Nontoxic hydrophilic polymeric nanocomposites containing silver nanoparticles with strong antimicrobial activity

Alexander S Pozdnyakov,1 Artem I Emel’yanov,1 Nadezhda P Kuznetsova,1 Tamara G Ermakova,1 Tat’yana V Fadeeva,2 Larisa M Sosedova,3 Galina F Prozorova11AE Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 2Federal State Budgetary Scientific Ins...

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Autores principales:	Pozdnyakov AS, Emel’yanov AI, Kuznetsova NP, Ermakova TG, Fadeeva TV, Sosedova LM, Prozorova GF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	nontoxic nanocomposites antimicrobial activity silver nanoparticles 1-vinyl-1 2 4-triazole N-vinylpyrrolidone Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d7b0e9771e404031b71877c4bc888f00
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spelling	oai:doaj.org-article:d7b0e9771e404031b71877c4bc888f002021-12-02T02:42:29ZNontoxic hydrophilic polymeric nanocomposites containing silver nanoparticles with strong antimicrobial activity1178-2013https://doaj.org/article/d7b0e9771e404031b71877c4bc888f002016-03-01T00:00:00Zhttps://www.dovepress.com/nontoxic-hydrophilic-polymeric-nanocomposites-containing-silver-nanopa-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Alexander S Pozdnyakov,1 Artem I Emel’yanov,1 Nadezhda P Kuznetsova,1 Tamara G Ermakova,1 Tat’yana V Fadeeva,2 Larisa M Sosedova,3 Galina F Prozorova11AE Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 2Federal State Budgetary Scientific Institution Irkutsk Scientific Center of Surgery and Traumatology, Laboratory of Functional Genomics and Interspecific Interactions of Microorganisms, Irkutsk, 3East-Siberian Institute of Medical & Ecological Science, Department of Biomodeling & Translational Investigation, Angarsk, RussiaAbstract: New nontoxic hydrophilic nanocomposites containing metallic silver nanoparticles (AgNPs) in a polymer matrix were synthesized by the chemical reduction of silver ions in an aqueous medium. A new nontoxic water soluble copolymer of 1-vinyl-1,2,4-triazole and N-vinylpyrrolidone synthesized by free radical-initiated polymerization was used as a stabilizing agent. Transmission electron microscopy, scanning electron microscopy, ultraviolet–visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, atomic absorption, and thermogravimetric analysis were used to characterize polymeric AgNPs nanocomposites. The results showed that the diameter of the synthesized AgNPs ranged from 2 to 6 nm. The toxicity of the initial copolymer of 1-vinyl-1,2,4-triazole and N-vinylpyrrolidone and its nanocomposite with AgNPs was found to be more than 5,000 mg/kg. The synthesized AgNP polymeric nanocomposite showed significant antimicrobial activity against different strains of Gram-negative and -positive bacteria. The minimum inhibitory concentrations suppressing the growth of the microorganisms ranged from 0.5 to 8 µg/mL and the minimum bactericidal concentrations ranged from 0.5 to 16 µg/mL. The fabricated AgNP nanocomposites are promising materials for the design of novel nontoxic hydrophilic antiseptics and antimicrobial components for medical purposes.Keywords: nontoxic nanocomposites, antimicrobial activity, silver nanoparticles, 1-vinyl-1,2,4-triazole, N-vinylpyrrolidonePozdnyakov ASEmel’yanov AIKuznetsova NPErmakova TGFadeeva TVSosedova LMProzorova GFDove Medical Pressarticlenontoxic nanocompositesantimicrobial activitysilver nanoparticles1-vinyl-124-triazoleN-vinylpyrrolidoneMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1295-1304 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	nontoxic nanocomposites antimicrobial activity silver nanoparticles 1-vinyl-1 2 4-triazole N-vinylpyrrolidone Medicine (General) R5-920
spellingShingle	nontoxic nanocomposites antimicrobial activity silver nanoparticles 1-vinyl-1 2 4-triazole N-vinylpyrrolidone Medicine (General) R5-920 Pozdnyakov AS Emel’yanov AI Kuznetsova NP Ermakova TG Fadeeva TV Sosedova LM Prozorova GF Nontoxic hydrophilic polymeric nanocomposites containing silver nanoparticles with strong antimicrobial activity
description	Alexander S Pozdnyakov,1 Artem I Emel’yanov,1 Nadezhda P Kuznetsova,1 Tamara G Ermakova,1 Tat’yana V Fadeeva,2 Larisa M Sosedova,3 Galina F Prozorova11AE Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 2Federal State Budgetary Scientific Institution Irkutsk Scientific Center of Surgery and Traumatology, Laboratory of Functional Genomics and Interspecific Interactions of Microorganisms, Irkutsk, 3East-Siberian Institute of Medical & Ecological Science, Department of Biomodeling & Translational Investigation, Angarsk, RussiaAbstract: New nontoxic hydrophilic nanocomposites containing metallic silver nanoparticles (AgNPs) in a polymer matrix were synthesized by the chemical reduction of silver ions in an aqueous medium. A new nontoxic water soluble copolymer of 1-vinyl-1,2,4-triazole and N-vinylpyrrolidone synthesized by free radical-initiated polymerization was used as a stabilizing agent. Transmission electron microscopy, scanning electron microscopy, ultraviolet–visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, atomic absorption, and thermogravimetric analysis were used to characterize polymeric AgNPs nanocomposites. The results showed that the diameter of the synthesized AgNPs ranged from 2 to 6 nm. The toxicity of the initial copolymer of 1-vinyl-1,2,4-triazole and N-vinylpyrrolidone and its nanocomposite with AgNPs was found to be more than 5,000 mg/kg. The synthesized AgNP polymeric nanocomposite showed significant antimicrobial activity against different strains of Gram-negative and -positive bacteria. The minimum inhibitory concentrations suppressing the growth of the microorganisms ranged from 0.5 to 8 µg/mL and the minimum bactericidal concentrations ranged from 0.5 to 16 µg/mL. The fabricated AgNP nanocomposites are promising materials for the design of novel nontoxic hydrophilic antiseptics and antimicrobial components for medical purposes.Keywords: nontoxic nanocomposites, antimicrobial activity, silver nanoparticles, 1-vinyl-1,2,4-triazole, N-vinylpyrrolidone
format	article
author	Pozdnyakov AS Emel’yanov AI Kuznetsova NP Ermakova TG Fadeeva TV Sosedova LM Prozorova GF
author_facet	Pozdnyakov AS Emel’yanov AI Kuznetsova NP Ermakova TG Fadeeva TV Sosedova LM Prozorova GF
author_sort	Pozdnyakov AS
title	Nontoxic hydrophilic polymeric nanocomposites containing silver nanoparticles with strong antimicrobial activity
title_short	Nontoxic hydrophilic polymeric nanocomposites containing silver nanoparticles with strong antimicrobial activity
title_full	Nontoxic hydrophilic polymeric nanocomposites containing silver nanoparticles with strong antimicrobial activity
title_fullStr	Nontoxic hydrophilic polymeric nanocomposites containing silver nanoparticles with strong antimicrobial activity
title_full_unstemmed	Nontoxic hydrophilic polymeric nanocomposites containing silver nanoparticles with strong antimicrobial activity
title_sort	nontoxic hydrophilic polymeric nanocomposites containing silver nanoparticles with strong antimicrobial activity
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/d7b0e9771e404031b71877c4bc888f00
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Nontoxic hydrophilic polymeric nanocomposites containing silver nanoparticles with strong antimicrobial activity

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