Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling

Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling

Optogenetic tools have been used to control cellular behaviours but their use to probe structure-function relations of signalling proteins are underexplored. Here the authors engineer optogenetic modules into STIM1 to dissect molecular details of STIM1-mediated signalling and control various cellula...

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Autores principales: Guolin Ma, Lian He, Shuzhong Liu, Jiansheng Xie, Zixian Huang, Ji Jing, Yi-Tsang Lee, Rui Wang, Hesheng Luo, Weidong Han, Yun Huang, Yubin Zhou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d794e4ce185f4e5981a7283cbeabcec0
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spelling oai:doaj.org-article:d794e4ce185f4e5981a7283cbeabcec02021-12-02T17:32:41ZOptogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling10.1038/s41467-020-14841-92041-1723https://doaj.org/article/d794e4ce185f4e5981a7283cbeabcec02020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14841-9https://doaj.org/toc/2041-1723Optogenetic tools have been used to control cellular behaviours but their use to probe structure-function relations of signalling proteins are underexplored. Here the authors engineer optogenetic modules into STIM1 to dissect molecular details of STIM1-mediated signalling and control various cellular events.Guolin MaLian HeShuzhong LiuJiansheng XieZixian HuangJi JingYi-Tsang LeeRui WangHesheng LuoWeidong HanYun HuangYubin ZhouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Guolin Ma
Lian He
Shuzhong Liu
Jiansheng Xie
Zixian Huang
Ji Jing
Yi-Tsang Lee
Rui Wang
Hesheng Luo
Weidong Han
Yun Huang
Yubin Zhou
Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
description Optogenetic tools have been used to control cellular behaviours but their use to probe structure-function relations of signalling proteins are underexplored. Here the authors engineer optogenetic modules into STIM1 to dissect molecular details of STIM1-mediated signalling and control various cellular events.
format article
author Guolin Ma
Lian He
Shuzhong Liu
Jiansheng Xie
Zixian Huang
Ji Jing
Yi-Tsang Lee
Rui Wang
Hesheng Luo
Weidong Han
Yun Huang
Yubin Zhou
author_facet Guolin Ma
Lian He
Shuzhong Liu
Jiansheng Xie
Zixian Huang
Ji Jing
Yi-Tsang Lee
Rui Wang
Hesheng Luo
Weidong Han
Yun Huang
Yubin Zhou
author_sort Guolin Ma
title Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
title_short Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
title_full Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
title_fullStr Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
title_full_unstemmed Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling
title_sort optogenetic engineering to probe the molecular choreography of stim1-mediated cell signaling
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/d794e4ce185f4e5981a7283cbeabcec0
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