Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster

The 16p11.2 deletion leads to a range of neurodevelopmental phenotypes, but to date, sequencing studies have not been able to pinpoint individual genes that are causative for the disease on their own. Here, using Drosophila homologs of 14 16p11.2 genes, the authors take a combinatorial approach to s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Janani Iyer, Mayanglambam Dhruba Singh, Matthew Jensen, Payal Patel, Lucilla Pizzo, Emily Huber, Haley Koerselman, Alexis T. Weiner, Paola Lepanto, Komal Vadodaria, Alexis Kubina, Qingyu Wang, Abigail Talbert, Sneha Yennawar, Jose Badano, J. Robert Manak, Melissa M. Rolls, Arjun Krishnan, Santhosh Girirajan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d7ac17fe1f8f4fac96fe435cdcaaa18c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d7ac17fe1f8f4fac96fe435cdcaaa18c
record_format	dspace
spelling	oai:doaj.org-article:d7ac17fe1f8f4fac96fe435cdcaaa18c2021-12-02T15:34:08ZPervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster10.1038/s41467-018-04882-62041-1723https://doaj.org/article/d7ac17fe1f8f4fac96fe435cdcaaa18c2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04882-6https://doaj.org/toc/2041-1723The 16p11.2 deletion leads to a range of neurodevelopmental phenotypes, but to date, sequencing studies have not been able to pinpoint individual genes that are causative for the disease on their own. Here, using Drosophila homologs of 14 16p11.2 genes, the authors take a combinatorial approach to show that gene interactions contribute to a neurological phenotype.Janani IyerMayanglambam Dhruba SinghMatthew JensenPayal PatelLucilla PizzoEmily HuberHaley KoerselmanAlexis T. WeinerPaola LepantoKomal VadodariaAlexis KubinaQingyu WangAbigail TalbertSneha YennawarJose BadanoJ. Robert ManakMelissa M. RollsArjun KrishnanSanthosh GirirajanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Janani Iyer Mayanglambam Dhruba Singh Matthew Jensen Payal Patel Lucilla Pizzo Emily Huber Haley Koerselman Alexis T. Weiner Paola Lepanto Komal Vadodaria Alexis Kubina Qingyu Wang Abigail Talbert Sneha Yennawar Jose Badano J. Robert Manak Melissa M. Rolls Arjun Krishnan Santhosh Girirajan Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster
description	The 16p11.2 deletion leads to a range of neurodevelopmental phenotypes, but to date, sequencing studies have not been able to pinpoint individual genes that are causative for the disease on their own. Here, using Drosophila homologs of 14 16p11.2 genes, the authors take a combinatorial approach to show that gene interactions contribute to a neurological phenotype.
format	article
author	Janani Iyer Mayanglambam Dhruba Singh Matthew Jensen Payal Patel Lucilla Pizzo Emily Huber Haley Koerselman Alexis T. Weiner Paola Lepanto Komal Vadodaria Alexis Kubina Qingyu Wang Abigail Talbert Sneha Yennawar Jose Badano J. Robert Manak Melissa M. Rolls Arjun Krishnan Santhosh Girirajan
author_facet	Janani Iyer Mayanglambam Dhruba Singh Matthew Jensen Payal Patel Lucilla Pizzo Emily Huber Haley Koerselman Alexis T. Weiner Paola Lepanto Komal Vadodaria Alexis Kubina Qingyu Wang Abigail Talbert Sneha Yennawar Jose Badano J. Robert Manak Melissa M. Rolls Arjun Krishnan Santhosh Girirajan
author_sort	Janani Iyer
title	Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster
title_short	Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster
title_full	Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster
title_fullStr	Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster
title_full_unstemmed	Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster
title_sort	pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in drosophila melanogaster
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d7ac17fe1f8f4fac96fe435cdcaaa18c
work_keys_str_mv	AT jananiiyer pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT mayanglambamdhrubasingh pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT matthewjensen pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT payalpatel pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT lucillapizzo pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT emilyhuber pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT haleykoerselman pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT alexistweiner pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT paolalepanto pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT komalvadodaria pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT alexiskubina pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT qingyuwang pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT abigailtalbert pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT snehayennawar pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT josebadano pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT jrobertmanak pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT melissamrolls pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT arjunkrishnan pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster AT santhoshgirirajan pervasivegeneticinteractionsmodulateneurodevelopmentaldefectsoftheautismassociated16p112deletionindrosophilamelanogaster
_version_	1718386931563233280

Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster

Ejemplares similares