Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation

The evolutionarily conserved multifunctional polymerase-associated factor 1 (Paf1) complex plays an essential role in gene regulation. Here, the authors report two structures of the human and yeast Ctr9/Paf1 subcomplexes, and find that this is essential for Paf1 complex assembly and function.

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Autores principales: Ying Xie, Minying Zheng, Xinlei Chu, Yue Chen, Huisha Xu, Jiawei Wang, Hao Zhou, Jiafu Long
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/d788840a7dc24897813c51ea585601c8
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