Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

Cancer cells reprogramme their metabolism with unclear clinical implications. Here, the authors analyse the expression of metabolic genes across 20 types of solid cancers and find that clinical aggressiveness, poor survival and metastasis are associated with the deregulation of mitochondrial metabol...

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Autores principales:	Edoardo Gaude, Christian Frezza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d7c13a69fec74620bf503ac30045849d
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spelling	oai:doaj.org-article:d7c13a69fec74620bf503ac30045849d2021-12-02T17:31:35ZTissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival10.1038/ncomms130412041-1723https://doaj.org/article/d7c13a69fec74620bf503ac30045849d2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13041https://doaj.org/toc/2041-1723Cancer cells reprogramme their metabolism with unclear clinical implications. Here, the authors analyse the expression of metabolic genes across 20 types of solid cancers and find that clinical aggressiveness, poor survival and metastasis are associated with the deregulation of mitochondrial metabolism.Edoardo GaudeChristian FrezzaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Edoardo Gaude Christian Frezza Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
description	Cancer cells reprogramme their metabolism with unclear clinical implications. Here, the authors analyse the expression of metabolic genes across 20 types of solid cancers and find that clinical aggressiveness, poor survival and metastasis are associated with the deregulation of mitochondrial metabolism.
format	article
author	Edoardo Gaude Christian Frezza
author_facet	Edoardo Gaude Christian Frezza
author_sort	Edoardo Gaude
title	Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
title_short	Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
title_full	Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
title_fullStr	Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
title_full_unstemmed	Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
title_sort	tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d7c13a69fec74620bf503ac30045849d
work_keys_str_mv	AT edoardogaude tissuespecificandconvergentmetabolictransformationofcancercorrelateswithmetastaticpotentialandpatientsurvival AT christianfrezza tissuespecificandconvergentmetabolictransformationofcancercorrelateswithmetastaticpotentialandpatientsurvival
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Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

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