Biochemical mechanisms determine the functional compatibility of heterologous genes

Sequence composition is thought to be a major factor governing the functionality of horizontally transferred genes. In contrast, Porse et al. show that phylogenetic origin, and the type of resistance mechanism, are major factors affecting the functionality of horizontally transferred antibiotic resi...

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Autores principales: Andreas Porse, Thea S. Schou, Christian Munck, Mostafa M. H. Ellabaan, Morten O. A. Sommer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d7cdec1e83024383a422623ea6cfcddb
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Sumario:Sequence composition is thought to be a major factor governing the functionality of horizontally transferred genes. In contrast, Porse et al. show that phylogenetic origin, and the type of resistance mechanism, are major factors affecting the functionality of horizontally transferred antibiotic resistance genes.