Mediastinal mixed germ cell tumor: A case report and literature review

Mixed germ cell tumor (MGCT) mainly occurs in young women’s ovaries and men’s testicles and rarely occurs outside the gonad. Fewer than 10 cases of mediastinal MGCT are available in PubMed, Embase, and other databases in English, while mediastinal MGCT with three pathological components, such as yol...

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Autores principales:	Hu Xianwen, Li Dandan, Xia Jinhua, Wang Pan, Cai Jiong
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	mediastinal mixed germ cell tumor computed tomography case report Medicine R
Acceso en línea:	https://doaj.org/article/d7d85b16a412467eb9faa5001497563a
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spelling	oai:doaj.org-article:d7d85b16a412467eb9faa5001497563a2021-12-05T14:10:54ZMediastinal mixed germ cell tumor: A case report and literature review2391-546310.1515/med-2021-0293https://doaj.org/article/d7d85b16a412467eb9faa5001497563a2021-06-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0293https://doaj.org/toc/2391-5463Mixed germ cell tumor (MGCT) mainly occurs in young women’s ovaries and men’s testicles and rarely occurs outside the gonad. Fewer than 10 cases of mediastinal MGCT are available in PubMed, Embase, and other databases in English, while mediastinal MGCT with three pathological components, such as yolk sac tumor, immature teratoma, and embryonal carcinoma, has not been reported previously. A 12-year-old male sought medical attention for chest discomfort and underwent a computed tomography (CT) scan. A large soft tissue mass occupying most of the left thoracic cavity and mediastinum was detected. A CT-guided biopsy was performed, and an MGCT was diagnosed with pathological components, including yolk sac tumor, immature teratoma, and a small amount of embryonal carcinoma. Due to the large size of the tumor, the patient was treated with an EP regimen (etoposide + cisplatin) and paclitaxel + ifosfamide + cisplatin interstitial chemotherapy. The patient was followed up for 6 months and was alive with the disease. To the best of our knowledge, this is the 10th patient with MGCT in the mediastinum. The incidence of mediastinal MGCT is low, but it should still be considered one of the differential diagnoses of isolated pleural fibroma and neurogenic tumors.Hu XianwenLi DandanXia JinhuaWang PanCai JiongDe Gruyterarticlemediastinalmixed germ cell tumorcomputed tomographycase reportMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 892-898 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mediastinal mixed germ cell tumor computed tomography case report Medicine R
spellingShingle	mediastinal mixed germ cell tumor computed tomography case report Medicine R Hu Xianwen Li Dandan Xia Jinhua Wang Pan Cai Jiong Mediastinal mixed germ cell tumor: A case report and literature review
description	Mixed germ cell tumor (MGCT) mainly occurs in young women’s ovaries and men’s testicles and rarely occurs outside the gonad. Fewer than 10 cases of mediastinal MGCT are available in PubMed, Embase, and other databases in English, while mediastinal MGCT with three pathological components, such as yolk sac tumor, immature teratoma, and embryonal carcinoma, has not been reported previously. A 12-year-old male sought medical attention for chest discomfort and underwent a computed tomography (CT) scan. A large soft tissue mass occupying most of the left thoracic cavity and mediastinum was detected. A CT-guided biopsy was performed, and an MGCT was diagnosed with pathological components, including yolk sac tumor, immature teratoma, and a small amount of embryonal carcinoma. Due to the large size of the tumor, the patient was treated with an EP regimen (etoposide + cisplatin) and paclitaxel + ifosfamide + cisplatin interstitial chemotherapy. The patient was followed up for 6 months and was alive with the disease. To the best of our knowledge, this is the 10th patient with MGCT in the mediastinum. The incidence of mediastinal MGCT is low, but it should still be considered one of the differential diagnoses of isolated pleural fibroma and neurogenic tumors.
format	article
author	Hu Xianwen Li Dandan Xia Jinhua Wang Pan Cai Jiong
author_facet	Hu Xianwen Li Dandan Xia Jinhua Wang Pan Cai Jiong
author_sort	Hu Xianwen
title	Mediastinal mixed germ cell tumor: A case report and literature review
title_short	Mediastinal mixed germ cell tumor: A case report and literature review
title_full	Mediastinal mixed germ cell tumor: A case report and literature review
title_fullStr	Mediastinal mixed germ cell tumor: A case report and literature review
title_full_unstemmed	Mediastinal mixed germ cell tumor: A case report and literature review
title_sort	mediastinal mixed germ cell tumor: a case report and literature review
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/d7d85b16a412467eb9faa5001497563a
work_keys_str_mv	AT huxianwen mediastinalmixedgermcelltumoracasereportandliteraturereview AT lidandan mediastinalmixedgermcelltumoracasereportandliteraturereview AT xiajinhua mediastinalmixedgermcelltumoracasereportandliteraturereview AT wangpan mediastinalmixedgermcelltumoracasereportandliteraturereview AT caijiong mediastinalmixedgermcelltumoracasereportandliteraturereview
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Mediastinal mixed germ cell tumor: A case report and literature review

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