Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis
Abstract This study aimed to assess the association of coagulation-related indicators such as plasma fibrinogen (FIB), d-dimer, and fibrin degradation product (FDP) in rheumatoid arthritis (RA) with the disease activity. Data from 105 RA patients and 102 age- and gender-matched healthy controls were...
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Nature Portfolio
2021
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oai:doaj.org-article:d7b294375cde489996c1c98519bf622e2021-12-02T17:08:36ZPlasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis10.1038/s41598-021-96349-w2045-2322https://doaj.org/article/d7b294375cde489996c1c98519bf622e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96349-whttps://doaj.org/toc/2045-2322Abstract This study aimed to assess the association of coagulation-related indicators such as plasma fibrinogen (FIB), d-dimer, and fibrin degradation product (FDP) in rheumatoid arthritis (RA) with the disease activity. Data from 105 RA patients and 102 age- and gender-matched healthy controls were collected in the retrospective study. Disease activity score in 28 joints based on C-reactive protein (DAS28-CRP) was used to divide RA patients into low activity group (DAS28-CRP ≤ 2.7) and active group (DAS28-CRP > 2.7). Receiver operating characteristic (ROC) curve was applied to determine area under the curve (AUC). The association between plasma FIB, d-dimer, and FDP and DAS28-CRP was evaluated by spearman correlation. Logistical regression analysis was used to identify the independent variables associated with RA disease activity. RA patients showed higher levels of plasma FIB, d-dimer, and FDP than the controls (P < 0.01). Plasma FIB, d-dimer, and FDP were also increased in active groups of RA patients than those in inactive groups (P < 0.001). ROC curve analyses revealed that the AUC of d-dimer was higher than erythrocyte sedimentation rate (ESR) and rheumatoid factor (RF), and that of FDP was higher than RF in RA patients. In addition, the optimal cut-off value of plasma FIB, d-dimer, and FDP for RA diagnosis was 286 mg/dL, 470 μg/L, and 1.45 mg/L, respectively. Spearman analysis showed that plasma FIB, d-dimer, and FDP were positively related with DAS28-CRP (P < 0.001) in RA patients. Logistical regression analysis showed that d-dimer (odds ratio 2.862, 95% confidence interval 1.851–5.426, P < 0.001) was an independent variable associated with RA disease activity. FIB, d-dimer, and FDP were increased in RA patients and positively correlated with the disease activity of RA. d-dimer may act as a novel inflammatory indice for indicating disease activity in RA patients.Li XueLi TaoXueyi LiYan WangBiao WangYanping ZhangNing GaoYanying DongNan XuChaoliang XiongTing ZhouZeshi LiuHailong LiuJuntao HeKe LiYan GengMing LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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Medicine R Science Q Li Xue Li Tao Xueyi Li Yan Wang Biao Wang Yanping Zhang Ning Gao Yanying Dong Nan Xu Chaoliang Xiong Ting Zhou Zeshi Liu Hailong Liu Juntao He Ke Li Yan Geng Ming Li Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis |
| description |
Abstract This study aimed to assess the association of coagulation-related indicators such as plasma fibrinogen (FIB), d-dimer, and fibrin degradation product (FDP) in rheumatoid arthritis (RA) with the disease activity. Data from 105 RA patients and 102 age- and gender-matched healthy controls were collected in the retrospective study. Disease activity score in 28 joints based on C-reactive protein (DAS28-CRP) was used to divide RA patients into low activity group (DAS28-CRP ≤ 2.7) and active group (DAS28-CRP > 2.7). Receiver operating characteristic (ROC) curve was applied to determine area under the curve (AUC). The association between plasma FIB, d-dimer, and FDP and DAS28-CRP was evaluated by spearman correlation. Logistical regression analysis was used to identify the independent variables associated with RA disease activity. RA patients showed higher levels of plasma FIB, d-dimer, and FDP than the controls (P < 0.01). Plasma FIB, d-dimer, and FDP were also increased in active groups of RA patients than those in inactive groups (P < 0.001). ROC curve analyses revealed that the AUC of d-dimer was higher than erythrocyte sedimentation rate (ESR) and rheumatoid factor (RF), and that of FDP was higher than RF in RA patients. In addition, the optimal cut-off value of plasma FIB, d-dimer, and FDP for RA diagnosis was 286 mg/dL, 470 μg/L, and 1.45 mg/L, respectively. Spearman analysis showed that plasma FIB, d-dimer, and FDP were positively related with DAS28-CRP (P < 0.001) in RA patients. Logistical regression analysis showed that d-dimer (odds ratio 2.862, 95% confidence interval 1.851–5.426, P < 0.001) was an independent variable associated with RA disease activity. FIB, d-dimer, and FDP were increased in RA patients and positively correlated with the disease activity of RA. d-dimer may act as a novel inflammatory indice for indicating disease activity in RA patients. |
| format |
article |
| author |
Li Xue Li Tao Xueyi Li Yan Wang Biao Wang Yanping Zhang Ning Gao Yanying Dong Nan Xu Chaoliang Xiong Ting Zhou Zeshi Liu Hailong Liu Juntao He Ke Li Yan Geng Ming Li |
| author_facet |
Li Xue Li Tao Xueyi Li Yan Wang Biao Wang Yanping Zhang Ning Gao Yanying Dong Nan Xu Chaoliang Xiong Ting Zhou Zeshi Liu Hailong Liu Juntao He Ke Li Yan Geng Ming Li |
| author_sort |
Li Xue |
| title |
Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis |
| title_short |
Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis |
| title_full |
Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis |
| title_fullStr |
Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis |
| title_full_unstemmed |
Plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis |
| title_sort |
plasma fibrinogen, d-dimer, and fibrin degradation product as biomarkers of rheumatoid arthritis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d7b294375cde489996c1c98519bf622e |
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