HPV Testing for Cervical Cancer in Romania: High-Risk HPV Prevalence among Ethnic Subpopulations and Regions

Background: Romania has had one of the highest rates of cervical cancer incidence and mortality in Europe for decades. Data on the high-risk human papillomavirus (hrHPV) prevalence within the Romanian population are crucial for cervical cancer intervention in high risk groups. The aim of this study...

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Autores principales:	Minodora Bianca Ilisiu, Dana Hashim, Trude Andreassen, Nathalie C. Støer, Florian Nicula, Elisabete Weiderpass
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2019
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/d7917aa97cbe4214a853bd7fd9c84384
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spelling	oai:doaj.org-article:d7917aa97cbe4214a853bd7fd9c843842021-12-02T06:36:05ZHPV Testing for Cervical Cancer in Romania: High-Risk HPV Prevalence among Ethnic Subpopulations and Regions2214-999610.5334/aogh.2502https://doaj.org/article/d7917aa97cbe4214a853bd7fd9c843842019-06-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/2502https://doaj.org/toc/2214-9996Background: Romania has had one of the highest rates of cervical cancer incidence and mortality in Europe for decades. Data on the high-risk human papillomavirus (hrHPV) prevalence within the Romanian population are crucial for cervical cancer intervention in high risk groups. The aim of this study was to determine the prevalence of hrHPV infection in Romania, identifying high-risk areas for cervical cancer prevention efforts. Methods: The target population of this study were women of all forms in Romania, including ethnic minorities, women from urban and rural areas, and women in various regions. Women with no history of precancerous or cancerous lesions were offered hrHPV screening. The specimens were tested with Hybrid Capture 2 (HC2) DNA test. Age-standardized hrHPV prevalence rates with 95% confidence intervals (CI) were estimated. Results: hrHPV results of 2060 women aged 18 to 70 years were analyzed. The highest hrHPV prevalence rates were observed among: Romanians (17.9%; 95 CI: 15.5–20.7%), Hungarians (16.6%; 95% CI: 13.1–20.8%), Russians (15.6%; 95% CI: 11.3–21.3%), women living in North (19.2%; 95% CI: 16.5–22.3%), and West regions (23.0%; 95 CI: 18.6–28.0%), and women living in urban areas (20.0%; 95 CI: 18.5–28.0%). hrHPV prevalence rates were lower for the Roma population (7.8%; 95% CI: 4.7–12.5%). Conclusions: These hrHPV prevalence rates in a high cervical cancer incidence country provide baseline information for targeted cervical cancer intervention strategies as well as a baseline to measure the impact of hrHPV vaccination in the future.Minodora Bianca IlisiuDana HashimTrude AndreassenNathalie C. StøerFlorian NiculaElisabete WeiderpassUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 85, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Minodora Bianca Ilisiu Dana Hashim Trude Andreassen Nathalie C. Støer Florian Nicula Elisabete Weiderpass HPV Testing for Cervical Cancer in Romania: High-Risk HPV Prevalence among Ethnic Subpopulations and Regions
description	Background: Romania has had one of the highest rates of cervical cancer incidence and mortality in Europe for decades. Data on the high-risk human papillomavirus (hrHPV) prevalence within the Romanian population are crucial for cervical cancer intervention in high risk groups. The aim of this study was to determine the prevalence of hrHPV infection in Romania, identifying high-risk areas for cervical cancer prevention efforts. Methods: The target population of this study were women of all forms in Romania, including ethnic minorities, women from urban and rural areas, and women in various regions. Women with no history of precancerous or cancerous lesions were offered hrHPV screening. The specimens were tested with Hybrid Capture 2 (HC2) DNA test. Age-standardized hrHPV prevalence rates with 95% confidence intervals (CI) were estimated. Results: hrHPV results of 2060 women aged 18 to 70 years were analyzed. The highest hrHPV prevalence rates were observed among: Romanians (17.9%; 95 CI: 15.5–20.7%), Hungarians (16.6%; 95% CI: 13.1–20.8%), Russians (15.6%; 95% CI: 11.3–21.3%), women living in North (19.2%; 95% CI: 16.5–22.3%), and West regions (23.0%; 95 CI: 18.6–28.0%), and women living in urban areas (20.0%; 95 CI: 18.5–28.0%). hrHPV prevalence rates were lower for the Roma population (7.8%; 95% CI: 4.7–12.5%). Conclusions: These hrHPV prevalence rates in a high cervical cancer incidence country provide baseline information for targeted cervical cancer intervention strategies as well as a baseline to measure the impact of hrHPV vaccination in the future.
format	article
author	Minodora Bianca Ilisiu Dana Hashim Trude Andreassen Nathalie C. Støer Florian Nicula Elisabete Weiderpass
author_facet	Minodora Bianca Ilisiu Dana Hashim Trude Andreassen Nathalie C. Støer Florian Nicula Elisabete Weiderpass
author_sort	Minodora Bianca Ilisiu
title	HPV Testing for Cervical Cancer in Romania: High-Risk HPV Prevalence among Ethnic Subpopulations and Regions
title_short	HPV Testing for Cervical Cancer in Romania: High-Risk HPV Prevalence among Ethnic Subpopulations and Regions
title_full	HPV Testing for Cervical Cancer in Romania: High-Risk HPV Prevalence among Ethnic Subpopulations and Regions
title_fullStr	HPV Testing for Cervical Cancer in Romania: High-Risk HPV Prevalence among Ethnic Subpopulations and Regions
title_full_unstemmed	HPV Testing for Cervical Cancer in Romania: High-Risk HPV Prevalence among Ethnic Subpopulations and Regions
title_sort	hpv testing for cervical cancer in romania: high-risk hpv prevalence among ethnic subpopulations and regions
publisher	Ubiquity Press
publishDate	2019
url	https://doaj.org/article/d7917aa97cbe4214a853bd7fd9c84384
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HPV Testing for Cervical Cancer in Romania: High-Risk HPV Prevalence among Ethnic Subpopulations and Regions

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