Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs

The precise relationship between neurobehavioural effects and neurotransmitter effects of psychiatric drugs are not always understood. Here the authors develop a database documenting the neurotransmitter response in rats to 258 different neuropsychiatric drugs, and conclude that this neurotransmitte...

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Autores principales: Hamid R. Noori, Lewis H. Mervin, Vahid Bokharaie, Özlem Durmus, Lisamon Egenrieder, Stefan Fritze, Britta Gruhlke, Giulia Reinhardt, Hans-Hendrik Schabel, Sabine Staudenmaier, Nikos K. Logothetis, Andreas Bender, Rainer Spanagel
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d7b1a3592d6d4e2087b019333a9fb4e3
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spelling oai:doaj.org-article:d7b1a3592d6d4e2087b019333a9fb4e32021-12-02T14:40:31ZSystemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs10.1038/s41467-018-07239-12041-1723https://doaj.org/article/d7b1a3592d6d4e2087b019333a9fb4e32018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07239-1https://doaj.org/toc/2041-1723The precise relationship between neurobehavioural effects and neurotransmitter effects of psychiatric drugs are not always understood. Here the authors develop a database documenting the neurotransmitter response in rats to 258 different neuropsychiatric drugs, and conclude that this neurotransmitter response does not, in general, reflect the current categorisation of those drugs.Hamid R. NooriLewis H. MervinVahid BokharaieÖzlem DurmusLisamon EgenriederStefan FritzeBritta GruhlkeGiulia ReinhardtHans-Hendrik SchabelSabine StaudenmaierNikos K. LogothetisAndreas BenderRainer SpanagelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hamid R. Noori
Lewis H. Mervin
Vahid Bokharaie
Özlem Durmus
Lisamon Egenrieder
Stefan Fritze
Britta Gruhlke
Giulia Reinhardt
Hans-Hendrik Schabel
Sabine Staudenmaier
Nikos K. Logothetis
Andreas Bender
Rainer Spanagel
Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
description The precise relationship between neurobehavioural effects and neurotransmitter effects of psychiatric drugs are not always understood. Here the authors develop a database documenting the neurotransmitter response in rats to 258 different neuropsychiatric drugs, and conclude that this neurotransmitter response does not, in general, reflect the current categorisation of those drugs.
format article
author Hamid R. Noori
Lewis H. Mervin
Vahid Bokharaie
Özlem Durmus
Lisamon Egenrieder
Stefan Fritze
Britta Gruhlke
Giulia Reinhardt
Hans-Hendrik Schabel
Sabine Staudenmaier
Nikos K. Logothetis
Andreas Bender
Rainer Spanagel
author_facet Hamid R. Noori
Lewis H. Mervin
Vahid Bokharaie
Özlem Durmus
Lisamon Egenrieder
Stefan Fritze
Britta Gruhlke
Giulia Reinhardt
Hans-Hendrik Schabel
Sabine Staudenmaier
Nikos K. Logothetis
Andreas Bender
Rainer Spanagel
author_sort Hamid R. Noori
title Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
title_short Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
title_full Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
title_fullStr Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
title_full_unstemmed Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
title_sort systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/d7b1a3592d6d4e2087b019333a9fb4e3
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