In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release
Rotaviruses are of great medical significance because they cause gastroenteritis in children. Here the authors provide insights into the mechanism of viral mRNA transcription by determining the in situ cryo-EM structures of a working rotavirus’ RNA-dependent-RNA polymerase, which is of interest for...
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Nature Portfolio
2019
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oai:doaj.org-article:d7ab0cfbd1d642369d08a8a85f7cd6522021-12-02T17:01:37ZIn situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release10.1038/s41467-019-10236-72041-1723https://doaj.org/article/d7ab0cfbd1d642369d08a8a85f7cd6522019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10236-7https://doaj.org/toc/2041-1723Rotaviruses are of great medical significance because they cause gastroenteritis in children. Here the authors provide insights into the mechanism of viral mRNA transcription by determining the in situ cryo-EM structures of a working rotavirus’ RNA-dependent-RNA polymerase, which is of interest for antiviral drug design.Ke DingCristina C. CelmaXing ZhangThomas ChangWesley ShenIvo AtanasovPolly RoyZ. Hong ZhouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019) |
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Science Q Ke Ding Cristina C. Celma Xing Zhang Thomas Chang Wesley Shen Ivo Atanasov Polly Roy Z. Hong Zhou In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release |
description |
Rotaviruses are of great medical significance because they cause gastroenteritis in children. Here the authors provide insights into the mechanism of viral mRNA transcription by determining the in situ cryo-EM structures of a working rotavirus’ RNA-dependent-RNA polymerase, which is of interest for antiviral drug design. |
format |
article |
author |
Ke Ding Cristina C. Celma Xing Zhang Thomas Chang Wesley Shen Ivo Atanasov Polly Roy Z. Hong Zhou |
author_facet |
Ke Ding Cristina C. Celma Xing Zhang Thomas Chang Wesley Shen Ivo Atanasov Polly Roy Z. Hong Zhou |
author_sort |
Ke Ding |
title |
In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release |
title_short |
In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release |
title_full |
In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release |
title_fullStr |
In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release |
title_full_unstemmed |
In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release |
title_sort |
in situ structures of rotavirus polymerase in action and mechanism of mrna transcription and release |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/d7ab0cfbd1d642369d08a8a85f7cd652 |
work_keys_str_mv |
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