Micronucleus in oral exfoliated cells and associated factors among young adults in the far south of Brazil

There is an increasing interest in the application of micronucleus (MN) assays in the clinical setting to investing the impact of environmental, genetic, life style and socioeconomic conditions on DNA. However, the evaluation of mutagenic damage among young population had not been studied and early...

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Autores principales:	Merlyn dos Santos, Mariana dos Santos, Caroline Lopes Feijo Fernandes, Edariane Menestrino Garcia Garcia, Samuel de Carvalho Dumith, Flavio Manoel Rodrigues da Silva Júnior
Formato:	article
Lenguaje:	ES
Publicado:	Sociedad Científica del Paraguay 2021
Materias:	micronucles assay dna damage biomarker young adults Engineering (General). Civil engineering (General) TA1-2040 Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/d7d39792d6624c5e89e99dc9528da4d2
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spelling	oai:doaj.org-article:d7d39792d6624c5e89e99dc9528da4d22021-12-01T23:57:56ZMicronucleus in oral exfoliated cells and associated factors among young adults in the far south of Brazil0379-91232617-473110.32480/rscp.2021.26.2.150https://doaj.org/article/d7d39792d6624c5e89e99dc9528da4d22021-11-01T00:00:00Zhttp://sociedadcientifica.org.py/ojs/index.php/rscpy/article/view/188https://doaj.org/toc/0379-9123https://doaj.org/toc/2617-4731There is an increasing interest in the application of micronucleus (MN) assays in the clinical setting to investing the impact of environmental, genetic, life style and socioeconomic conditions on DNA. However, the evaluation of mutagenic damage among young population had not been studied and early intervention in this population can prevent several health comorbidities. Thus, the present study aimed in investigate the MN presence in young adults and its associated factors. This is a cross-sectional study, composed by 155 young adults (between 18 to < 30-year-old) of both sexes. The socioeconomic and life style data was collected through a semi-structured questionnaire. Oral exfoliated cells were collected to evaluate the frequency of MN cells. Socioeconomic conditions and life style factors were not associated with the presence of MN. Twenty percent of the participants reported some chronic noncommunicable disease and almost twelve percent reports continued use of medication, both variables present a risk factor to prevalence of MN. Although mutagenesis is a process generally more related to older individuals, this study highlights the importance of monitored DNA damage between young adults and promote healthy habits to prevent the development and worse prognosis of chronic non-transmissible diseases and the consequent use of drugs.Merlyn dos SantosMariana dos SantosCaroline Lopes Feijo FernandesEdariane Menestrino Garcia GarciaSamuel de Carvalho DumithFlavio Manoel Rodrigues da Silva JúniorSociedad Científica del Paraguay articlemicronucles assaydna damagebiomarkeryoung adultsEngineering (General). Civil engineering (General)TA1-2040Science (General)Q1-390ESRevista de la Sociedad Científica del Paraguay , Vol 26, Iss 2, Pp 150-162 (2021)
institution	DOAJ
collection	DOAJ
language	ES
topic	micronucles assay dna damage biomarker young adults Engineering (General). Civil engineering (General) TA1-2040 Science (General) Q1-390
spellingShingle	micronucles assay dna damage biomarker young adults Engineering (General). Civil engineering (General) TA1-2040 Science (General) Q1-390 Merlyn dos Santos Mariana dos Santos Caroline Lopes Feijo Fernandes Edariane Menestrino Garcia Garcia Samuel de Carvalho Dumith Flavio Manoel Rodrigues da Silva Júnior Micronucleus in oral exfoliated cells and associated factors among young adults in the far south of Brazil
description	There is an increasing interest in the application of micronucleus (MN) assays in the clinical setting to investing the impact of environmental, genetic, life style and socioeconomic conditions on DNA. However, the evaluation of mutagenic damage among young population had not been studied and early intervention in this population can prevent several health comorbidities. Thus, the present study aimed in investigate the MN presence in young adults and its associated factors. This is a cross-sectional study, composed by 155 young adults (between 18 to < 30-year-old) of both sexes. The socioeconomic and life style data was collected through a semi-structured questionnaire. Oral exfoliated cells were collected to evaluate the frequency of MN cells. Socioeconomic conditions and life style factors were not associated with the presence of MN. Twenty percent of the participants reported some chronic noncommunicable disease and almost twelve percent reports continued use of medication, both variables present a risk factor to prevalence of MN. Although mutagenesis is a process generally more related to older individuals, this study highlights the importance of monitored DNA damage between young adults and promote healthy habits to prevent the development and worse prognosis of chronic non-transmissible diseases and the consequent use of drugs.
format	article
author	Merlyn dos Santos Mariana dos Santos Caroline Lopes Feijo Fernandes Edariane Menestrino Garcia Garcia Samuel de Carvalho Dumith Flavio Manoel Rodrigues da Silva Júnior
author_facet	Merlyn dos Santos Mariana dos Santos Caroline Lopes Feijo Fernandes Edariane Menestrino Garcia Garcia Samuel de Carvalho Dumith Flavio Manoel Rodrigues da Silva Júnior
author_sort	Merlyn dos Santos
title	Micronucleus in oral exfoliated cells and associated factors among young adults in the far south of Brazil
title_short	Micronucleus in oral exfoliated cells and associated factors among young adults in the far south of Brazil
title_full	Micronucleus in oral exfoliated cells and associated factors among young adults in the far south of Brazil
title_fullStr	Micronucleus in oral exfoliated cells and associated factors among young adults in the far south of Brazil
title_full_unstemmed	Micronucleus in oral exfoliated cells and associated factors among young adults in the far south of Brazil
title_sort	micronucleus in oral exfoliated cells and associated factors among young adults in the far south of brazil
publisher	Sociedad Científica del Paraguay
publishDate	2021
url	https://doaj.org/article/d7d39792d6624c5e89e99dc9528da4d2
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Micronucleus in oral exfoliated cells and associated factors among young adults in the far south of Brazil

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