Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome

Tourette syndrome results from a complex interaction between social–environmental factors, multiple genetic abnormalities, and neurotransmitter disturbances. This study is a double-blinded, randomized controlled trial using probiotics <i>Lactobacillus plantarum</i> PS128 as an interventi...

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Autores principales:	Chang-Chun Wu, Lee-Chin Wong, Chia-Jui Hsu, Chianne-Wen Yang, Ying-Chieh Tsai, Feng-Shiang Cheng, Hsiao-Yun Hu, Wang-Tso Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tics probiotics PS128 Tourette syndrome attention deficit hyperactivity disorder children Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/d792692320a448dcb69015ace86df4f5
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spelling	oai:doaj.org-article:d792692320a448dcb69015ace86df4f52021-11-25T18:33:16ZRandomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome10.3390/nu131136982072-6643https://doaj.org/article/d792692320a448dcb69015ace86df4f52021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3698https://doaj.org/toc/2072-6643Tourette syndrome results from a complex interaction between social–environmental factors, multiple genetic abnormalities, and neurotransmitter disturbances. This study is a double-blinded, randomized controlled trial using probiotics <i>Lactobacillus plantarum</i> PS128 as an intervention to examine if probiotics improve symptoms of children with Tourette syndrome. This study enrolled children aged 5 to 18 years old who fulfilled DSM-V diagnostic criteria for Tourette syndrome. Patients were assessed before initiating the trial, at one month, and at two months after randomization. The primary outcome was evaluated by Yale Global Tic Severity Scale (YGTSS), and the secondary outcome studied the possible comorbidities in these children. The results revealed no significant difference in improvement in YGTSS between the control group and the PS128 group. As for secondary endpoints, an analysis of Conners’ Continuous Performance Test (CPT) showed improvement in commission and detectability in the PS128 group. In conclusion, although probiotics may not have tic-reducing effects in children with Tourette syndrome, it may have benefits on comorbidities such as attention deficit and hyperactivity disorder (ADHD). Further studies are needed to clarify the effects of probiotics on the comorbidities of Tourette syndrome children.Chang-Chun WuLee-Chin WongChia-Jui HsuChianne-Wen YangYing-Chieh TsaiFeng-Shiang ChengHsiao-Yun HuWang-Tso LeeMDPI AGarticleticsprobiotics PS128Tourette syndromeattention deficit hyperactivity disorderchildrenNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3698, p 3698 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tics probiotics PS128 Tourette syndrome attention deficit hyperactivity disorder children Nutrition. Foods and food supply TX341-641
spellingShingle	tics probiotics PS128 Tourette syndrome attention deficit hyperactivity disorder children Nutrition. Foods and food supply TX341-641 Chang-Chun Wu Lee-Chin Wong Chia-Jui Hsu Chianne-Wen Yang Ying-Chieh Tsai Feng-Shiang Cheng Hsiao-Yun Hu Wang-Tso Lee Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
description	Tourette syndrome results from a complex interaction between social–environmental factors, multiple genetic abnormalities, and neurotransmitter disturbances. This study is a double-blinded, randomized controlled trial using probiotics <i>Lactobacillus plantarum</i> PS128 as an intervention to examine if probiotics improve symptoms of children with Tourette syndrome. This study enrolled children aged 5 to 18 years old who fulfilled DSM-V diagnostic criteria for Tourette syndrome. Patients were assessed before initiating the trial, at one month, and at two months after randomization. The primary outcome was evaluated by Yale Global Tic Severity Scale (YGTSS), and the secondary outcome studied the possible comorbidities in these children. The results revealed no significant difference in improvement in YGTSS between the control group and the PS128 group. As for secondary endpoints, an analysis of Conners’ Continuous Performance Test (CPT) showed improvement in commission and detectability in the PS128 group. In conclusion, although probiotics may not have tic-reducing effects in children with Tourette syndrome, it may have benefits on comorbidities such as attention deficit and hyperactivity disorder (ADHD). Further studies are needed to clarify the effects of probiotics on the comorbidities of Tourette syndrome children.
format	article
author	Chang-Chun Wu Lee-Chin Wong Chia-Jui Hsu Chianne-Wen Yang Ying-Chieh Tsai Feng-Shiang Cheng Hsiao-Yun Hu Wang-Tso Lee
author_facet	Chang-Chun Wu Lee-Chin Wong Chia-Jui Hsu Chianne-Wen Yang Ying-Chieh Tsai Feng-Shiang Cheng Hsiao-Yun Hu Wang-Tso Lee
author_sort	Chang-Chun Wu
title	Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
title_short	Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
title_full	Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
title_fullStr	Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
title_full_unstemmed	Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome
title_sort	randomized controlled trial of probiotic ps128 in children with tourette syndrome
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d792692320a448dcb69015ace86df4f5
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Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome

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