Evolutionary divergence of novel open reading frames in cichlids speciation

Abstract Novel open reading frames (nORFs) with coding potential may arise from noncoding DNA. Not much is known about their emergence, functional role, fixation in a population or contribution to adaptive radiation. Cichlids fishes exhibit extensive phenotypic diversification and speciation. Encoun...

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Autores principales:	Shraddha Puntambekar, Rachel Newhouse, Jaime San Miguel Navas, Ruchi Chauhan, Grégoire Vernaz, Thomas Willis, Matthew T. Wayland, Yagnesh Umrania, Eric A. Miska, Sudhakaran Prabakaran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d7a75993196c48729509b1ea6dea1a13
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spelling	oai:doaj.org-article:d7a75993196c48729509b1ea6dea1a132021-12-02T15:11:49ZEvolutionary divergence of novel open reading frames in cichlids speciation10.1038/s41598-020-78555-02045-2322https://doaj.org/article/d7a75993196c48729509b1ea6dea1a132020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78555-0https://doaj.org/toc/2045-2322Abstract Novel open reading frames (nORFs) with coding potential may arise from noncoding DNA. Not much is known about their emergence, functional role, fixation in a population or contribution to adaptive radiation. Cichlids fishes exhibit extensive phenotypic diversification and speciation. Encounters with new environments alone are not sufficient to explain this striking diversity of cichlid radiation because other taxa coexistent with the Cichlidae demonstrate lower species richness. Wagner et al. analyzed cichlid diversification in 46 African lakes and reported that both extrinsic environmental factors and intrinsic lineage-specific traits related to sexual selection have strongly influenced the cichlid radiation, which indicates the existence of unknown molecular mechanisms responsible for rapid phenotypic diversification, such as emergence of novel open reading frames (nORFs). In this study, we integrated transcriptomic and proteomic signatures from two tissues of two cichlids species, identified nORFs and performed evolutionary analysis on these nORF regions. Our results suggest that the time scale of speciation of the two species and evolutionary divergence of these nORF genomic regions are similar and indicate a potential role for these nORFs in speciation of the cichlid fishes.Shraddha PuntambekarRachel NewhouseJaime San Miguel NavasRuchi ChauhanGrégoire VernazThomas WillisMatthew T. WaylandYagnesh UmraniaEric A. MiskaSudhakaran PrabakaranNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shraddha Puntambekar Rachel Newhouse Jaime San Miguel Navas Ruchi Chauhan Grégoire Vernaz Thomas Willis Matthew T. Wayland Yagnesh Umrania Eric A. Miska Sudhakaran Prabakaran Evolutionary divergence of novel open reading frames in cichlids speciation
description	Abstract Novel open reading frames (nORFs) with coding potential may arise from noncoding DNA. Not much is known about their emergence, functional role, fixation in a population or contribution to adaptive radiation. Cichlids fishes exhibit extensive phenotypic diversification and speciation. Encounters with new environments alone are not sufficient to explain this striking diversity of cichlid radiation because other taxa coexistent with the Cichlidae demonstrate lower species richness. Wagner et al. analyzed cichlid diversification in 46 African lakes and reported that both extrinsic environmental factors and intrinsic lineage-specific traits related to sexual selection have strongly influenced the cichlid radiation, which indicates the existence of unknown molecular mechanisms responsible for rapid phenotypic diversification, such as emergence of novel open reading frames (nORFs). In this study, we integrated transcriptomic and proteomic signatures from two tissues of two cichlids species, identified nORFs and performed evolutionary analysis on these nORF regions. Our results suggest that the time scale of speciation of the two species and evolutionary divergence of these nORF genomic regions are similar and indicate a potential role for these nORFs in speciation of the cichlid fishes.
format	article
author	Shraddha Puntambekar Rachel Newhouse Jaime San Miguel Navas Ruchi Chauhan Grégoire Vernaz Thomas Willis Matthew T. Wayland Yagnesh Umrania Eric A. Miska Sudhakaran Prabakaran
author_facet	Shraddha Puntambekar Rachel Newhouse Jaime San Miguel Navas Ruchi Chauhan Grégoire Vernaz Thomas Willis Matthew T. Wayland Yagnesh Umrania Eric A. Miska Sudhakaran Prabakaran
author_sort	Shraddha Puntambekar
title	Evolutionary divergence of novel open reading frames in cichlids speciation
title_short	Evolutionary divergence of novel open reading frames in cichlids speciation
title_full	Evolutionary divergence of novel open reading frames in cichlids speciation
title_fullStr	Evolutionary divergence of novel open reading frames in cichlids speciation
title_full_unstemmed	Evolutionary divergence of novel open reading frames in cichlids speciation
title_sort	evolutionary divergence of novel open reading frames in cichlids speciation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d7a75993196c48729509b1ea6dea1a13
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Evolutionary divergence of novel open reading frames in cichlids speciation

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