In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release

Rotaviruses are of great medical significance because they cause gastroenteritis in children. Here the authors provide insights into the mechanism of viral mRNA transcription by determining the in situ cryo-EM structures of a working rotavirus’ RNA-dependent-RNA polymerase, which is of interest for...

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Autores principales:	Ke Ding, Cristina C. Celma, Xing Zhang, Thomas Chang, Wesley Shen, Ivo Atanasov, Polly Roy, Z. Hong Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d7ab0cfbd1d642369d08a8a85f7cd652
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spelling	oai:doaj.org-article:d7ab0cfbd1d642369d08a8a85f7cd6522021-12-02T17:01:37ZIn situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release10.1038/s41467-019-10236-72041-1723https://doaj.org/article/d7ab0cfbd1d642369d08a8a85f7cd6522019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10236-7https://doaj.org/toc/2041-1723Rotaviruses are of great medical significance because they cause gastroenteritis in children. Here the authors provide insights into the mechanism of viral mRNA transcription by determining the in situ cryo-EM structures of a working rotavirus’ RNA-dependent-RNA polymerase, which is of interest for antiviral drug design.Ke DingCristina C. CelmaXing ZhangThomas ChangWesley ShenIvo AtanasovPolly RoyZ. Hong ZhouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ke Ding Cristina C. Celma Xing Zhang Thomas Chang Wesley Shen Ivo Atanasov Polly Roy Z. Hong Zhou In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release
description	Rotaviruses are of great medical significance because they cause gastroenteritis in children. Here the authors provide insights into the mechanism of viral mRNA transcription by determining the in situ cryo-EM structures of a working rotavirus’ RNA-dependent-RNA polymerase, which is of interest for antiviral drug design.
format	article
author	Ke Ding Cristina C. Celma Xing Zhang Thomas Chang Wesley Shen Ivo Atanasov Polly Roy Z. Hong Zhou
author_facet	Ke Ding Cristina C. Celma Xing Zhang Thomas Chang Wesley Shen Ivo Atanasov Polly Roy Z. Hong Zhou
author_sort	Ke Ding
title	In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release
title_short	In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release
title_full	In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release
title_fullStr	In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release
title_full_unstemmed	In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release
title_sort	in situ structures of rotavirus polymerase in action and mechanism of mrna transcription and release
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d7ab0cfbd1d642369d08a8a85f7cd652
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In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release

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