Spontaneous alterations of regional brain activity in patients with adult generalized anxiety disorder

Likun Xia,1 Shumei Li,2 Tianyue Wang,2 Yaping Guo,3 Lihong Meng,3 Yunping Feng,3 Yu Cui,1 Fan Wang,1 Jian Ma,1 Guihua Jiang2 1Department of Magnetic Resonance Imaging, People’s Hospital of Yuxi City, Yuxi, 2Department of Medical Imaging, Guangdong No 2 Provincial People’s Hospit...

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Autores principales:	Xia L, Li S, Wang T, Guo Y, Meng L, Feng Y, Cui Y, Wang F, Ma J, Jiang G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Generalized anxiety disorder Functional magnetic resonance imaging Resting-state Regional homogeneity. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d79a00c52d62459797d643365a24b683
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spelling	oai:doaj.org-article:d79a00c52d62459797d643365a24b6832021-12-02T06:32:06ZSpontaneous alterations of regional brain activity in patients with adult generalized anxiety disorder1178-2021https://doaj.org/article/d79a00c52d62459797d643365a24b6832017-07-01T00:00:00Zhttps://www.dovepress.com/spontaneous-alterations-of-regional-brain-activity-in-patients-with-ad-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Likun Xia,1 Shumei Li,2 Tianyue Wang,2 Yaping Guo,3 Lihong Meng,3 Yunping Feng,3 Yu Cui,1 Fan Wang,1 Jian Ma,1 Guihua Jiang2 1Department of Magnetic Resonance Imaging, People’s Hospital of Yuxi City, Yuxi, 2Department of Medical Imaging, Guangdong No 2 Provincial People’s Hospital, Guangzhou, 3Department of Rehabilitation Medicine, People’s Hospital of Yuxi City, Yuxi, People’s Republic of China Objective: We aimed to examine how spontaneous brain activity might be related to the pathophysiology of generalized anxiety disorder (GAD).Patients and methods: Using resting-state functional MRI, we examined spontaneous regional brain activity in 31 GAD patients (mean age, 36.87±9.16 years) and 36 healthy control participants (mean age, 39.53±8.83 years) matched for age, education, and sex from December 2014 to October 2015. We performed a two-sample t-test on the voxel-based analysis of the regional homogeneity (ReHo) maps. We used Pearson correlation analysis to compare scores from the Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale, State–Trait Anxiety Scale-Trait Scale, and mean ReHo values.Results: We found abnormal spontaneous activity in multiple regions of brain in GAD patients, especially in the sensorimotor cortex and emotional regions. GAD patients showed decreased ReHo values in the right orbital middle frontal gyrus, left anterior cingulate cortex, right middle frontal gyrus, and bilateral supplementary motor areas, with increased ReHo values in the left middle temporal gyrus, left superior temporal gyrus, and right superior occipital gyrus. The ReHo value of the left middle temporal gyrus correlated positively with the Hamilton Anxiety Rating Scale scores.Conclusion: These results suggest that altered local synchronization of spontaneous brain activity may be related to the pathophysiology of GAD. Keywords: generalized anxiety disorder, functional magnetic resonance imaging, resting state, regional homogeneityXia LLi SWang TGuo YMeng LFeng YCui YWang FMa JJiang GDove Medical PressarticleGeneralized anxiety disorderFunctional magnetic resonance imagingResting-stateRegional homogeneity.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1957-1965 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Generalized anxiety disorder Functional magnetic resonance imaging Resting-state Regional homogeneity. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Generalized anxiety disorder Functional magnetic resonance imaging Resting-state Regional homogeneity. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xia L Li S Wang T Guo Y Meng L Feng Y Cui Y Wang F Ma J Jiang G Spontaneous alterations of regional brain activity in patients with adult generalized anxiety disorder
description	Likun Xia,1 Shumei Li,2 Tianyue Wang,2 Yaping Guo,3 Lihong Meng,3 Yunping Feng,3 Yu Cui,1 Fan Wang,1 Jian Ma,1 Guihua Jiang2 1Department of Magnetic Resonance Imaging, People’s Hospital of Yuxi City, Yuxi, 2Department of Medical Imaging, Guangdong No 2 Provincial People’s Hospital, Guangzhou, 3Department of Rehabilitation Medicine, People’s Hospital of Yuxi City, Yuxi, People’s Republic of China Objective: We aimed to examine how spontaneous brain activity might be related to the pathophysiology of generalized anxiety disorder (GAD).Patients and methods: Using resting-state functional MRI, we examined spontaneous regional brain activity in 31 GAD patients (mean age, 36.87±9.16 years) and 36 healthy control participants (mean age, 39.53±8.83 years) matched for age, education, and sex from December 2014 to October 2015. We performed a two-sample t-test on the voxel-based analysis of the regional homogeneity (ReHo) maps. We used Pearson correlation analysis to compare scores from the Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale, State–Trait Anxiety Scale-Trait Scale, and mean ReHo values.Results: We found abnormal spontaneous activity in multiple regions of brain in GAD patients, especially in the sensorimotor cortex and emotional regions. GAD patients showed decreased ReHo values in the right orbital middle frontal gyrus, left anterior cingulate cortex, right middle frontal gyrus, and bilateral supplementary motor areas, with increased ReHo values in the left middle temporal gyrus, left superior temporal gyrus, and right superior occipital gyrus. The ReHo value of the left middle temporal gyrus correlated positively with the Hamilton Anxiety Rating Scale scores.Conclusion: These results suggest that altered local synchronization of spontaneous brain activity may be related to the pathophysiology of GAD. Keywords: generalized anxiety disorder, functional magnetic resonance imaging, resting state, regional homogeneity
format	article
author	Xia L Li S Wang T Guo Y Meng L Feng Y Cui Y Wang F Ma J Jiang G
author_facet	Xia L Li S Wang T Guo Y Meng L Feng Y Cui Y Wang F Ma J Jiang G
author_sort	Xia L
title	Spontaneous alterations of regional brain activity in patients with adult generalized anxiety disorder
title_short	Spontaneous alterations of regional brain activity in patients with adult generalized anxiety disorder
title_full	Spontaneous alterations of regional brain activity in patients with adult generalized anxiety disorder
title_fullStr	Spontaneous alterations of regional brain activity in patients with adult generalized anxiety disorder
title_full_unstemmed	Spontaneous alterations of regional brain activity in patients with adult generalized anxiety disorder
title_sort	spontaneous alterations of regional brain activity in patients with adult generalized anxiety disorder
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/d79a00c52d62459797d643365a24b683
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Spontaneous alterations of regional brain activity in patients with adult generalized anxiety disorder

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