BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy

Abstract The second near infrared window is considered to be the optimal optical window for medical imaging and therapy as its capability of deep tissue penetration. The preparation of the gold nanorods with long wavelength absorption and low cytotoxicity is still a challenge. A series gold nanorods...

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Autores principales:	Shubi Zhao, Yiqun Luo, Zong Chang, Chenchen Liu, Tong Li, Lu Gan, Yong Huang, Qinchao Sun
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	BSA-coated gold nanorods Near-infrared-II Photothermal therapy Materials of engineering and construction. Mechanics of materials TA401-492
Acceso en línea:	https://doaj.org/article/d7b8e4b64f4444409504bd2ace6b0fa6
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spelling	oai:doaj.org-article:d7b8e4b64f4444409504bd2ace6b0fa62021-12-05T12:23:53ZBSA-Coated Gold Nanorods for NIR-II Photothermal Therapy10.1186/s11671-021-03627-71556-276Xhttps://doaj.org/article/d7b8e4b64f4444409504bd2ace6b0fa62021-11-01T00:00:00Zhttps://doi.org/10.1186/s11671-021-03627-7https://doaj.org/toc/1556-276XAbstract The second near infrared window is considered to be the optimal optical window for medical imaging and therapy as its capability of deep tissue penetration. The preparation of the gold nanorods with long wavelength absorption and low cytotoxicity is still a challenge. A series gold nanorods with large aspect ratio have been synthesized. Strong plasma absorption in the second near infrared window from 1000 to 1300 nm could be observed. The biocompatibility of the synthesized gold nanorods is dramatically improved via coating by bovine serum albumin (BSA), while the optical properties of which remains. The breast cancer tumor-bearing mouse could be well treated by the prepared gold nanorods with the NIR-II light intensity as low as 0.75 W/cm2. In summary, these results demonstrate the feasibility of using low illumination dose to treat tumor in the NIR-II region via the large aspect ratio gould nanoparticles.Shubi ZhaoYiqun LuoZong ChangChenchen LiuTong LiLu GanYong HuangQinchao SunSpringerOpenarticleBSA-coated gold nanorodsNear-infrared-IIPhotothermal therapyMaterials of engineering and construction. Mechanics of materialsTA401-492ENNanoscale Research Letters, Vol 16, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	BSA-coated gold nanorods Near-infrared-II Photothermal therapy Materials of engineering and construction. Mechanics of materials TA401-492
spellingShingle	BSA-coated gold nanorods Near-infrared-II Photothermal therapy Materials of engineering and construction. Mechanics of materials TA401-492 Shubi Zhao Yiqun Luo Zong Chang Chenchen Liu Tong Li Lu Gan Yong Huang Qinchao Sun BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy
description	Abstract The second near infrared window is considered to be the optimal optical window for medical imaging and therapy as its capability of deep tissue penetration. The preparation of the gold nanorods with long wavelength absorption and low cytotoxicity is still a challenge. A series gold nanorods with large aspect ratio have been synthesized. Strong plasma absorption in the second near infrared window from 1000 to 1300 nm could be observed. The biocompatibility of the synthesized gold nanorods is dramatically improved via coating by bovine serum albumin (BSA), while the optical properties of which remains. The breast cancer tumor-bearing mouse could be well treated by the prepared gold nanorods with the NIR-II light intensity as low as 0.75 W/cm2. In summary, these results demonstrate the feasibility of using low illumination dose to treat tumor in the NIR-II region via the large aspect ratio gould nanoparticles.
format	article
author	Shubi Zhao Yiqun Luo Zong Chang Chenchen Liu Tong Li Lu Gan Yong Huang Qinchao Sun
author_facet	Shubi Zhao Yiqun Luo Zong Chang Chenchen Liu Tong Li Lu Gan Yong Huang Qinchao Sun
author_sort	Shubi Zhao
title	BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy
title_short	BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy
title_full	BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy
title_fullStr	BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy
title_full_unstemmed	BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy
title_sort	bsa-coated gold nanorods for nir-ii photothermal therapy
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/d7b8e4b64f4444409504bd2ace6b0fa6
work_keys_str_mv	AT shubizhao bsacoatedgoldnanorodsforniriiphotothermaltherapy AT yiqunluo bsacoatedgoldnanorodsforniriiphotothermaltherapy AT zongchang bsacoatedgoldnanorodsforniriiphotothermaltherapy AT chenchenliu bsacoatedgoldnanorodsforniriiphotothermaltherapy AT tongli bsacoatedgoldnanorodsforniriiphotothermaltherapy AT lugan bsacoatedgoldnanorodsforniriiphotothermaltherapy AT yonghuang bsacoatedgoldnanorodsforniriiphotothermaltherapy AT qinchaosun bsacoatedgoldnanorodsforniriiphotothermaltherapy
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BSA-Coated Gold Nanorods for NIR-II Photothermal Therapy

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