Pattern analysis for prognosis of differentiated thyroid cancer according to preoperative serum thyrotropin levels

Abstract Serum thyrotropin (TSH) level after thyroid surgery affects the prognosis of differentiated thyroid cancer (DTC). However, the effects of preoperative serum TSH levels on the prognosis of DTC remain contradictory. In this study, to better understand the relationship between preoperative TSH...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hosu Kim, Jaehoon Jung, Young-Seok Cho, Joon Young Choi, Hyunju Park, You-Bin Lee, Sun Wook Kim, Jae Hoon Chung, Tae Hyuk Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d78f130775b14d349e6171716e3fed99
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d78f130775b14d349e6171716e3fed99
record_format	dspace
spelling	oai:doaj.org-article:d78f130775b14d349e6171716e3fed992021-11-21T12:24:34ZPattern analysis for prognosis of differentiated thyroid cancer according to preoperative serum thyrotropin levels10.1038/s41598-021-01898-92045-2322https://doaj.org/article/d78f130775b14d349e6171716e3fed992021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01898-9https://doaj.org/toc/2045-2322Abstract Serum thyrotropin (TSH) level after thyroid surgery affects the prognosis of differentiated thyroid cancer (DTC). However, the effects of preoperative serum TSH levels on the prognosis of DTC remain contradictory. In this study, to better understand the relationship between preoperative TSH levels and the prognosis of DTC, we performed pattern analysis of prognostic factors of DTC according to preoperative serum TSH levels. We retrospectively reviewed the clinical records of patients who were diagnosed and treated for DTC at the Samsung Medical Center, between 1994 and 2016. We reviewed preoperative serum TSH levels and performed a pattern analysis with prognostic risk factors for DTC. For pattern analysis, TSH was divided into 10 groups of equal fractions (TSH decile). We found a linear association between preoperative TSH levels and extra-thyroidal extension and lymph node metastasis. However, primary tumor size and initial distant metastasis showed a bimodal peak, which was similar to the pattern of overall and disease-specific death. We found that preoperative TSH range which showed the lowest mortality rate was about 0.8 to 1.59 mIU/L, which are slightly lower normal TSH levels. Although there was no linear trend, the primary tumor size, initial distant metastasis, and mortality of DTC were closely related with preoperative TSH decile and they showed a bimodal pattern. The results obtained in this study provide additional information for understanding the association between preoperative TSH levels and DTC prognosis.Hosu KimJaehoon JungYoung-Seok ChoJoon Young ChoiHyunju ParkYou-Bin LeeSun Wook KimJae Hoon ChungTae Hyuk KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hosu Kim Jaehoon Jung Young-Seok Cho Joon Young Choi Hyunju Park You-Bin Lee Sun Wook Kim Jae Hoon Chung Tae Hyuk Kim Pattern analysis for prognosis of differentiated thyroid cancer according to preoperative serum thyrotropin levels
description	Abstract Serum thyrotropin (TSH) level after thyroid surgery affects the prognosis of differentiated thyroid cancer (DTC). However, the effects of preoperative serum TSH levels on the prognosis of DTC remain contradictory. In this study, to better understand the relationship between preoperative TSH levels and the prognosis of DTC, we performed pattern analysis of prognostic factors of DTC according to preoperative serum TSH levels. We retrospectively reviewed the clinical records of patients who were diagnosed and treated for DTC at the Samsung Medical Center, between 1994 and 2016. We reviewed preoperative serum TSH levels and performed a pattern analysis with prognostic risk factors for DTC. For pattern analysis, TSH was divided into 10 groups of equal fractions (TSH decile). We found a linear association between preoperative TSH levels and extra-thyroidal extension and lymph node metastasis. However, primary tumor size and initial distant metastasis showed a bimodal peak, which was similar to the pattern of overall and disease-specific death. We found that preoperative TSH range which showed the lowest mortality rate was about 0.8 to 1.59 mIU/L, which are slightly lower normal TSH levels. Although there was no linear trend, the primary tumor size, initial distant metastasis, and mortality of DTC were closely related with preoperative TSH decile and they showed a bimodal pattern. The results obtained in this study provide additional information for understanding the association between preoperative TSH levels and DTC prognosis.
format	article
author	Hosu Kim Jaehoon Jung Young-Seok Cho Joon Young Choi Hyunju Park You-Bin Lee Sun Wook Kim Jae Hoon Chung Tae Hyuk Kim
author_facet	Hosu Kim Jaehoon Jung Young-Seok Cho Joon Young Choi Hyunju Park You-Bin Lee Sun Wook Kim Jae Hoon Chung Tae Hyuk Kim
author_sort	Hosu Kim
title	Pattern analysis for prognosis of differentiated thyroid cancer according to preoperative serum thyrotropin levels
title_short	Pattern analysis for prognosis of differentiated thyroid cancer according to preoperative serum thyrotropin levels
title_full	Pattern analysis for prognosis of differentiated thyroid cancer according to preoperative serum thyrotropin levels
title_fullStr	Pattern analysis for prognosis of differentiated thyroid cancer according to preoperative serum thyrotropin levels
title_full_unstemmed	Pattern analysis for prognosis of differentiated thyroid cancer according to preoperative serum thyrotropin levels
title_sort	pattern analysis for prognosis of differentiated thyroid cancer according to preoperative serum thyrotropin levels
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d78f130775b14d349e6171716e3fed99
work_keys_str_mv	AT hosukim patternanalysisforprognosisofdifferentiatedthyroidcanceraccordingtopreoperativeserumthyrotropinlevels AT jaehoonjung patternanalysisforprognosisofdifferentiatedthyroidcanceraccordingtopreoperativeserumthyrotropinlevels AT youngseokcho patternanalysisforprognosisofdifferentiatedthyroidcanceraccordingtopreoperativeserumthyrotropinlevels AT joonyoungchoi patternanalysisforprognosisofdifferentiatedthyroidcanceraccordingtopreoperativeserumthyrotropinlevels AT hyunjupark patternanalysisforprognosisofdifferentiatedthyroidcanceraccordingtopreoperativeserumthyrotropinlevels AT youbinlee patternanalysisforprognosisofdifferentiatedthyroidcanceraccordingtopreoperativeserumthyrotropinlevels AT sunwookkim patternanalysisforprognosisofdifferentiatedthyroidcanceraccordingtopreoperativeserumthyrotropinlevels AT jaehoonchung patternanalysisforprognosisofdifferentiatedthyroidcanceraccordingtopreoperativeserumthyrotropinlevels AT taehyukkim patternanalysisforprognosisofdifferentiatedthyroidcanceraccordingtopreoperativeserumthyrotropinlevels
_version_	1718419034451476480

Pattern analysis for prognosis of differentiated thyroid cancer according to preoperative serum thyrotropin levels

Ejemplares similares