Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide

Irena R &Scaron;tenglová Netíková,1 Lubo&scaron; Petruželka,2,3 Martin &Scaron;tastný,1,2 Václav &Scaron;tengl1 1Department of Oncology, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prag...

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Autores principales:	Štenglová Netíková IR, Petruželka L, Šťastný M, Štengl V
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	cyclophosphamide ifosfamide ifosfamide mustard titanium(IV) dioxide degradation decontamination agents Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d79c295debdd426b986d1f0db51869ab
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spelling	oai:doaj.org-article:d79c295debdd426b986d1f0db51869ab2021-12-02T07:56:32ZSafe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide1178-2013https://doaj.org/article/d79c295debdd426b986d1f0db51869ab2018-11-01T00:00:00Zhttps://www.dovepress.com/safe-decontamination-of-cytostatics-from-the-nitrogen-mustards-family--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Irena R &Scaron;tenglová Netíková,1 Lubo&scaron; Petruželka,2,3 Martin &Scaron;tastný,1,2 Václav &Scaron;tengl1 1Department of Oncology, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic; 2Department of Material Chemistry, Institute of Inorganic Chemistry ASCR v.v.i., Rež, Czech Republic; 3Faculty of Environment, J.E. Purkyne University in Ústí nad Labem, Ústí nad labem, Czech Republic Introduction: Macrocrystalline oxides of alkaline earth metals (Mg and Ca) or light metals (Al and Ti) can respond to standard warfare agents such as sulfur mustard, soman, or agent VX. In this paper, we compared the decontamination ability of sodium hydroxide (NaOH) and sodium hypochlorite (NaClO) for nitrogen mustards (cyclophosphamide [CP] and ifosfamide [IFOS]) with a new procedure using a destructive sorbent based on nanocrystalline and nanodispersive titanium dioxide (TiO2) as a new efficient and cheap material for complete decontamination of surfaces.Methods: Titanium (IV) dioxide nanoparticles were prepared by the homogeneous hydrolysis of titanium(IV) oxysulfate (TiOSO4) with urea. The as-prepared TiO2 nanoparticles were used for the fast and safe decontamination of cytostatics from the nitrogen mustard family (CP and IFOS) in water. The adsorption–degradation process of cytostatics in the presence of TiO2 was compared with decontamination agents (0.01 M solution of sodium hydroxide and 5% solution of sodium hypochlorite). The mechanism of the decontamination process and the degradation efficiency were determined by high-performance liquid chromatography with mass spectrometry.Results: It was demonstrated that a 0.01 M solution of sodium hydroxide (NaOH) decomposes CP to 3-((amino(bis(2-chloroethyl)amino)phosphoryl)oxy)propanoic acid and sodium hypochlorite formed two reaction products, namely, IFOS and 4-hydroxy-cyclophosphamide. IFOS is cytotoxic, and 4-hydroxy-cyclophosphamide is a known metabolite of CP after its partial metabolism by CYP/CYP450. IFOS degrades in the pres¬ence of NaOH to toxic IFOS mustard. Titanium(IV) dioxide nanoparticles adsorbed on its surface CP after 5 minutes and on IFOS after 10 minutes. The adsorption–degradation process of CP in water and in the presence of TiO2 led to 4-hydroxy-cyclophosphamide and IFOS, respectively, which decayed to oxidation product 4-hydroxy-ifosfamide.Conclusion: Nanodispersive TiO2 is an effective degradation agent for decontamination of surfaces from cytostatics in medical facilities. Keywords: cyclophosphamide, ifosfamide, ifosfamide mustard, titanium(IV) dioxide, degradation, decontamination agentsŠtenglová Netíková IRPetruželka LŠťastný MŠtengl VDove Medical Pressarticlecyclophosphamideifosfamideifosfamide mustardtitanium(IV) dioxidedegradationdecontamination agentsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 7971-7985 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	cyclophosphamide ifosfamide ifosfamide mustard titanium(IV) dioxide degradation decontamination agents Medicine (General) R5-920
spellingShingle	cyclophosphamide ifosfamide ifosfamide mustard titanium(IV) dioxide degradation decontamination agents Medicine (General) R5-920 Štenglová Netíková IR Petruželka L Šťastný M Štengl V Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide
description	Irena R &Scaron;tenglová Netíková,1 Lubo&scaron; Petruželka,2,3 Martin &Scaron;tastný,1,2 Václav &Scaron;tengl1 1Department of Oncology, 1st Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic; 2Department of Material Chemistry, Institute of Inorganic Chemistry ASCR v.v.i., Rež, Czech Republic; 3Faculty of Environment, J.E. Purkyne University in Ústí nad Labem, Ústí nad labem, Czech Republic Introduction: Macrocrystalline oxides of alkaline earth metals (Mg and Ca) or light metals (Al and Ti) can respond to standard warfare agents such as sulfur mustard, soman, or agent VX. In this paper, we compared the decontamination ability of sodium hydroxide (NaOH) and sodium hypochlorite (NaClO) for nitrogen mustards (cyclophosphamide [CP] and ifosfamide [IFOS]) with a new procedure using a destructive sorbent based on nanocrystalline and nanodispersive titanium dioxide (TiO2) as a new efficient and cheap material for complete decontamination of surfaces.Methods: Titanium (IV) dioxide nanoparticles were prepared by the homogeneous hydrolysis of titanium(IV) oxysulfate (TiOSO4) with urea. The as-prepared TiO2 nanoparticles were used for the fast and safe decontamination of cytostatics from the nitrogen mustard family (CP and IFOS) in water. The adsorption–degradation process of cytostatics in the presence of TiO2 was compared with decontamination agents (0.01 M solution of sodium hydroxide and 5% solution of sodium hypochlorite). The mechanism of the decontamination process and the degradation efficiency were determined by high-performance liquid chromatography with mass spectrometry.Results: It was demonstrated that a 0.01 M solution of sodium hydroxide (NaOH) decomposes CP to 3-((amino(bis(2-chloroethyl)amino)phosphoryl)oxy)propanoic acid and sodium hypochlorite formed two reaction products, namely, IFOS and 4-hydroxy-cyclophosphamide. IFOS is cytotoxic, and 4-hydroxy-cyclophosphamide is a known metabolite of CP after its partial metabolism by CYP/CYP450. IFOS degrades in the pres¬ence of NaOH to toxic IFOS mustard. Titanium(IV) dioxide nanoparticles adsorbed on its surface CP after 5 minutes and on IFOS after 10 minutes. The adsorption–degradation process of CP in water and in the presence of TiO2 led to 4-hydroxy-cyclophosphamide and IFOS, respectively, which decayed to oxidation product 4-hydroxy-ifosfamide.Conclusion: Nanodispersive TiO2 is an effective degradation agent for decontamination of surfaces from cytostatics in medical facilities. Keywords: cyclophosphamide, ifosfamide, ifosfamide mustard, titanium(IV) dioxide, degradation, decontamination agents
format	article
author	Štenglová Netíková IR Petruželka L Šťastný M Štengl V
author_facet	Štenglová Netíková IR Petruželka L Šťastný M Štengl V
author_sort	Štenglová Netíková IR
title	Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide
title_short	Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide
title_full	Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide
title_fullStr	Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide
title_full_unstemmed	Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide
title_sort	safe decontamination of cytostatics from the nitrogen mustards family. part one: cyclophosphamide and ifosfamide
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d79c295debdd426b986d1f0db51869ab
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Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide

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