Anti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract

Context: Mollugo pentaphylla L. (Molluginaceae) extract (MPE) has been reported to have anti-inflammatory effect on MSU-induced gouty arthritis in a mouse model. Objective: This study examined the anti-inflammatory activities of an MPE in vitro and anti-osteoarthritis effects on monosodium iodoaceta...

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Autores principales:	Yun Mi Lee, Eunjung Son, Seung-Hyung Kim, Ohn Soon Kim, Dong-Seon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	osteoarthritis inflammation pain cartilage Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d79b5281211a4e669e929b8014d5f120
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spelling	oai:doaj.org-article:d79b5281211a4e669e929b8014d5f1202021-11-17T14:21:55ZAnti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract1388-02091744-511610.1080/13880209.2018.1557700https://doaj.org/article/d79b5281211a4e669e929b8014d5f1202019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2018.1557700https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Mollugo pentaphylla L. (Molluginaceae) extract (MPE) has been reported to have anti-inflammatory effect on MSU-induced gouty arthritis in a mouse model. Objective: This study examined the anti-inflammatory activities of an MPE in vitro and anti-osteoarthritis effects on monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in vivo. Materials and methods: The dried whole plants of M. pentaphylla were extracted with 70% ethanol under reflux. The anti-inflammatory effect of MPE was evaluated in vitro in lipopolysaccharide (LPS)-treated RAW264.7 cells. The anti-osteoarthritic effect of MPE was investigated in a Sprague–Dawley rat model of MIA-induced OA. Each seven male rats were orally administered MPE (75, 150 or 300 mg/kg) or the positive control drug indomethacin (1 mg/kg) 3 days before MIA injection and once daily for 11 days thereafter. After the treatment with MPE, no evidence of systemic adverse effects was observed in any study group. Results: MPE exhibited anti-inflammatory activity via inhibition of the production of NO (57.8%), PGE2 (97.1%) and IL-6 (93.2%) in LPS-treated RAW264.7 cells at 200 μg/mL. In addition, MPE suppressed IL-1β (60.9%), TNF-α (37.9%) and IL- 6 (40.9%) production and suppressed the synthesis of MMP-2, MMP-9 and COX-2 in the MIA-induced OA rat model. Conclusions: These results demonstrate that MPE exerts potent anti-inflammatory activities and protects cartilage in an OA rat model. This might be a potential candidate for therapeutic OA treatment.Yun Mi LeeEunjung SonSeung-Hyung KimOhn Soon KimDong-Seon KimTaylor & Francis GrouparticleosteoarthritisinflammationpaincartilageTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 73-80 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoarthritis inflammation pain cartilage Therapeutics. Pharmacology RM1-950
spellingShingle	osteoarthritis inflammation pain cartilage Therapeutics. Pharmacology RM1-950 Yun Mi Lee Eunjung Son Seung-Hyung Kim Ohn Soon Kim Dong-Seon Kim Anti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract
description	Context: Mollugo pentaphylla L. (Molluginaceae) extract (MPE) has been reported to have anti-inflammatory effect on MSU-induced gouty arthritis in a mouse model. Objective: This study examined the anti-inflammatory activities of an MPE in vitro and anti-osteoarthritis effects on monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in vivo. Materials and methods: The dried whole plants of M. pentaphylla were extracted with 70% ethanol under reflux. The anti-inflammatory effect of MPE was evaluated in vitro in lipopolysaccharide (LPS)-treated RAW264.7 cells. The anti-osteoarthritic effect of MPE was investigated in a Sprague–Dawley rat model of MIA-induced OA. Each seven male rats were orally administered MPE (75, 150 or 300 mg/kg) or the positive control drug indomethacin (1 mg/kg) 3 days before MIA injection and once daily for 11 days thereafter. After the treatment with MPE, no evidence of systemic adverse effects was observed in any study group. Results: MPE exhibited anti-inflammatory activity via inhibition of the production of NO (57.8%), PGE2 (97.1%) and IL-6 (93.2%) in LPS-treated RAW264.7 cells at 200 μg/mL. In addition, MPE suppressed IL-1β (60.9%), TNF-α (37.9%) and IL- 6 (40.9%) production and suppressed the synthesis of MMP-2, MMP-9 and COX-2 in the MIA-induced OA rat model. Conclusions: These results demonstrate that MPE exerts potent anti-inflammatory activities and protects cartilage in an OA rat model. This might be a potential candidate for therapeutic OA treatment.
format	article
author	Yun Mi Lee Eunjung Son Seung-Hyung Kim Ohn Soon Kim Dong-Seon Kim
author_facet	Yun Mi Lee Eunjung Son Seung-Hyung Kim Ohn Soon Kim Dong-Seon Kim
author_sort	Yun Mi Lee
title	Anti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract
title_short	Anti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract
title_full	Anti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract
title_fullStr	Anti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract
title_full_unstemmed	Anti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract
title_sort	anti-inflammatory and anti-osteoarthritis effect of mollugo pentaphylla extract
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/d79b5281211a4e669e929b8014d5f120
work_keys_str_mv	AT yunmilee antiinflammatoryandantiosteoarthritiseffectofmollugopentaphyllaextract AT eunjungson antiinflammatoryandantiosteoarthritiseffectofmollugopentaphyllaextract AT seunghyungkim antiinflammatoryandantiosteoarthritiseffectofmollugopentaphyllaextract AT ohnsoonkim antiinflammatoryandantiosteoarthritiseffectofmollugopentaphyllaextract AT dongseonkim antiinflammatoryandantiosteoarthritiseffectofmollugopentaphyllaextract
_version_	1718425512888500224

Anti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract

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