The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress

Yann Quidé,1,2 Leonardo Tozzi,3 Mark Corcoran,4 Dara M Cannon,5 Maria R Dauvermann6,7 1School of Psychiatry, University of New South Wales (UNSW), Sydney, NSW, Australia; 2Neuroscience Research Australia, Randwick, NSW, Australia; 3Department of Psychiatry and Behavioral Sciences, Stanfor...

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Autores principales:	Quidé Y, Tozzi L, Corcoran M, Cannon DM, Dauvermann MR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	bipolar disorder childhood trauma vulnerability early onset peripheral blood marker brain Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d7d66fd8b7e84f9da43ccbfe7ea6de7b
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spelling	oai:doaj.org-article:d7d66fd8b7e84f9da43ccbfe7ea6de7b2021-12-02T16:11:14ZThe Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress1178-2021https://doaj.org/article/d7d66fd8b7e84f9da43ccbfe7ea6de7b2020-12-01T00:00:00Zhttps://www.dovepress.com/the-impact-of-childhood-trauma-on-developing-bipolar-disorder-current--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yann Quidé,1,2 Leonardo Tozzi,3 Mark Corcoran,4 Dara M Cannon,5 Maria R Dauvermann6,7 1School of Psychiatry, University of New South Wales (UNSW), Sydney, NSW, Australia; 2Neuroscience Research Australia, Randwick, NSW, Australia; 3Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; 4School of Psychology, National University of Ireland Galway, Galway, Ireland; 5Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, School of Medicine, National University of Ireland Galway, Galway, Ireland; 6Department of Psychiatry, University of Cambridge, Cambridge, UK; 7McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USACorrespondence: Maria R DauvermannDepartment of Psychiatry, University of Cambridge, Clifford Allbutt Building, Cambridge Biomedical Campus Box 58, Cambridge CB2 0XY, UKTel +441223 465246Email md874@medschl.cam.ac.ukAbstract: Childhood trauma (CT) has been repeatedly linked to earlier onset and greater severity of bipolar disorder (BD) in adulthood. However, such knowledge is mostly based on retrospective and cross-sectional studies in adults with BD. The first objective of this selective review is to characterize the short-term effects of CT in the development of BD by focusing on studies in young people. The second objective is to describe the longer-term consequences of CT by considering studies with adult participants. This review first outlines the most prominent hypotheses linking CT exposure and the onset of BD. Then, it summarizes the psychological and biological risk factors implicated in the development of BD, followed by a discussion of original studies that investigated the role of CT in young people with early-onset BD, youths at increased risk of developing BD, or young people with BD with a focus on subclinical and clinical outcome measures. The review considers additional biological and psychological factors associated with a negative impact of CT on the long-term course of BD in later adulthood. Finally, we discuss how the integration of information of CT can improve ongoing early identification of BD and mitigate severe clinical expression in later adulthood.Keywords: bipolar disorder, childhood trauma, vulnerability, early onset, peripheral blood marker, brainQuidé YTozzi LCorcoran MCannon DMDauvermann MRDove Medical Pressarticlebipolar disorderchildhood traumavulnerabilityearly onsetperipheral blood markerbrainNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 3095-3115 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	bipolar disorder childhood trauma vulnerability early onset peripheral blood marker brain Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	bipolar disorder childhood trauma vulnerability early onset peripheral blood marker brain Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Quidé Y Tozzi L Corcoran M Cannon DM Dauvermann MR The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress
description	Yann Quidé,1,2 Leonardo Tozzi,3 Mark Corcoran,4 Dara M Cannon,5 Maria R Dauvermann6,7 1School of Psychiatry, University of New South Wales (UNSW), Sydney, NSW, Australia; 2Neuroscience Research Australia, Randwick, NSW, Australia; 3Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; 4School of Psychology, National University of Ireland Galway, Galway, Ireland; 5Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, School of Medicine, National University of Ireland Galway, Galway, Ireland; 6Department of Psychiatry, University of Cambridge, Cambridge, UK; 7McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USACorrespondence: Maria R DauvermannDepartment of Psychiatry, University of Cambridge, Clifford Allbutt Building, Cambridge Biomedical Campus Box 58, Cambridge CB2 0XY, UKTel +441223 465246Email md874@medschl.cam.ac.ukAbstract: Childhood trauma (CT) has been repeatedly linked to earlier onset and greater severity of bipolar disorder (BD) in adulthood. However, such knowledge is mostly based on retrospective and cross-sectional studies in adults with BD. The first objective of this selective review is to characterize the short-term effects of CT in the development of BD by focusing on studies in young people. The second objective is to describe the longer-term consequences of CT by considering studies with adult participants. This review first outlines the most prominent hypotheses linking CT exposure and the onset of BD. Then, it summarizes the psychological and biological risk factors implicated in the development of BD, followed by a discussion of original studies that investigated the role of CT in young people with early-onset BD, youths at increased risk of developing BD, or young people with BD with a focus on subclinical and clinical outcome measures. The review considers additional biological and psychological factors associated with a negative impact of CT on the long-term course of BD in later adulthood. Finally, we discuss how the integration of information of CT can improve ongoing early identification of BD and mitigate severe clinical expression in later adulthood.Keywords: bipolar disorder, childhood trauma, vulnerability, early onset, peripheral blood marker, brain
format	article
author	Quidé Y Tozzi L Corcoran M Cannon DM Dauvermann MR
author_facet	Quidé Y Tozzi L Corcoran M Cannon DM Dauvermann MR
author_sort	Quidé Y
title	The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress
title_short	The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress
title_full	The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress
title_fullStr	The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress
title_full_unstemmed	The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress
title_sort	impact of childhood trauma on developing bipolar disorder: current understanding and ensuring continued progress
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d7d66fd8b7e84f9da43ccbfe7ea6de7b
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The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress

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