585601c82018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06237-7https://doaj.org/toc/2041-1723The evolutionarily conserved multifunctional polymerase-associated factor 1 (Paf1) complex plays an essential role in gene regulation. Here, the authors report two structures of the human and yeast Ctr9/Paf1 subcomplexes, and find that this is essential for Paf1 complex assembly and function.Ying XieMinying ZhengXinlei ChuYue ChenHuisha XuJiawei WangHao ZhouJiafu LongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ying Xie Minying Zheng Xinlei Chu Yue Chen Huisha Xu Jiawei Wang Hao Zhou Jiafu Long Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation
description	The evolutionarily conserved multifunctional polymerase-associated factor 1 (Paf1) complex plays an essential role in gene regulation. Here, the authors report two structures of the human and yeast Ctr9/Paf1 subcomplexes, and find that this is essential for Paf1 complex assembly and function.
format	article
author	Ying Xie Minying Zheng Xinlei Chu Yue Chen Huisha Xu Jiawei Wang Hao Zhou Jiafu Long
author_facet	Ying Xie Minying Zheng Xinlei Chu Yue Chen Huisha Xu Jiawei Wang Hao Zhou Jiafu Long
author_sort	Ying Xie
title	Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation
title_short	Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation
title_full	Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation
title_fullStr	Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation
title_full_unstemmed	Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation
title_sort	paf1 and ctr9 subcomplex formation is essential for paf1 complex assembly and functional regulation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d788840a7dc24897813c51ea585601c8
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Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation

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