Drug design from the cryptic inhibitor envelope

The conformational dynamics of a compound has a large effect on ligand/receptor binding. Here, the authors employ NMR spectroscopy to study ligand binding to the enzyme LpxC, discovering an inhibitor envelope that was not identifiable by crystallography and subsequently developing a highly potent in...

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Main Authors:	Chul-Jin Lee, Xiaofei Liang, Qinglin Wu, Javaria Najeeb, Jinshi Zhao, Ramesh Gopalaswamy, Marie Titecat, Florent Sebbane, Nadine Lemaitre, Eric J. Toone, Pei Zhou
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/d7d0d77eb2224e92ad9e99b31e87c12f
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id	oai:doaj.org-article:d7d0d77eb2224e92ad9e99b31e87c12f
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spelling	oai:doaj.org-article:d7d0d77eb2224e92ad9e99b31e87c12f2021-12-02T14:40:13ZDrug design from the cryptic inhibitor envelope10.1038/ncomms106382041-1723https://doaj.org/article/d7d0d77eb2224e92ad9e99b31e87c12f2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10638https://doaj.org/toc/2041-1723The conformational dynamics of a compound has a large effect on ligand/receptor binding. Here, the authors employ NMR spectroscopy to study ligand binding to the enzyme LpxC, discovering an inhibitor envelope that was not identifiable by crystallography and subsequently developing a highly potent inhibitor.Chul-Jin LeeXiaofei LiangQinglin WuJavaria NajeebJinshi ZhaoRamesh GopalaswamyMarie TitecatFlorent SebbaneNadine LemaitreEric J. ToonePei ZhouNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chul-Jin Lee Xiaofei Liang Qinglin Wu Javaria Najeeb Jinshi Zhao Ramesh Gopalaswamy Marie Titecat Florent Sebbane Nadine Lemaitre Eric J. Toone Pei Zhou Drug design from the cryptic inhibitor envelope
description	The conformational dynamics of a compound has a large effect on ligand/receptor binding. Here, the authors employ NMR spectroscopy to study ligand binding to the enzyme LpxC, discovering an inhibitor envelope that was not identifiable by crystallography and subsequently developing a highly potent inhibitor.
format	article
author	Chul-Jin Lee Xiaofei Liang Qinglin Wu Javaria Najeeb Jinshi Zhao Ramesh Gopalaswamy Marie Titecat Florent Sebbane Nadine Lemaitre Eric J. Toone Pei Zhou
author_facet	Chul-Jin Lee Xiaofei Liang Qinglin Wu Javaria Najeeb Jinshi Zhao Ramesh Gopalaswamy Marie Titecat Florent Sebbane Nadine Lemaitre Eric J. Toone Pei Zhou
author_sort	Chul-Jin Lee
title	Drug design from the cryptic inhibitor envelope
title_short	Drug design from the cryptic inhibitor envelope
title_full	Drug design from the cryptic inhibitor envelope
title_fullStr	Drug design from the cryptic inhibitor envelope
title_full_unstemmed	Drug design from the cryptic inhibitor envelope
title_sort	drug design from the cryptic inhibitor envelope
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d7d0d77eb2224e92ad9e99b31e87c12f
work_keys_str_mv	AT chuljinlee drugdesignfromthecrypticinhibitorenvelope AT xiaofeiliang drugdesignfromthecrypticinhibitorenvelope AT qinglinwu drugdesignfromthecrypticinhibitorenvelope AT javarianajeeb drugdesignfromthecrypticinhibitorenvelope AT jinshizhao drugdesignfromthecrypticinhibitorenvelope AT rameshgopalaswamy drugdesignfromthecrypticinhibitorenvelope AT marietitecat drugdesignfromthecrypticinhibitorenvelope AT florentsebbane drugdesignfromthecrypticinhibitorenvelope AT nadinelemaitre drugdesignfromthecrypticinhibitorenvelope AT ericjtoone drugdesignfromthecrypticinhibitorenvelope AT peizhou drugdesignfromthecrypticinhibitorenvelope
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Drug design from the cryptic inhibitor envelope

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