Bioengineered embryoids mimic post-implantation development in vitro

Previous approaches to derive embryoids either lack physiological morphology and signaling interactions, or are unconducive to model post-gastrulation development. Here the authors use a high-throughput approach to induce mouse embryonic stem cells into epiblast-like aggregates, which are then co-cu...

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Autores principales:	Mehmet U. Girgin, Nicolas Broguiere, Sylke Hoehnel, Nathalie Brandenberg, Bastien Mercier, Alfonso Martinez Arias, Matthias P. Lutolf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d7b6600beff74aaeac98ceb5354dc6d2
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spelling	oai:doaj.org-article:d7b6600beff74aaeac98ceb5354dc6d22021-12-02T15:09:18ZBioengineered embryoids mimic post-implantation development in vitro10.1038/s41467-021-25237-82041-1723https://doaj.org/article/d7b6600beff74aaeac98ceb5354dc6d22021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25237-8https://doaj.org/toc/2041-1723Previous approaches to derive embryoids either lack physiological morphology and signaling interactions, or are unconducive to model post-gastrulation development. Here the authors use a high-throughput approach to induce mouse embryonic stem cells into epiblast-like aggregates, which are then co-cultured with mouse trophoblast stem cell aggregates, to yield embryoids with axial morphogenesis and anterior development.Mehmet U. GirginNicolas BroguiereSylke HoehnelNathalie BrandenbergBastien MercierAlfonso Martinez AriasMatthias P. LutolfNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mehmet U. Girgin Nicolas Broguiere Sylke Hoehnel Nathalie Brandenberg Bastien Mercier Alfonso Martinez Arias Matthias P. Lutolf Bioengineered embryoids mimic post-implantation development in vitro
description	Previous approaches to derive embryoids either lack physiological morphology and signaling interactions, or are unconducive to model post-gastrulation development. Here the authors use a high-throughput approach to induce mouse embryonic stem cells into epiblast-like aggregates, which are then co-cultured with mouse trophoblast stem cell aggregates, to yield embryoids with axial morphogenesis and anterior development.
format	article
author	Mehmet U. Girgin Nicolas Broguiere Sylke Hoehnel Nathalie Brandenberg Bastien Mercier Alfonso Martinez Arias Matthias P. Lutolf
author_facet	Mehmet U. Girgin Nicolas Broguiere Sylke Hoehnel Nathalie Brandenberg Bastien Mercier Alfonso Martinez Arias Matthias P. Lutolf
author_sort	Mehmet U. Girgin
title	Bioengineered embryoids mimic post-implantation development in vitro
title_short	Bioengineered embryoids mimic post-implantation development in vitro
title_full	Bioengineered embryoids mimic post-implantation development in vitro
title_fullStr	Bioengineered embryoids mimic post-implantation development in vitro
title_full_unstemmed	Bioengineered embryoids mimic post-implantation development in vitro
title_sort	bioengineered embryoids mimic post-implantation development in vitro
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d7b6600beff74aaeac98ceb5354dc6d2
work_keys_str_mv	AT mehmetugirgin bioengineeredembryoidsmimicpostimplantationdevelopmentinvitro AT nicolasbroguiere bioengineeredembryoidsmimicpostimplantationdevelopmentinvitro AT sylkehoehnel bioengineeredembryoidsmimicpostimplantationdevelopmentinvitro AT nathaliebrandenberg bioengineeredembryoidsmimicpostimplantationdevelopmentinvitro AT bastienmercier bioengineeredembryoidsmimicpostimplantationdevelopmentinvitro AT alfonsomartinezarias bioengineeredembryoidsmimicpostimplantationdevelopmentinvitro AT matthiasplutolf bioengineeredembryoidsmimicpostimplantationdevelopmentinvitro
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Bioengineered embryoids mimic post-implantation development in vitro

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