Behavioral Characteristics of Gout Patients and Their Impact on the Results of Urate Lowering Therapy

Background. Gout is frequently accompanied by hypertension, obesity, and/or impaired glucose tolerance, which are often complicated with heavy smoking and dietary violations, especially in male patients.Objective. To determine the behavioral characteristics of gout patients that could impact the res...

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Autores principales:	J. Chen, P. Zhou, W. Tan, M. Zheng, N. Y. Oshmianska
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	gout urate lowering therapy smoking uric acid Science Q
Acceso en línea:	https://doaj.org/article/d7bd500fd6344064a4d9e40d9901fdb3
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spelling	oai:doaj.org-article:d7bd500fd6344064a4d9e40d9901fdb32021-11-23T06:14:45ZBehavioral Characteristics of Gout Patients and Their Impact on the Results of Urate Lowering Therapy2541-94202587-959610.29413/ABS.2021-6.1.2https://doaj.org/article/d7bd500fd6344064a4d9e40d9901fdb32021-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2605https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Gout is frequently accompanied by hypertension, obesity, and/or impaired glucose tolerance, which are often complicated with heavy smoking and dietary violations, especially in male patients.Objective. To determine the behavioral characteristics of gout patients that could impact the results of urate lowering therapy.Subjects and methods. The relationship between behavioral characteristics and results of urate lowering therapy were investigated in 74 male gout patients of Chengdu Rheumatism Hospital. The results of treatment were evaluated using serum uric acid contents before and after treatment, VAS pain score before and after treatment. Behavioral characteristics for the last ten years (smoking status, daily volume of drinking water, etc.) were accessed by means of retrospective survey.Results. In gout patients with poor treatment response, serum uric acid at the beginning of the treatment was already significantly lower (365.76 ± 163.06 μmol/L); this trend was also noted in a “slow progress” group, while patients with higher serum uric acid before treatment had notably better response to urate lowering therapy. During further analysis age negatively correlated with serum uric acid (r = –0.328; p = 0.002) and uric acid clearance ratio (r = –0.299; p = 0.002).In patients with uric acid clearance ratio above 40 % the prevalence of kidney diseases (stones or dysfunction) was significantly lower compared to other groups. There was no significant influence of hypertension, diabetes mellitus, fatty liver or hyperlipidaemia on uric acid clearance ratio (p > 0.05).Amount of drinking water also influenced the serum uric acid clearance ratio. Bigger amount of patients in the “fast progress” group (40.0 % compared to 30.44 and 25.0 %) tended to drink more water.Conclusion. In most gout patients, serum uric acid levels before treatment acted as the reliable predictor of good response to urate lowering therapy. Treatment response (serum uric acid clearance ratio) correlated positively with the hyperuricemia and drinking sufficient amounts of water, negatively – with prolonged smoking (more than 10 years) and age.J. ChenP. ZhouW. TanM. ZhengN. Y. OshmianskaScientific Сentre for Family Health and Human Reproduction Problemsarticlegouturate lowering therapysmokinguric acidScienceQRUActa Biomedica Scientifica, Vol 6, Iss 1, Pp 13-17 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	gout urate lowering therapy smoking uric acid Science Q
spellingShingle	gout urate lowering therapy smoking uric acid Science Q J. Chen P. Zhou W. Tan M. Zheng N. Y. Oshmianska Behavioral Characteristics of Gout Patients and Their Impact on the Results of Urate Lowering Therapy
description	Background. Gout is frequently accompanied by hypertension, obesity, and/or impaired glucose tolerance, which are often complicated with heavy smoking and dietary violations, especially in male patients.Objective. To determine the behavioral characteristics of gout patients that could impact the results of urate lowering therapy.Subjects and methods. The relationship between behavioral characteristics and results of urate lowering therapy were investigated in 74 male gout patients of Chengdu Rheumatism Hospital. The results of treatment were evaluated using serum uric acid contents before and after treatment, VAS pain score before and after treatment. Behavioral characteristics for the last ten years (smoking status, daily volume of drinking water, etc.) were accessed by means of retrospective survey.Results. In gout patients with poor treatment response, serum uric acid at the beginning of the treatment was already significantly lower (365.76 ± 163.06 μmol/L); this trend was also noted in a “slow progress” group, while patients with higher serum uric acid before treatment had notably better response to urate lowering therapy. During further analysis age negatively correlated with serum uric acid (r = –0.328; p = 0.002) and uric acid clearance ratio (r = –0.299; p = 0.002).In patients with uric acid clearance ratio above 40 % the prevalence of kidney diseases (stones or dysfunction) was significantly lower compared to other groups. There was no significant influence of hypertension, diabetes mellitus, fatty liver or hyperlipidaemia on uric acid clearance ratio (p > 0.05).Amount of drinking water also influenced the serum uric acid clearance ratio. Bigger amount of patients in the “fast progress” group (40.0 % compared to 30.44 and 25.0 %) tended to drink more water.Conclusion. In most gout patients, serum uric acid levels before treatment acted as the reliable predictor of good response to urate lowering therapy. Treatment response (serum uric acid clearance ratio) correlated positively with the hyperuricemia and drinking sufficient amounts of water, negatively – with prolonged smoking (more than 10 years) and age.
format	article
author	J. Chen P. Zhou W. Tan M. Zheng N. Y. Oshmianska
author_facet	J. Chen P. Zhou W. Tan M. Zheng N. Y. Oshmianska
author_sort	J. Chen
title	Behavioral Characteristics of Gout Patients and Their Impact on the Results of Urate Lowering Therapy
title_short	Behavioral Characteristics of Gout Patients and Their Impact on the Results of Urate Lowering Therapy
title_full	Behavioral Characteristics of Gout Patients and Their Impact on the Results of Urate Lowering Therapy
title_fullStr	Behavioral Characteristics of Gout Patients and Their Impact on the Results of Urate Lowering Therapy
title_full_unstemmed	Behavioral Characteristics of Gout Patients and Their Impact on the Results of Urate Lowering Therapy
title_sort	behavioral characteristics of gout patients and their impact on the results of urate lowering therapy
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/d7bd500fd6344064a4d9e40d9901fdb3
work_keys_str_mv	AT jchen behavioralcharacteristicsofgoutpatientsandtheirimpactontheresultsofurateloweringtherapy AT pzhou behavioralcharacteristicsofgoutpatientsandtheirimpactontheresultsofurateloweringtherapy AT wtan behavioralcharacteristicsofgoutpatientsandtheirimpactontheresultsofurateloweringtherapy AT mzheng behavioralcharacteristicsofgoutpatientsandtheirimpactontheresultsofurateloweringtherapy AT nyoshmianska behavioralcharacteristicsofgoutpatientsandtheirimpactontheresultsofurateloweringtherapy
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Behavioral Characteristics of Gout Patients and Their Impact on the Results of Urate Lowering Therapy

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