Environmentally Relevant Concentrations of Triclosan Induce Cyto-Genotoxicity and Biochemical Alterations in the Hatchlings of <i>Labeo rohita</i>

Xenobiotic Triclosan (TCS) is of great concern because of its existence in a variety of personal, household and healthcare products and continuous discharge in water worldwide. Excessive use of TCS-containing sanitizers and antiseptic products during the COVID-19 pandemic further increased its conte...

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Autores principales:	Sunil Sharma, Owias Iqbal Dar, Megha Andotra, Simran Sharma, Arvinder Kaur, Caterina Faggio
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	triclosan environmentally relevant concentrations <i>L. rohita</i> hatchlings cytotoxicity genotoxicity Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d7cb51f8bb7d4fffb88f48569b6b1f86
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spelling	oai:doaj.org-article:d7cb51f8bb7d4fffb88f48569b6b1f862021-11-11T15:25:12ZEnvironmentally Relevant Concentrations of Triclosan Induce Cyto-Genotoxicity and Biochemical Alterations in the Hatchlings of <i>Labeo rohita</i>10.3390/app1121104782076-3417https://doaj.org/article/d7cb51f8bb7d4fffb88f48569b6b1f862021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/10478https://doaj.org/toc/2076-3417Xenobiotic Triclosan (TCS) is of great concern because of its existence in a variety of personal, household and healthcare products and continuous discharge in water worldwide. Excessive use of TCS-containing sanitizers and antiseptic products during the COVID-19 pandemic further increased its content in aquatic ecosystems. The present study deals with the cyto-genotoxic effects and biochemical alterations in the hatchlings of <i>Labeo rohita</i> on exposure to environmentally relevant concentrations of TCS. Three-days-old hatchlings were exposed to tap water, acetone (solvent control) and 4 environmentally relevant concentrations (6.3, 12.6, 25.2 and 60 µg/L) of TCS for 14 days and kept for a recovery period of 10 days. The significant concentration-dependent decline in cell viability but increase in micronucleated cells, nucleo-cellular abnormalities (NCAs) and DNA damage parameters like tail length, tail moment, olive tail moment and percent of tail DNA after exposure persisted till the end of recovery period. Glucose, triglycerides, cholesterol, total protein, albumin, total bilirubin, uric acid and urea (except for an increase at 60 µg/L) showed significant (<i>p</i> ≤ 0.05) concentration-dependent decrease after 14 days of exposure. The same trend (except for triglycerides, albumin and total bilirubin) continued till 10 days post exposure. In comparison to control, transaminases (alanine and aspartate aminotransferases) increased (<i>p</i> ≤ 0.05) after exposure as well as the recovery period, while a decline in alkaline phosphatase after exposure was followed by a significant increase during the recovery period. The results show that the environmentally relevant concentrations of TCS cause deleterious effects on the hatchlings of <i>L. rohita</i>.Sunil SharmaOwias Iqbal DarMegha AndotraSimran SharmaArvinder KaurCaterina FaggioMDPI AGarticletriclosanenvironmentally relevant concentrations<i>L. rohita</i>hatchlingscytotoxicitygenotoxicityTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10478, p 10478 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	triclosan environmentally relevant concentrations <i>L. rohita</i> hatchlings cytotoxicity genotoxicity Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	triclosan environmentally relevant concentrations <i>L. rohita</i> hatchlings cytotoxicity genotoxicity Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Sunil Sharma Owias Iqbal Dar Megha Andotra Simran Sharma Arvinder Kaur Caterina Faggio Environmentally Relevant Concentrations of Triclosan Induce Cyto-Genotoxicity and Biochemical Alterations in the Hatchlings of <i>Labeo rohita</i>
description	Xenobiotic Triclosan (TCS) is of great concern because of its existence in a variety of personal, household and healthcare products and continuous discharge in water worldwide. Excessive use of TCS-containing sanitizers and antiseptic products during the COVID-19 pandemic further increased its content in aquatic ecosystems. The present study deals with the cyto-genotoxic effects and biochemical alterations in the hatchlings of <i>Labeo rohita</i> on exposure to environmentally relevant concentrations of TCS. Three-days-old hatchlings were exposed to tap water, acetone (solvent control) and 4 environmentally relevant concentrations (6.3, 12.6, 25.2 and 60 µg/L) of TCS for 14 days and kept for a recovery period of 10 days. The significant concentration-dependent decline in cell viability but increase in micronucleated cells, nucleo-cellular abnormalities (NCAs) and DNA damage parameters like tail length, tail moment, olive tail moment and percent of tail DNA after exposure persisted till the end of recovery period. Glucose, triglycerides, cholesterol, total protein, albumin, total bilirubin, uric acid and urea (except for an increase at 60 µg/L) showed significant (<i>p</i> ≤ 0.05) concentration-dependent decrease after 14 days of exposure. The same trend (except for triglycerides, albumin and total bilirubin) continued till 10 days post exposure. In comparison to control, transaminases (alanine and aspartate aminotransferases) increased (<i>p</i> ≤ 0.05) after exposure as well as the recovery period, while a decline in alkaline phosphatase after exposure was followed by a significant increase during the recovery period. The results show that the environmentally relevant concentrations of TCS cause deleterious effects on the hatchlings of <i>L. rohita</i>.
format	article
author	Sunil Sharma Owias Iqbal Dar Megha Andotra Simran Sharma Arvinder Kaur Caterina Faggio
author_facet	Sunil Sharma Owias Iqbal Dar Megha Andotra Simran Sharma Arvinder Kaur Caterina Faggio
author_sort	Sunil Sharma
title	Environmentally Relevant Concentrations of Triclosan Induce Cyto-Genotoxicity and Biochemical Alterations in the Hatchlings of <i>Labeo rohita</i>
title_short	Environmentally Relevant Concentrations of Triclosan Induce Cyto-Genotoxicity and Biochemical Alterations in the Hatchlings of <i>Labeo rohita</i>
title_full	Environmentally Relevant Concentrations of Triclosan Induce Cyto-Genotoxicity and Biochemical Alterations in the Hatchlings of <i>Labeo rohita</i>
title_fullStr	Environmentally Relevant Concentrations of Triclosan Induce Cyto-Genotoxicity and Biochemical Alterations in the Hatchlings of <i>Labeo rohita</i>
title_full_unstemmed	Environmentally Relevant Concentrations of Triclosan Induce Cyto-Genotoxicity and Biochemical Alterations in the Hatchlings of <i>Labeo rohita</i>
title_sort	environmentally relevant concentrations of triclosan induce cyto-genotoxicity and biochemical alterations in the hatchlings of <i>labeo rohita</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d7cb51f8bb7d4fffb88f48569b6b1f86
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Environmentally Relevant Concentrations of Triclosan Induce Cyto-Genotoxicity and Biochemical Alterations in the Hatchlings of <i>Labeo rohita</i>

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