Cognitive ability and physical health: a Mendelian randomization study

Abstract Causes of the association between cognitive ability and health remain unknown, but may reflect a shared genetic aetiology. This study examines the causal genetic associations between cognitive ability and physical health. We carried out two-sample Mendelian randomization analyses using the...

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Autores principales:	Saskia P. Hagenaars, Catharine R. Gale, Ian J. Deary, Sarah E. Harris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d7c7214413a94b3b84afc95a44287733
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spelling	oai:doaj.org-article:d7c7214413a94b3b84afc95a442877332021-12-02T12:31:47ZCognitive ability and physical health: a Mendelian randomization study10.1038/s41598-017-02837-32045-2322https://doaj.org/article/d7c7214413a94b3b84afc95a442877332017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02837-3https://doaj.org/toc/2045-2322Abstract Causes of the association between cognitive ability and health remain unknown, but may reflect a shared genetic aetiology. This study examines the causal genetic associations between cognitive ability and physical health. We carried out two-sample Mendelian randomization analyses using the inverse-variance weighted method to test for causality between later life cognitive ability, educational attainment (as a proxy for cognitive ability in youth), BMI, height, systolic blood pressure, coronary artery disease, and type 2 diabetes using data from six independent GWAS consortia and the UK Biobank sample (N = 112 151). BMI, systolic blood pressure, coronary artery disease and type 2 diabetes showed negative associations with cognitive ability; height was positively associated with cognitive ability. The analyses provided no evidence for casual associations from health to cognitive ability. In the other direction, higher educational attainment predicted lower BMI, systolic blood pressure, coronary artery disease, type 2 diabetes, and taller stature. The analyses indicated no causal association from educational attainment to physical health. The lack of evidence for causal associations between cognitive ability, educational attainment, and physical health could be explained by weak instrumental variables, poorly measured outcomes, or the small number of disease cases.Saskia P. HagenaarsCatharine R. GaleIan J. DearySarah E. HarrisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Saskia P. Hagenaars Catharine R. Gale Ian J. Deary Sarah E. Harris Cognitive ability and physical health: a Mendelian randomization study
description	Abstract Causes of the association between cognitive ability and health remain unknown, but may reflect a shared genetic aetiology. This study examines the causal genetic associations between cognitive ability and physical health. We carried out two-sample Mendelian randomization analyses using the inverse-variance weighted method to test for causality between later life cognitive ability, educational attainment (as a proxy for cognitive ability in youth), BMI, height, systolic blood pressure, coronary artery disease, and type 2 diabetes using data from six independent GWAS consortia and the UK Biobank sample (N = 112 151). BMI, systolic blood pressure, coronary artery disease and type 2 diabetes showed negative associations with cognitive ability; height was positively associated with cognitive ability. The analyses provided no evidence for casual associations from health to cognitive ability. In the other direction, higher educational attainment predicted lower BMI, systolic blood pressure, coronary artery disease, type 2 diabetes, and taller stature. The analyses indicated no causal association from educational attainment to physical health. The lack of evidence for causal associations between cognitive ability, educational attainment, and physical health could be explained by weak instrumental variables, poorly measured outcomes, or the small number of disease cases.
format	article
author	Saskia P. Hagenaars Catharine R. Gale Ian J. Deary Sarah E. Harris
author_facet	Saskia P. Hagenaars Catharine R. Gale Ian J. Deary Sarah E. Harris
author_sort	Saskia P. Hagenaars
title	Cognitive ability and physical health: a Mendelian randomization study
title_short	Cognitive ability and physical health: a Mendelian randomization study
title_full	Cognitive ability and physical health: a Mendelian randomization study
title_fullStr	Cognitive ability and physical health: a Mendelian randomization study
title_full_unstemmed	Cognitive ability and physical health: a Mendelian randomization study
title_sort	cognitive ability and physical health: a mendelian randomization study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d7c7214413a94b3b84afc95a44287733
work_keys_str_mv	AT saskiaphagenaars cognitiveabilityandphysicalhealthamendelianrandomizationstudy AT catharinergale cognitiveabilityandphysicalhealthamendelianrandomizationstudy AT ianjdeary cognitiveabilityandphysicalhealthamendelianrandomizationstudy AT saraheharris cognitiveabilityandphysicalhealthamendelianrandomizationstudy
_version_	1718394309151031296

Cognitive ability and physical health: a Mendelian randomization study

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