Associations between CRYBA4 gene variants and high myopia in a Japanese population

Tatsukata Kawagoe,1 Masao Ota,1,2 Akira Meguro,1 Masaki Takeuchi,1 Takahiro Yamane,1 Haruna Shimazaki,3 Masaru Takeuchi,3 Eiichi Okada,4 Takeshi Teshigawara,1,5,6 Nobuhisa Mizuki1 1Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, 2Depar...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kawagoe T, Ota M, Meguro A, Takeuchi M, Yamane T, Shimazaki H, Okada E, Teshigawara T, Mizuki N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	high myopia CRYBA4 association study polymorphism Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d7b430249c4d435685fccee5324f47fb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d7b430249c4d435685fccee5324f47fb
record_format	dspace
spelling	oai:doaj.org-article:d7b430249c4d435685fccee5324f47fb2021-12-02T07:38:56ZAssociations between CRYBA4 gene variants and high myopia in a Japanese population1177-5483https://doaj.org/article/d7b430249c4d435685fccee5324f47fb2017-12-01T00:00:00Zhttps://www.dovepress.com/associations-between-cryba4-gene-variants-and-high-myopia-in-a-japanes-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Tatsukata Kawagoe,1 Masao Ota,1,2 Akira Meguro,1 Masaki Takeuchi,1 Takahiro Yamane,1 Haruna Shimazaki,3 Masaru Takeuchi,3 Eiichi Okada,4 Takeshi Teshigawara,1,5,6 Nobuhisa Mizuki1 1Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, 2Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, 3Department of Ophthalmology, National Defense Medical College, Tokorozawa, 4Okada Eye Clinic, Yokohama, 5Yokosuka Chuoh Eye Clinic, Yokosuka, 6Tsurumi Chuoh Eye Clinic, Yokohama, Japan Purpose: The crystallin beta A4 (CRYBA4) gene variant, rs2009066, was previously reported to be associated with high myopia in a southern Chinese population. In the present study, we investigated whether CRYBA4 variants were associated with high myopia in a Japanese population.Methods: We recruited 1,063 Japanese patients with high myopia (spherical equivalent [SE] ≤–9.00 D in both eyes) and 1,009 healthy Japanese subjects (SE >–1.00 D). We genotyped rs2009066 and three tagging single-nucleotide polymorphisms (SNPs), rs16982456, rs2071861, and rs4276, in the CRYBA4 region.Results: We did not find any significant association between these four SNPs and high myopia in an allele analysis. However, rs2009066 and rs2071861, which were in strong linkage disequilibrium (LD; r2=0.86), showed a marginal association with high myopia in the recessive genotype model of risk alleles (rs2009066 G allele: P=0.032, odds ratio [OR] =1.31; rs2071861 A allele: P=0.037, OR =1.31). Nevertheless, this association became insignificant after correcting for multiple testing (Pc >0.05).Conclusion: This study showed no significant association between CRYBA4 variants and high myopia in a Japanese population. Our findings did not correspond with a previous study. Further genetic studies with other populations are needed to elucidate a potential contribution of the CRYBA4 region in the development of high myopia. Keywords: high myopia, CRYBA4, association study, polymorphism Kawagoe TOta MMeguro ATakeuchi MYamane TShimazaki HTakeuchi MOkada ETeshigawara TMizuki NDove Medical Pressarticlehigh myopiaCRYBA4association studypolymorphismOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 2151-2156 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	high myopia CRYBA4 association study polymorphism Ophthalmology RE1-994
spellingShingle	high myopia CRYBA4 association study polymorphism Ophthalmology RE1-994 Kawagoe T Ota M Meguro A Takeuchi M Yamane T Shimazaki H Takeuchi M Okada E Teshigawara T Mizuki N Associations between CRYBA4 gene variants and high myopia in a Japanese population
description	Tatsukata Kawagoe,1 Masao Ota,1,2 Akira Meguro,1 Masaki Takeuchi,1 Takahiro Yamane,1 Haruna Shimazaki,3 Masaru Takeuchi,3 Eiichi Okada,4 Takeshi Teshigawara,1,5,6 Nobuhisa Mizuki1 1Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, 2Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, 3Department of Ophthalmology, National Defense Medical College, Tokorozawa, 4Okada Eye Clinic, Yokohama, 5Yokosuka Chuoh Eye Clinic, Yokosuka, 6Tsurumi Chuoh Eye Clinic, Yokohama, Japan Purpose: The crystallin beta A4 (CRYBA4) gene variant, rs2009066, was previously reported to be associated with high myopia in a southern Chinese population. In the present study, we investigated whether CRYBA4 variants were associated with high myopia in a Japanese population.Methods: We recruited 1,063 Japanese patients with high myopia (spherical equivalent [SE] ≤–9.00 D in both eyes) and 1,009 healthy Japanese subjects (SE >–1.00 D). We genotyped rs2009066 and three tagging single-nucleotide polymorphisms (SNPs), rs16982456, rs2071861, and rs4276, in the CRYBA4 region.Results: We did not find any significant association between these four SNPs and high myopia in an allele analysis. However, rs2009066 and rs2071861, which were in strong linkage disequilibrium (LD; r2=0.86), showed a marginal association with high myopia in the recessive genotype model of risk alleles (rs2009066 G allele: P=0.032, odds ratio [OR] =1.31; rs2071861 A allele: P=0.037, OR =1.31). Nevertheless, this association became insignificant after correcting for multiple testing (Pc >0.05).Conclusion: This study showed no significant association between CRYBA4 variants and high myopia in a Japanese population. Our findings did not correspond with a previous study. Further genetic studies with other populations are needed to elucidate a potential contribution of the CRYBA4 region in the development of high myopia. Keywords: high myopia, CRYBA4, association study, polymorphism
format	article
author	Kawagoe T Ota M Meguro A Takeuchi M Yamane T Shimazaki H Takeuchi M Okada E Teshigawara T Mizuki N
author_facet	Kawagoe T Ota M Meguro A Takeuchi M Yamane T Shimazaki H Takeuchi M Okada E Teshigawara T Mizuki N
author_sort	Kawagoe T
title	Associations between CRYBA4 gene variants and high myopia in a Japanese population
title_short	Associations between CRYBA4 gene variants and high myopia in a Japanese population
title_full	Associations between CRYBA4 gene variants and high myopia in a Japanese population
title_fullStr	Associations between CRYBA4 gene variants and high myopia in a Japanese population
title_full_unstemmed	Associations between CRYBA4 gene variants and high myopia in a Japanese population
title_sort	associations between cryba4 gene variants and high myopia in a japanese population
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/d7b430249c4d435685fccee5324f47fb
work_keys_str_mv	AT kawagoet associationsbetweencryba4genevariantsandhighmyopiainajapanesepopulation AT otam associationsbetweencryba4genevariantsandhighmyopiainajapanesepopulation AT meguroa associationsbetweencryba4genevariantsandhighmyopiainajapanesepopulation AT takeuchim associationsbetweencryba4genevariantsandhighmyopiainajapanesepopulation AT yamanet associationsbetweencryba4genevariantsandhighmyopiainajapanesepopulation AT shimazakih associationsbetweencryba4genevariantsandhighmyopiainajapanesepopulation AT takeuchim associationsbetweencryba4genevariantsandhighmyopiainajapanesepopulation AT okadae associationsbetweencryba4genevariantsandhighmyopiainajapanesepopulation AT teshigawarat associationsbetweencryba4genevariantsandhighmyopiainajapanesepopulation AT mizukin associationsbetweencryba4genevariantsandhighmyopiainajapanesepopulation
_version_	1718399308802293760

Associations between CRYBA4 gene variants and high myopia in a Japanese population

Ejemplares similares