Biochemical mechanisms determine the functional compatibility of heterologous genes

Sequence composition is thought to be a major factor governing the functionality of horizontally transferred genes. In contrast, Porse et al. show that phylogenetic origin, and the type of resistance mechanism, are major factors affecting the functionality of horizontally transferred antibiotic resi...

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Autores principales:	Andreas Porse, Thea S. Schou, Christian Munck, Mostafa M. H. Ellabaan, Morten O. A. Sommer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d7cdec1e83024383a422623ea6cfcddb
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spelling	oai:doaj.org-article:d7cdec1e83024383a422623ea6cfcddb2021-12-02T14:39:09ZBiochemical mechanisms determine the functional compatibility of heterologous genes10.1038/s41467-018-02944-32041-1723https://doaj.org/article/d7cdec1e83024383a422623ea6cfcddb2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02944-3https://doaj.org/toc/2041-1723Sequence composition is thought to be a major factor governing the functionality of horizontally transferred genes. In contrast, Porse et al. show that phylogenetic origin, and the type of resistance mechanism, are major factors affecting the functionality of horizontally transferred antibiotic resistance genes.Andreas PorseThea S. SchouChristian MunckMostafa M. H. EllabaanMorten O. A. SommerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andreas Porse Thea S. Schou Christian Munck Mostafa M. H. Ellabaan Morten O. A. Sommer Biochemical mechanisms determine the functional compatibility of heterologous genes
description	Sequence composition is thought to be a major factor governing the functionality of horizontally transferred genes. In contrast, Porse et al. show that phylogenetic origin, and the type of resistance mechanism, are major factors affecting the functionality of horizontally transferred antibiotic resistance genes.
format	article
author	Andreas Porse Thea S. Schou Christian Munck Mostafa M. H. Ellabaan Morten O. A. Sommer
author_facet	Andreas Porse Thea S. Schou Christian Munck Mostafa M. H. Ellabaan Morten O. A. Sommer
author_sort	Andreas Porse
title	Biochemical mechanisms determine the functional compatibility of heterologous genes
title_short	Biochemical mechanisms determine the functional compatibility of heterologous genes
title_full	Biochemical mechanisms determine the functional compatibility of heterologous genes
title_fullStr	Biochemical mechanisms determine the functional compatibility of heterologous genes
title_full_unstemmed	Biochemical mechanisms determine the functional compatibility of heterologous genes
title_sort	biochemical mechanisms determine the functional compatibility of heterologous genes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d7cdec1e83024383a422623ea6cfcddb
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Biochemical mechanisms determine the functional compatibility of heterologous genes

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