Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

Abstract Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are closely related to a variety of...

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Autores principales:	Chen Li, Yu-Qing Ni, Hui Xu, Qun-Yan Xiang, Yan Zhao, Jun-Kun Zhan, Jie-Yu He, Shuang Li, You-Shuo Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d78d97473e6e486fbcce13f6b6709a08
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spelling	oai:doaj.org-article:d78d97473e6e486fbcce13f6b6709a082021-11-14T12:10:42ZRoles and mechanisms of exosomal non-coding RNAs in human health and diseases10.1038/s41392-021-00779-x2059-3635https://doaj.org/article/d78d97473e6e486fbcce13f6b6709a082021-11-01T00:00:00Zhttps://doi.org/10.1038/s41392-021-00779-xhttps://doaj.org/toc/2059-3635Abstract Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are closely related to a variety of biological and functional aspects of human health. When the exosomal ncRNAs undergo tissue-specific changes due to diverse internal or external disorders, they can cause tissue dysfunction, aging, and diseases. In this review, we comprehensively discuss the underlying regulatory mechanisms of exosomes in human diseases. In addition, we explore the current knowledge on the roles of exosomal miRNAs, lncRNAs, and circRNAs in human health and diseases, including cancers, metabolic diseases, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and infectious diseases, to determine their potential implication in biomarker identification and therapeutic exploration.Chen LiYu-Qing NiHui XuQun-Yan XiangYan ZhaoJun-Kun ZhanJie-Yu HeShuang LiYou-Shuo LiuNature Publishing GrouparticleMedicineRBiology (General)QH301-705.5ENSignal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-31 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biology (General) QH301-705.5
spellingShingle	Medicine R Biology (General) QH301-705.5 Chen Li Yu-Qing Ni Hui Xu Qun-Yan Xiang Yan Zhao Jun-Kun Zhan Jie-Yu He Shuang Li You-Shuo Liu Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
description	Abstract Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are closely related to a variety of biological and functional aspects of human health. When the exosomal ncRNAs undergo tissue-specific changes due to diverse internal or external disorders, they can cause tissue dysfunction, aging, and diseases. In this review, we comprehensively discuss the underlying regulatory mechanisms of exosomes in human diseases. In addition, we explore the current knowledge on the roles of exosomal miRNAs, lncRNAs, and circRNAs in human health and diseases, including cancers, metabolic diseases, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and infectious diseases, to determine their potential implication in biomarker identification and therapeutic exploration.
format	article
author	Chen Li Yu-Qing Ni Hui Xu Qun-Yan Xiang Yan Zhao Jun-Kun Zhan Jie-Yu He Shuang Li You-Shuo Liu
author_facet	Chen Li Yu-Qing Ni Hui Xu Qun-Yan Xiang Yan Zhao Jun-Kun Zhan Jie-Yu He Shuang Li You-Shuo Liu
author_sort	Chen Li
title	Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
title_short	Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
title_full	Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
title_fullStr	Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
title_full_unstemmed	Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
title_sort	roles and mechanisms of exosomal non-coding rnas in human health and diseases
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/d78d97473e6e486fbcce13f6b6709a08
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Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

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