Low Temperature Effect on the Endocrine and Circadian Systems of Adult Danio rerio

The control of the biological rhythms begins with the activation of photo- and thermosensitive cells located in various organs of the fish such as brain, eye, and skin, but a central clock is still to be identified in teleosts. Thermal changes are stressors which increase cortisol and affect the rhy...

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Autores principales:	Cristhian D. Sua-Cespedes, Daniela Dantas David, José A. Souto-Neto, Otoniel Gonçalves Lima, Maria Nathália Moraes, Leonardo V. Monteiro de Assis, Ana Maria de Lauro Castrucci
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Danio rerio temperature hormones clock genes hormone receptors Physiology QP1-981
Acceso en línea:	https://doaj.org/article/d7b5fec0a4e94b0a962d3f41cbfe5be8
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spelling	oai:doaj.org-article:d7b5fec0a4e94b0a962d3f41cbfe5be82021-11-30T17:55:52ZLow Temperature Effect on the Endocrine and Circadian Systems of Adult Danio rerio1664-042X10.3389/fphys.2021.707067https://doaj.org/article/d7b5fec0a4e94b0a962d3f41cbfe5be82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.707067/fullhttps://doaj.org/toc/1664-042XThe control of the biological rhythms begins with the activation of photo- and thermosensitive cells located in various organs of the fish such as brain, eye, and skin, but a central clock is still to be identified in teleosts. Thermal changes are stressors which increase cortisol and affect the rhythm of other hormones such as melatonin and growth hormone (GH), in both endo- and ectothermic organisms. Our aim was to investigate how temperature (23°C for 6 days) lower than the optimal (28°C) modulates expression of several gene pathways including growth hormone (gh1) and its receptors (ghra, ghrb), insulin-like growth factor1 (igf1a, igf1b) and its receptors (igf1ra, igf1rb), cortisol and its receptor (gr), the limiting enzyme of melatonin synthesis (arylalkylamine N-acetyltransferase, aanat) and melatonin receptors (mtnr1aa, mtnr1bb), as well as their relationship with clock genes in Danio rerio in early light and early dark phases of the day. Lower temperature reduced the expression of the hormone gene gh1, and of the related receptors ghra, ghrb, igf1ra, and igf1rb. Cortisol levels were higher at the lower temperature, with a decrease of its receptor (gr) transcripts in the liver. Interestingly, we found higher levels of aanat transcripts in the brain at 23°C. Overall, lower temperature downregulated the transcription of hormone related genes and clock genes. The results suggest a strong correlation of temperature challenge with the clock molecular mechanism and the endocrine systems analyzed, especially the growth hormone and melatonin axes, in D. rerio tissues.Cristhian D. Sua-CespedesDaniela Dantas DavidJosé A. Souto-NetoOtoniel Gonçalves LimaMaria Nathália MoraesLeonardo V. Monteiro de AssisLeonardo V. Monteiro de AssisAna Maria de Lauro CastrucciAna Maria de Lauro CastrucciFrontiers Media S.A.articleDanio reriotemperaturehormonesclock geneshormone receptorsPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Danio rerio temperature hormones clock genes hormone receptors Physiology QP1-981
spellingShingle	Danio rerio temperature hormones clock genes hormone receptors Physiology QP1-981 Cristhian D. Sua-Cespedes Daniela Dantas David José A. Souto-Neto Otoniel Gonçalves Lima Maria Nathália Moraes Leonardo V. Monteiro de Assis Leonardo V. Monteiro de Assis Ana Maria de Lauro Castrucci Ana Maria de Lauro Castrucci Low Temperature Effect on the Endocrine and Circadian Systems of Adult Danio rerio
description	The control of the biological rhythms begins with the activation of photo- and thermosensitive cells located in various organs of the fish such as brain, eye, and skin, but a central clock is still to be identified in teleosts. Thermal changes are stressors which increase cortisol and affect the rhythm of other hormones such as melatonin and growth hormone (GH), in both endo- and ectothermic organisms. Our aim was to investigate how temperature (23°C for 6 days) lower than the optimal (28°C) modulates expression of several gene pathways including growth hormone (gh1) and its receptors (ghra, ghrb), insulin-like growth factor1 (igf1a, igf1b) and its receptors (igf1ra, igf1rb), cortisol and its receptor (gr), the limiting enzyme of melatonin synthesis (arylalkylamine N-acetyltransferase, aanat) and melatonin receptors (mtnr1aa, mtnr1bb), as well as their relationship with clock genes in Danio rerio in early light and early dark phases of the day. Lower temperature reduced the expression of the hormone gene gh1, and of the related receptors ghra, ghrb, igf1ra, and igf1rb. Cortisol levels were higher at the lower temperature, with a decrease of its receptor (gr) transcripts in the liver. Interestingly, we found higher levels of aanat transcripts in the brain at 23°C. Overall, lower temperature downregulated the transcription of hormone related genes and clock genes. The results suggest a strong correlation of temperature challenge with the clock molecular mechanism and the endocrine systems analyzed, especially the growth hormone and melatonin axes, in D. rerio tissues.
format	article
author	Cristhian D. Sua-Cespedes Daniela Dantas David José A. Souto-Neto Otoniel Gonçalves Lima Maria Nathália Moraes Leonardo V. Monteiro de Assis Leonardo V. Monteiro de Assis Ana Maria de Lauro Castrucci Ana Maria de Lauro Castrucci
author_facet	Cristhian D. Sua-Cespedes Daniela Dantas David José A. Souto-Neto Otoniel Gonçalves Lima Maria Nathália Moraes Leonardo V. Monteiro de Assis Leonardo V. Monteiro de Assis Ana Maria de Lauro Castrucci Ana Maria de Lauro Castrucci
author_sort	Cristhian D. Sua-Cespedes
title	Low Temperature Effect on the Endocrine and Circadian Systems of Adult Danio rerio
title_short	Low Temperature Effect on the Endocrine and Circadian Systems of Adult Danio rerio
title_full	Low Temperature Effect on the Endocrine and Circadian Systems of Adult Danio rerio
title_fullStr	Low Temperature Effect on the Endocrine and Circadian Systems of Adult Danio rerio
title_full_unstemmed	Low Temperature Effect on the Endocrine and Circadian Systems of Adult Danio rerio
title_sort	low temperature effect on the endocrine and circadian systems of adult danio rerio
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d7b5fec0a4e94b0a962d3f41cbfe5be8
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Low Temperature Effect on the Endocrine and Circadian Systems of Adult Danio rerio

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