Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse.

Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse.

The integrity of male germ cell genome is critical for the correct progression of spermatogenesis, successful fertilization, and proper development of the offspring. Several DNA repair pathways exist in male germ cells. However, unlike somatic cells, key components of such pathways remain largely un...

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Auteurs principaux: Duangporn Jamsai, Anne E O'Connor, Kathleen D Deboer, Brett J Clark, Stephanie J Smith, Catherine M Browne, Jonathan G Bensley, Julie A Merriman, Wai Shan Yuen, Peter Koopman, Keith T Jones, Moira K O'Bryan
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2013
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/d7a0f0a865394e3486e2c03857a7f8d2
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