Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension

Abstract Background Urine albumin/creatinine ratio (UACR) is an important marker of early renal damage (ERD) caused by hypertension. Recent studies showed that blood pressure was a significant inverse association with temperature and climate. The purposes of our study were sought to explore the asso...

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Autores principales:	Yuzhuo Zhang, Ying Zhao, Chenglu Wei, Yongrong Li, Hira Aslam, Qingmin Feng, Qing Huang, Yu Zheng, Feifen Lv, Wei Hao, Jike Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Chinese tropics Early renal damage Essential hypertension Urine albumin/creatinine ratio Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/d7bd06da72dd40599df8357ad6ba35c8
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spelling	oai:doaj.org-article:d7bd06da72dd40599df8357ad6ba35c82021-11-08T11:18:02ZAssociation of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension10.1186/s12882-021-02576-81471-2369https://doaj.org/article/d7bd06da72dd40599df8357ad6ba35c82021-11-01T00:00:00Zhttps://doi.org/10.1186/s12882-021-02576-8https://doaj.org/toc/1471-2369Abstract Background Urine albumin/creatinine ratio (UACR) is an important marker of early renal damage (ERD) caused by hypertension. Recent studies showed that blood pressure was a significant inverse association with temperature and climate. The purposes of our study were sought to explore the association of common medical comorbidities with ERD, and find independent risk factors to ERD in Chinese tropics with essential hypertension. Methods From January 2018 to December 2019, we assessed UACR in a total of 599 hypertensive Chinese Hainan patients. We defined ERD as a UACR between 30 mg/g and 300 mg/g. We analysed differences between qualitative variables using the chi-squared (χ2) test. We calculated correlations between UACR and age, hypertension duration (HD), systolic blood pressure (SBP), and diastolic blood pressure (DBP) using the Spearman’s rho test. To determine the odds ratio (OR), we evaluated binary logistic regression models. Results Among the 599 patients, 281 (46.9%) were found to have ERD. ERD and factors related to sex, body mass index (BMI), and SBP did not differ significantly (all, p>0.05). Our main findings showed that age, HD, and DBP were associated with ERD (p<0.01, respectively). Furthermore, age ≥ 65 years, HD ≥10 years, DBP ≥ 90 mmHg, SBP ≥ 160 mmHg, and diabetes differed significantly according to ERD status (p < 0.05, respectively). In multivariate analysis using stepwise regression, age (OR = 1.468), DBP (OR = 1.853), and diabetes (OR = 2.031) were significant independent predictors of ERD. The area under the receiver operating characteristic (ROC) curve was 0.677, and the sensitivity and specificity of the optimal cut-off value were 44.5 and 81.1%, respectively. Conclusions Common medical comorbidities are associated with ERD; age, DBP, and diabetes are independent risk factors for ERD in patients with essential hypertension who live in the Chinese tropics. Early monitoring of the UACR, as well as control of blood glucose and DBP, can effectively delay ERD.Yuzhuo ZhangYing ZhaoChenglu WeiYongrong LiHira AslamQingmin FengQing HuangYu ZhengFeifen LvWei HaoJike LiBMCarticleChinese tropicsEarly renal damageEssential hypertensionUrine albumin/creatinine ratioDiseases of the genitourinary system. UrologyRC870-923ENBMC Nephrology, Vol 22, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chinese tropics Early renal damage Essential hypertension Urine albumin/creatinine ratio Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Chinese tropics Early renal damage Essential hypertension Urine albumin/creatinine ratio Diseases of the genitourinary system. Urology RC870-923 Yuzhuo Zhang Ying Zhao Chenglu Wei Yongrong Li Hira Aslam Qingmin Feng Qing Huang Yu Zheng Feifen Lv Wei Hao Jike Li Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension
description	Abstract Background Urine albumin/creatinine ratio (UACR) is an important marker of early renal damage (ERD) caused by hypertension. Recent studies showed that blood pressure was a significant inverse association with temperature and climate. The purposes of our study were sought to explore the association of common medical comorbidities with ERD, and find independent risk factors to ERD in Chinese tropics with essential hypertension. Methods From January 2018 to December 2019, we assessed UACR in a total of 599 hypertensive Chinese Hainan patients. We defined ERD as a UACR between 30 mg/g and 300 mg/g. We analysed differences between qualitative variables using the chi-squared (χ2) test. We calculated correlations between UACR and age, hypertension duration (HD), systolic blood pressure (SBP), and diastolic blood pressure (DBP) using the Spearman’s rho test. To determine the odds ratio (OR), we evaluated binary logistic regression models. Results Among the 599 patients, 281 (46.9%) were found to have ERD. ERD and factors related to sex, body mass index (BMI), and SBP did not differ significantly (all, p>0.05). Our main findings showed that age, HD, and DBP were associated with ERD (p<0.01, respectively). Furthermore, age ≥ 65 years, HD ≥10 years, DBP ≥ 90 mmHg, SBP ≥ 160 mmHg, and diabetes differed significantly according to ERD status (p < 0.05, respectively). In multivariate analysis using stepwise regression, age (OR = 1.468), DBP (OR = 1.853), and diabetes (OR = 2.031) were significant independent predictors of ERD. The area under the receiver operating characteristic (ROC) curve was 0.677, and the sensitivity and specificity of the optimal cut-off value were 44.5 and 81.1%, respectively. Conclusions Common medical comorbidities are associated with ERD; age, DBP, and diabetes are independent risk factors for ERD in patients with essential hypertension who live in the Chinese tropics. Early monitoring of the UACR, as well as control of blood glucose and DBP, can effectively delay ERD.
format	article
author	Yuzhuo Zhang Ying Zhao Chenglu Wei Yongrong Li Hira Aslam Qingmin Feng Qing Huang Yu Zheng Feifen Lv Wei Hao Jike Li
author_facet	Yuzhuo Zhang Ying Zhao Chenglu Wei Yongrong Li Hira Aslam Qingmin Feng Qing Huang Yu Zheng Feifen Lv Wei Hao Jike Li
author_sort	Yuzhuo Zhang
title	Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension
title_short	Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension
title_full	Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension
title_fullStr	Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension
title_full_unstemmed	Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension
title_sort	association of common medical comorbidities with early renal damage in the chinese tropics with essential hypertension
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d7bd06da72dd40599df8357ad6ba35c8
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Association of common medical comorbidities with early renal damage in the Chinese tropics with essential hypertension

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