A Cdk4/6-dependent phosphorylation gradient regulates the early to late G1 phase transition

A Cdk4/6-dependent phosphorylation gradient regulates the early to late G1 phase transition

Abstract During early G1 phase, Rb is exclusively mono-phosphorylated by cyclin D:Cdk4/6, generating 14 different isoforms with specific binding patterns to E2Fs and other cellular protein targets. While mono-phosphorylated Rb is dispensable for early G1 phase progression, interfering with cyclin D:...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Manuel Kaulich, Verena M. Link, John D. Lapek, Yeon J. Lee, Christopher K. Glass, David J. Gonzalez, Steven F. Dowdy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/d7d64e91293648eb929fa5c8632d7b65
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares