IgA pemphigus showing IgA antibodies to desmoglein 1 and 3

Background: IgA pemphigus is a rare autoimmune vesiculo-pustular skin disease. Only approximately 70 cases have been reported to date. We report a case of IgA pemphigus with IgA antibodies to desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3). Case report: We report the case of an 60-year-old man with...

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Autores principales:	Salama Hegazy, Sana Bouchouicha, Aida Khaled, Lilia Laadher, Maryem Kallel Sellami, Faten Zeglaoui
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2016
Materias:	pemphigus IgA pemphigus desmoglein Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/d7c1014b9faf4e5d914c4fe6852ffb5a
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spelling	oai:doaj.org-article:d7c1014b9faf4e5d914c4fe6852ffb5a2021-11-17T08:30:57ZIgA pemphigus showing IgA antibodies to desmoglein 1 and 310.5826/dpc.0604a072160-9381https://doaj.org/article/d7c1014b9faf4e5d914c4fe6852ffb5a2016-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/203https://doaj.org/toc/2160-9381 Background: IgA pemphigus is a rare autoimmune vesiculo-pustular skin disease. Only approximately 70 cases have been reported to date. We report a case of IgA pemphigus with IgA antibodies to desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3). Case report: We report the case of an 60-year-old man with intraepidermal neutrophilic IgA pemphigus with IgA antibodies to Dsg1 and Dsg3. Histologic examination revealed subcorneal neutrophilic pustules with few acantholytic cells. The disease was not effectively controlled by conventional therapeutic regimens (colchicine, dapsone). Systemic treatment with isotretinoin 25 mg/d and prednisone 20 mg/d achieved only a slight effect after six months. Conclusions: Our case confirmed the recalcitrant nature of IgA pemphigus in response to distinct therapies, indicating that further research focusing on therapeutic approaches for this type of pemphigus is needed. Physicians should keep IgA pemphigus in mind when approaching patients with bullous eruption. Salama HegazySana BouchouichaAida KhaledLilia LaadherMaryem Kallel SellamiFaten ZeglaouiMattioli1885articlepemphigusIgA pemphigusdesmogleinDermatologyRL1-803ENDermatology Practical & Conceptual (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	pemphigus IgA pemphigus desmoglein Dermatology RL1-803
spellingShingle	pemphigus IgA pemphigus desmoglein Dermatology RL1-803 Salama Hegazy Sana Bouchouicha Aida Khaled Lilia Laadher Maryem Kallel Sellami Faten Zeglaoui IgA pemphigus showing IgA antibodies to desmoglein 1 and 3
description	Background: IgA pemphigus is a rare autoimmune vesiculo-pustular skin disease. Only approximately 70 cases have been reported to date. We report a case of IgA pemphigus with IgA antibodies to desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3). Case report: We report the case of an 60-year-old man with intraepidermal neutrophilic IgA pemphigus with IgA antibodies to Dsg1 and Dsg3. Histologic examination revealed subcorneal neutrophilic pustules with few acantholytic cells. The disease was not effectively controlled by conventional therapeutic regimens (colchicine, dapsone). Systemic treatment with isotretinoin 25 mg/d and prednisone 20 mg/d achieved only a slight effect after six months. Conclusions: Our case confirmed the recalcitrant nature of IgA pemphigus in response to distinct therapies, indicating that further research focusing on therapeutic approaches for this type of pemphigus is needed. Physicians should keep IgA pemphigus in mind when approaching patients with bullous eruption.
format	article
author	Salama Hegazy Sana Bouchouicha Aida Khaled Lilia Laadher Maryem Kallel Sellami Faten Zeglaoui
author_facet	Salama Hegazy Sana Bouchouicha Aida Khaled Lilia Laadher Maryem Kallel Sellami Faten Zeglaoui
author_sort	Salama Hegazy
title	IgA pemphigus showing IgA antibodies to desmoglein 1 and 3
title_short	IgA pemphigus showing IgA antibodies to desmoglein 1 and 3
title_full	IgA pemphigus showing IgA antibodies to desmoglein 1 and 3
title_fullStr	IgA pemphigus showing IgA antibodies to desmoglein 1 and 3
title_full_unstemmed	IgA pemphigus showing IgA antibodies to desmoglein 1 and 3
title_sort	iga pemphigus showing iga antibodies to desmoglein 1 and 3
publisher	Mattioli1885
publishDate	2016
url	https://doaj.org/article/d7c1014b9faf4e5d914c4fe6852ffb5a
work_keys_str_mv	AT salamahegazy igapemphigusshowingigaantibodiestodesmoglein1and3 AT sanabouchouicha igapemphigusshowingigaantibodiestodesmoglein1and3 AT aidakhaled igapemphigusshowingigaantibodiestodesmoglein1and3 AT lilialaadher igapemphigusshowingigaantibodiestodesmoglein1and3 AT maryemkallelsellami igapemphigusshowingigaantibodiestodesmoglein1and3 AT fatenzeglaoui igapemphigusshowingigaantibodiestodesmoglein1and3
_version_	1718425768087781376

IgA pemphigus showing IgA antibodies to desmoglein 1 and 3

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