Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal

CPSF6 is a cellular factor that regulates cleavage and polyadenylation of mRNAs and participates in HIV-1 infection by facilitating targeting of preintegration complexes to the chromatin. Our observations reveal a second role of CPSF6 in the HIV-1 life cycle that involves regulation of viral transc...

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Autores principales:	Yue Zheng, Heidi L. Schubert, Parmit K. Singh, Laura J. Martins, Alan N. Engelman, Iván D’Orso, Christopher P. Hill, Vicente Planelles
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d7c36d3d4feb42ee994b4fd477199f64
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spelling	oai:doaj.org-article:d7c36d3d4feb42ee994b4fd477199f642021-11-03T21:15:04ZCleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal2150-751110.1128/mBio.01098-21https://doaj.org/article/d7c36d3d4feb42ee994b4fd477199f642021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01098-21https://doaj.org/toc/2150-7511 CPSF6 is a cellular factor that regulates cleavage and polyadenylation of mRNAs and participates in HIV-1 infection by facilitating targeting of preintegration complexes to the chromatin. Our observations reveal a second role of CPSF6 in the HIV-1 life cycle that involves regulation of viral transcription through controlling the stability of protein phosphatase 2A, which in turn regulates the phosphorylation/dephosphorylation status of critical residues in CDK9 and Pol II.Yue ZhengHeidi L. SchubertParmit K. SinghLaura J. MartinsAlan N. EngelmanIván D’OrsoChristopher P. HillVicente PlanellesAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Yue Zheng Heidi L. Schubert Parmit K. Singh Laura J. Martins Alan N. Engelman Iván D’Orso Christopher P. Hill Vicente Planelles Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal
description	CPSF6 is a cellular factor that regulates cleavage and polyadenylation of mRNAs and participates in HIV-1 infection by facilitating targeting of preintegration complexes to the chromatin. Our observations reveal a second role of CPSF6 in the HIV-1 life cycle that involves regulation of viral transcription through controlling the stability of protein phosphatase 2A, which in turn regulates the phosphorylation/dephosphorylation status of critical residues in CDK9 and Pol II.
format	article
author	Yue Zheng Heidi L. Schubert Parmit K. Singh Laura J. Martins Alan N. Engelman Iván D’Orso Christopher P. Hill Vicente Planelles
author_facet	Yue Zheng Heidi L. Schubert Parmit K. Singh Laura J. Martins Alan N. Engelman Iván D’Orso Christopher P. Hill Vicente Planelles
author_sort	Yue Zheng
title	Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal
title_short	Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal
title_full	Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal
title_fullStr	Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal
title_full_unstemmed	Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal
title_sort	cleavage and polyadenylation specificity factor 6 is required for efficient hiv-1 latency reversal
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/d7c36d3d4feb42ee994b4fd477199f64
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Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal

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