The scaffolding protein Dlg1 is a negative regulator of cell-free virus infectivity but not of cell-to-cell HIV-1 transmission in T cells.

<h4>Background</h4>Cell-to-cell virus transmission of Human immunodeficiency virus type-1 (HIV-1) is predominantly mediated by cellular structures such as the virological synapse (VS). The VS formed between an HIV-1-infected T cell and a target T cell shares features with the immunologic...

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Autores principales: Patrycja Nzounza, Maxime Chazal, Chloé Guedj, Alain Schmitt, Jean-Marc Massé, Clotilde Randriamampita, Claudine Pique, Bertha Cecilia Ramirez
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/d79bb46ba1474c938345a5386ad7b923
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