Diabetes and Colorectal Cancer Risk: A New Look at Molecular Mechanisms and Potential Role of Novel Antidiabetic Agents

Epidemiological data have demonstrated a significant association between the presence of type 2 diabetes mellitus (T2DM) and the development of colorectal cancer (CRC). Chronic hyperglycemia, insulin resistance, oxidative stress, and inflammation, the processes inherent to T2DM, also play active rol...

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Autores principales:	Jelena Vekic, Aleksandra Zeljkovic, Aleksandra Stefanovic, Rosaria Vincenza Giglio, Marcello Ciaccio, Manfredi Rizzo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	insulin resistance hyperglycemia oxidative stress inflammation small dense LDL glucagon-like peptide-1 receptor agonists Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d789fe012af54893836fdd938c2a60f2
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spelling	oai:doaj.org-article:d789fe012af54893836fdd938c2a60f22021-11-25T17:56:26ZDiabetes and Colorectal Cancer Risk: A New Look at Molecular Mechanisms and Potential Role of Novel Antidiabetic Agents10.3390/ijms2222124091422-00671661-6596https://doaj.org/article/d789fe012af54893836fdd938c2a60f22021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12409https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Epidemiological data have demonstrated a significant association between the presence of type 2 diabetes mellitus (T2DM) and the development of colorectal cancer (CRC). Chronic hyperglycemia, insulin resistance, oxidative stress, and inflammation, the processes inherent to T2DM, also play active roles in the onset and progression of CRC. Recently, small dense low-density lipoprotein (LDL) particles, a typical characteristic of diabetic dyslipidemia, emerged as another possible underlying link between T2DM and CRC. Growing evidence suggests that antidiabetic medications may have beneficial effects in CRC prevention. According to findings from a limited number of preclinical and clinical studies, glucagon-like peptide-1 receptor agonists (GLP-1RAs) could be a promising strategy in reducing the incidence of CRC in patients with diabetes. However, available findings are inconclusive, and further studies are required. In this review, novel evidence on molecular mechanisms linking T2DM with CRC development, progression, and survival will be discussed. In addition, the potential role of GLP-1RAs therapies in CRC prevention will also be evaluated.Jelena VekicAleksandra ZeljkovicAleksandra StefanovicRosaria Vincenza GiglioMarcello CiaccioManfredi RizzoMDPI AGarticleinsulin resistancehyperglycemiaoxidative stressinflammationsmall dense LDLglucagon-like peptide-1 receptor agonistsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12409, p 12409 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	insulin resistance hyperglycemia oxidative stress inflammation small dense LDL glucagon-like peptide-1 receptor agonists Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	insulin resistance hyperglycemia oxidative stress inflammation small dense LDL glucagon-like peptide-1 receptor agonists Biology (General) QH301-705.5 Chemistry QD1-999 Jelena Vekic Aleksandra Zeljkovic Aleksandra Stefanovic Rosaria Vincenza Giglio Marcello Ciaccio Manfredi Rizzo Diabetes and Colorectal Cancer Risk: A New Look at Molecular Mechanisms and Potential Role of Novel Antidiabetic Agents
description	Epidemiological data have demonstrated a significant association between the presence of type 2 diabetes mellitus (T2DM) and the development of colorectal cancer (CRC). Chronic hyperglycemia, insulin resistance, oxidative stress, and inflammation, the processes inherent to T2DM, also play active roles in the onset and progression of CRC. Recently, small dense low-density lipoprotein (LDL) particles, a typical characteristic of diabetic dyslipidemia, emerged as another possible underlying link between T2DM and CRC. Growing evidence suggests that antidiabetic medications may have beneficial effects in CRC prevention. According to findings from a limited number of preclinical and clinical studies, glucagon-like peptide-1 receptor agonists (GLP-1RAs) could be a promising strategy in reducing the incidence of CRC in patients with diabetes. However, available findings are inconclusive, and further studies are required. In this review, novel evidence on molecular mechanisms linking T2DM with CRC development, progression, and survival will be discussed. In addition, the potential role of GLP-1RAs therapies in CRC prevention will also be evaluated.
format	article
author	Jelena Vekic Aleksandra Zeljkovic Aleksandra Stefanovic Rosaria Vincenza Giglio Marcello Ciaccio Manfredi Rizzo
author_facet	Jelena Vekic Aleksandra Zeljkovic Aleksandra Stefanovic Rosaria Vincenza Giglio Marcello Ciaccio Manfredi Rizzo
author_sort	Jelena Vekic
title	Diabetes and Colorectal Cancer Risk: A New Look at Molecular Mechanisms and Potential Role of Novel Antidiabetic Agents
title_short	Diabetes and Colorectal Cancer Risk: A New Look at Molecular Mechanisms and Potential Role of Novel Antidiabetic Agents
title_full	Diabetes and Colorectal Cancer Risk: A New Look at Molecular Mechanisms and Potential Role of Novel Antidiabetic Agents
title_fullStr	Diabetes and Colorectal Cancer Risk: A New Look at Molecular Mechanisms and Potential Role of Novel Antidiabetic Agents
title_full_unstemmed	Diabetes and Colorectal Cancer Risk: A New Look at Molecular Mechanisms and Potential Role of Novel Antidiabetic Agents
title_sort	diabetes and colorectal cancer risk: a new look at molecular mechanisms and potential role of novel antidiabetic agents
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d789fe012af54893836fdd938c2a60f2
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Diabetes and Colorectal Cancer Risk: A New Look at Molecular Mechanisms and Potential Role of Novel Antidiabetic Agents

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